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Groundwater pesticide levels and the association with Parkinson disease.
Int J Toxicol. 2015 May-Jun; 34(3):266-73.IJ

Abstract

It is unclear whether exposure to environmentally relevant levels of pesticides in groundwater is associated with an increased risk of Parkinson disease (PD). The purpose of this study was to examine the relationship between PD and pesticide levels in groundwater. This cross-sectional study included 332 971 Medicare beneficiaries, including 4207 prevalent cases of PD from the 2007 Colorado Medicare Beneficiary Database. Residential pesticide levels were estimated from a spatial model based on 286 well water samples with atrazine, simazine, alachlor, and metolachlor measurements. A logistic regression model with known PD risk factors was used to assess the association between residential groundwater pesticide levels and prevalent PD. We found that for every 1.0 µg/L of pesticide in groundwater, the risk of PD increases by 3% (odds ratio = 1.03; 95% confidence interval: 1.02-1.04) while adjusting for age, race/ethnicity, and gender suggesting that higher age-standardized PD prevalence ratios are associated with increasing levels of pesticides in groundwater.

Authors+Show Affiliations

Department of Family Medicine, University of Colorado, Denver, CO, USA kathy.james@ucdenver.edu.Department of Neurological Sciences, Rush University, Chicago, IL, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25939349

Citation

James, Katherine A., and Deborah A. Hall. "Groundwater Pesticide Levels and the Association With Parkinson Disease." International Journal of Toxicology, vol. 34, no. 3, 2015, pp. 266-73.
James KA, Hall DA. Groundwater pesticide levels and the association with Parkinson disease. Int J Toxicol. 2015;34(3):266-73.
James, K. A., & Hall, D. A. (2015). Groundwater pesticide levels and the association with Parkinson disease. International Journal of Toxicology, 34(3), 266-73. https://doi.org/10.1177/1091581815583561
James KA, Hall DA. Groundwater Pesticide Levels and the Association With Parkinson Disease. Int J Toxicol. 2015 May-Jun;34(3):266-73. PubMed PMID: 25939349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Groundwater pesticide levels and the association with Parkinson disease. AU - James,Katherine A, AU - Hall,Deborah A, Y1 - 2015/05/04/ PY - 2015/5/6/entrez PY - 2015/5/6/pubmed PY - 2016/3/2/medline KW - Geographic Information Systems KW - Medicare KW - Parkinson disease KW - atrazine KW - pesticides SP - 266 EP - 73 JF - International journal of toxicology JO - Int J Toxicol VL - 34 IS - 3 N2 - It is unclear whether exposure to environmentally relevant levels of pesticides in groundwater is associated with an increased risk of Parkinson disease (PD). The purpose of this study was to examine the relationship between PD and pesticide levels in groundwater. This cross-sectional study included 332 971 Medicare beneficiaries, including 4207 prevalent cases of PD from the 2007 Colorado Medicare Beneficiary Database. Residential pesticide levels were estimated from a spatial model based on 286 well water samples with atrazine, simazine, alachlor, and metolachlor measurements. A logistic regression model with known PD risk factors was used to assess the association between residential groundwater pesticide levels and prevalent PD. We found that for every 1.0 µg/L of pesticide in groundwater, the risk of PD increases by 3% (odds ratio = 1.03; 95% confidence interval: 1.02-1.04) while adjusting for age, race/ethnicity, and gender suggesting that higher age-standardized PD prevalence ratios are associated with increasing levels of pesticides in groundwater. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/25939349/Groundwater_pesticide_levels_and_the_association_with_Parkinson_disease_ L2 - https://journals.sagepub.com/doi/10.1177/1091581815583561?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -