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The Second to Fourth Digit Ratio in Acne Vulgaris.
Pediatr Dermatol 2015 Sep-Oct; 32(5):651-5PD

Abstract

BACKGROUND

Androgen hormones are thought to play a leading role in acne vulgaris (AV). The 2D:4D digit ratio refers to the ratio of the length of the second finger (index finger) to that of the fourth finger (ring finger). It is thought that the balance between fetal testosterone and fetal estrogen during the prenatal period largely determines this ratio, which does not change with age in the postnatal period.

METHODS

Patients with no other disease except AV and a control group of healthy patients were included in the study. Sex, age, family history, age of onset, and duration of disease in patients diagnosed with AV were recorded. The lengths of the patients' second and fourth fingers were measured using a digital caliper with a resolution of 0.01 mm. Hormone levels were also measured.

RESULTS

When the 2D:4D ratio for the right hand and the left hand (separately) as well as the average (mean) 2D:4D ratio of both hands in male and female patients were compared with those of the control group, no statistically significant difference was observed. The right 2D:4D ratio of female patients was positively correlated with free androgen index percentage and prolactin values and negatively correlated with sex hormone-binding globulin. The left 2D:4D ratio of female patients was found to be positively correlated with disease duration and follicle-stimulating hormone values.

CONCLUSION

The 2D:4D ratio was not significantly different between the group with AV and the control group independent of sex. Also, we did not observe a significant association with age of onset, severity of disease, or family history.

Authors+Show Affiliations

Department of Dermatology and Venereology, Konya Numune Hospital, Konya, Turkey.Department of Family Medicine, Konya Education and Training Hospital, Konya, Turkey.Department of Dermatology and Venereology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.Department of Dermatology and Venereology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.Department of Public Health, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25940068

Citation

Unal, Mehmet, et al. "The Second to Fourth Digit Ratio in Acne Vulgaris." Pediatric Dermatology, vol. 32, no. 5, 2015, pp. 651-5.
Unal M, Urun Unal G, Balevi S, et al. The Second to Fourth Digit Ratio in Acne Vulgaris. Pediatr Dermatol. 2015;32(5):651-5.
Unal, M., Urun Unal, G., Balevi, S., Tol, H., & Uyar, M. (2015). The Second to Fourth Digit Ratio in Acne Vulgaris. Pediatric Dermatology, 32(5), pp. 651-5. doi:10.1111/pde.12594.
Unal M, et al. The Second to Fourth Digit Ratio in Acne Vulgaris. Pediatr Dermatol. 2015;32(5):651-5. PubMed PMID: 25940068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Second to Fourth Digit Ratio in Acne Vulgaris. AU - Unal,Mehmet, AU - Urun Unal,Gulbahar, AU - Balevi,Sukru, AU - Tol,Hüseyin, AU - Uyar,Mehmet, Y1 - 2015/05/04/ PY - 2015/5/6/entrez PY - 2015/5/6/pubmed PY - 2016/7/1/medline SP - 651 EP - 5 JF - Pediatric dermatology JO - Pediatr Dermatol VL - 32 IS - 5 N2 - BACKGROUND: Androgen hormones are thought to play a leading role in acne vulgaris (AV). The 2D:4D digit ratio refers to the ratio of the length of the second finger (index finger) to that of the fourth finger (ring finger). It is thought that the balance between fetal testosterone and fetal estrogen during the prenatal period largely determines this ratio, which does not change with age in the postnatal period. METHODS: Patients with no other disease except AV and a control group of healthy patients were included in the study. Sex, age, family history, age of onset, and duration of disease in patients diagnosed with AV were recorded. The lengths of the patients' second and fourth fingers were measured using a digital caliper with a resolution of 0.01 mm. Hormone levels were also measured. RESULTS: When the 2D:4D ratio for the right hand and the left hand (separately) as well as the average (mean) 2D:4D ratio of both hands in male and female patients were compared with those of the control group, no statistically significant difference was observed. The right 2D:4D ratio of female patients was positively correlated with free androgen index percentage and prolactin values and negatively correlated with sex hormone-binding globulin. The left 2D:4D ratio of female patients was found to be positively correlated with disease duration and follicle-stimulating hormone values. CONCLUSION: The 2D:4D ratio was not significantly different between the group with AV and the control group independent of sex. Also, we did not observe a significant association with age of onset, severity of disease, or family history. SN - 1525-1470 UR - https://www.unboundmedicine.com/medline/citation/25940068/The_Second_to_Fourth_Digit_Ratio_in_Acne_Vulgaris_ L2 - https://doi.org/10.1111/pde.12594 DB - PRIME DP - Unbound Medicine ER -