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Diagnostic ability of macular ganglion cell asymmetry for glaucoma.
Clin Exp Ophthalmol. 2015 Nov; 43(8):720-6.CE

Abstract

BACKGROUND

Using spectral-domain optical coherence tomography (OCT), this study aims to investigate the glaucoma diagnostic ability of macular ganglion cell asymmetry analysis.

DESIGN

A cross-sectional study was conducted. This study was performed to investigate glaucoma diagnostic ability of macular ganglion cell asymmetry analysis in eyes with various degrees of glaucoma.

PARTICIPANTS

We enrolled 181 healthy eyes and 265 glaucomatous eyes.

METHODS

Glaucomatous eyes were subdivided into pre-perimetric, early, moderate and advanced-to-severe glaucoma based on visual field test results. For each eye, macular ganglion cell-inner plexiform layer (GCIPL) thickness was measured using OCT. Average GCIPL thickness, GCIPL thicknesses in superior and inferior hemispheres, absolute difference in GCIPL thickness between superior and inferior hemispheres and GCIPL asymmetry index calculated as the absolute value of log10 (inferior hemisphere thickness/superior hemisphere thickness) were analysed.

MAIN OUTCOME MEASURES

Areas under the receiver operating characteristics curves (AUCs) of GCIPL parameter were calculated and compared.

RESULTS

All of the GCIPL parameters showed good glaucoma diagnostic ability (AUCs ≥ 0.817, P < 0.01). AUCs of average, superior and inferior GCIPL thickness increased as the severity of glaucoma increased. GCIPL thickness difference and asymmetry index showed the highest AUCs in early and moderate glaucoma and lower AUCs in pre-perimetric and advanced-to-severe glaucoma. GCIPL thickness difference and asymmetry index showed better glaucoma diagnostic ability than other GCIPL parameters only in early stage of glaucoma (P < 0.05); in other stages, these parameters had similar to or worse glaucoma diagnostic ability than other GCIPL parameters.

CONCLUSIONS

Macular ganglion cell asymmetry analysis showed good glaucoma diagnostic ability, especially in early-stage glaucoma. However, it has limited usefulness in other stages of glaucoma.

Authors+Show Affiliations

Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea.Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea.Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25939316

Citation

Hwang, Young Hoon, et al. "Diagnostic Ability of Macular Ganglion Cell Asymmetry for Glaucoma." Clinical & Experimental Ophthalmology, vol. 43, no. 8, 2015, pp. 720-6.
Hwang YH, Ahn SI, Ko SJ. Diagnostic ability of macular ganglion cell asymmetry for glaucoma. Clin Experiment Ophthalmol. 2015;43(8):720-6.
Hwang, Y. H., Ahn, S. I., & Ko, S. J. (2015). Diagnostic ability of macular ganglion cell asymmetry for glaucoma. Clinical & Experimental Ophthalmology, 43(8), 720-6. https://doi.org/10.1111/ceo.12545
Hwang YH, Ahn SI, Ko SJ. Diagnostic Ability of Macular Ganglion Cell Asymmetry for Glaucoma. Clin Experiment Ophthalmol. 2015;43(8):720-6. PubMed PMID: 25939316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic ability of macular ganglion cell asymmetry for glaucoma. AU - Hwang,Young Hoon, AU - Ahn,Sang Il, AU - Ko,Sung Ju, Y1 - 2015/07/01/ PY - 2015/01/31/received PY - 2015/04/22/accepted PY - 2015/5/6/entrez PY - 2015/5/6/pubmed PY - 2016/5/25/medline KW - ganglion cell KW - glaucoma KW - macula KW - optical coherence tomography SP - 720 EP - 6 JF - Clinical & experimental ophthalmology JO - Clin. Experiment. Ophthalmol. VL - 43 IS - 8 N2 - BACKGROUND: Using spectral-domain optical coherence tomography (OCT), this study aims to investigate the glaucoma diagnostic ability of macular ganglion cell asymmetry analysis. DESIGN: A cross-sectional study was conducted. This study was performed to investigate glaucoma diagnostic ability of macular ganglion cell asymmetry analysis in eyes with various degrees of glaucoma. PARTICIPANTS: We enrolled 181 healthy eyes and 265 glaucomatous eyes. METHODS: Glaucomatous eyes were subdivided into pre-perimetric, early, moderate and advanced-to-severe glaucoma based on visual field test results. For each eye, macular ganglion cell-inner plexiform layer (GCIPL) thickness was measured using OCT. Average GCIPL thickness, GCIPL thicknesses in superior and inferior hemispheres, absolute difference in GCIPL thickness between superior and inferior hemispheres and GCIPL asymmetry index calculated as the absolute value of log10 (inferior hemisphere thickness/superior hemisphere thickness) were analysed. MAIN OUTCOME MEASURES: Areas under the receiver operating characteristics curves (AUCs) of GCIPL parameter were calculated and compared. RESULTS: All of the GCIPL parameters showed good glaucoma diagnostic ability (AUCs ≥ 0.817, P < 0.01). AUCs of average, superior and inferior GCIPL thickness increased as the severity of glaucoma increased. GCIPL thickness difference and asymmetry index showed the highest AUCs in early and moderate glaucoma and lower AUCs in pre-perimetric and advanced-to-severe glaucoma. GCIPL thickness difference and asymmetry index showed better glaucoma diagnostic ability than other GCIPL parameters only in early stage of glaucoma (P < 0.05); in other stages, these parameters had similar to or worse glaucoma diagnostic ability than other GCIPL parameters. CONCLUSIONS: Macular ganglion cell asymmetry analysis showed good glaucoma diagnostic ability, especially in early-stage glaucoma. However, it has limited usefulness in other stages of glaucoma. SN - 1442-9071 UR - https://www.unboundmedicine.com/medline/citation/25939316/Diagnostic_ability_of_macular_ganglion_cell_asymmetry_for_glaucoma_ L2 - https://doi.org/10.1111/ceo.12545 DB - PRIME DP - Unbound Medicine ER -