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No increased cardiovascular mortality among early rheumatoid arthritis patients: a nationwide register study in 2000-2008.
Clin Exp Rheumatol. 2015 May-Jun; 33(3):391-8.CE

Abstract

OBJECTIVES

To assess cardiovascular (CV) mortality in early rheumatoid arthritis (RA), and the impact of RA medications on CV mortality.

METHODS

We identified all incident RA patients over 18 years of age diagnosed between 2000 and 2007 in Finland. Causes of death were analysed until the end of the year 2008. We used competing-risks regression models to assess the impact of different variables such as RA medications on CV mortality. CV mortality was compared with that of the age- and sex-specific general population.

RESULTS

We identified 14,878 incident RA patients (68% women, 63% rheumatoid factor (RF) positive, mean age 55.8/57.5 years in men/women), of whom more than 80% received RA medications for longer than 90% of their individual patient-years. By the end of 2008, 1,157 patients died, 501 (43%) of whom of CV causes. The standardised mortality ratio (SMR) for CV deaths in the entire RA cohort was 0.57 (95% CI 0.52 to 0.62). Along with traditional CV risk factors, the presence of RF and the use of glucocorticoids was associated with a higher risk of CV death, whereas the use of methotrexate was associated with a lower risk.

CONCLUSIONS

These nationwide results suggest that patients with recent-onset RA who receive consistent RA medication have no increased risk for CV mortality compared to the general population, at least in the early years of the disease. The use of methotrexate is associated with lower CV mortality, whereas the use of glucocorticoids is associated with a higher than average CV mortality.

Authors+Show Affiliations

Medical School, University of Helsinki, Helsinki, Finland.Department of Internal Medicine, University of Helsinki and Helsinki University Central Hospital; and Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.Research Department, the Social Insurance Institution, Turku, Finland.Unit of Primary Health Care, Helsinki University Central Hospital; and Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland.Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland.ORTON Rehabilitation Centre, ORTON Foundation, Helsinki, Finland.Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti; and School of Medicine, Tampere University, Tampere, Finland.Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25936374

Citation

Kerola, Anne M., et al. "No Increased Cardiovascular Mortality Among Early Rheumatoid Arthritis Patients: a Nationwide Register Study in 2000-2008." Clinical and Experimental Rheumatology, vol. 33, no. 3, 2015, pp. 391-8.
Kerola AM, Nieminen TV, Virta LJ, et al. No increased cardiovascular mortality among early rheumatoid arthritis patients: a nationwide register study in 2000-2008. Clin Exp Rheumatol. 2015;33(3):391-8.
Kerola, A. M., Nieminen, T. V., Virta, L. J., Kautiainen, H., Kerola, T., Pohjolainen, T., Kauppi, M. J., & Puolakka, K. (2015). No increased cardiovascular mortality among early rheumatoid arthritis patients: a nationwide register study in 2000-2008. Clinical and Experimental Rheumatology, 33(3), 391-8.
Kerola AM, et al. No Increased Cardiovascular Mortality Among Early Rheumatoid Arthritis Patients: a Nationwide Register Study in 2000-2008. Clin Exp Rheumatol. 2015 May-Jun;33(3):391-8. PubMed PMID: 25936374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No increased cardiovascular mortality among early rheumatoid arthritis patients: a nationwide register study in 2000-2008. AU - Kerola,Anne M, AU - Nieminen,Tuomo V M, AU - Virta,Lauri J, AU - Kautiainen,Hannu, AU - Kerola,Tuomas, AU - Pohjolainen,Timo, AU - Kauppi,Markku J, AU - Puolakka,Kari, Y1 - 2015/05/01/ PY - 2014/10/21/received PY - 2015/01/22/accepted PY - 2015/5/5/entrez PY - 2015/5/6/pubmed PY - 2015/8/19/medline SP - 391 EP - 8 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 33 IS - 3 N2 - OBJECTIVES: To assess cardiovascular (CV) mortality in early rheumatoid arthritis (RA), and the impact of RA medications on CV mortality. METHODS: We identified all incident RA patients over 18 years of age diagnosed between 2000 and 2007 in Finland. Causes of death were analysed until the end of the year 2008. We used competing-risks regression models to assess the impact of different variables such as RA medications on CV mortality. CV mortality was compared with that of the age- and sex-specific general population. RESULTS: We identified 14,878 incident RA patients (68% women, 63% rheumatoid factor (RF) positive, mean age 55.8/57.5 years in men/women), of whom more than 80% received RA medications for longer than 90% of their individual patient-years. By the end of 2008, 1,157 patients died, 501 (43%) of whom of CV causes. The standardised mortality ratio (SMR) for CV deaths in the entire RA cohort was 0.57 (95% CI 0.52 to 0.62). Along with traditional CV risk factors, the presence of RF and the use of glucocorticoids was associated with a higher risk of CV death, whereas the use of methotrexate was associated with a lower risk. CONCLUSIONS: These nationwide results suggest that patients with recent-onset RA who receive consistent RA medication have no increased risk for CV mortality compared to the general population, at least in the early years of the disease. The use of methotrexate is associated with lower CV mortality, whereas the use of glucocorticoids is associated with a higher than average CV mortality. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/25936374/No_increased_cardiovascular_mortality_among_early_rheumatoid_arthritis_patients:_a_nationwide_register_study_in_2000_2008_ L2 - http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=25936374 DB - PRIME DP - Unbound Medicine ER -