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Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity.

Abstract

AIMS/HYPOTHESIS

The incidence of type 1 diabetes in children is increasing in Sweden, as is the prevalence of maternal overweight/obesity. Therefore, the aim of this study was to investigate if maternal overweight/obesity increases the risk of type 1 diabetes in offspring of parents with and without diabetes, and of different ethnicities.

METHODS

The study cohort comprised 1,263,358 children, born in Sweden between 1992 and 2004. Children were followed from birth until diagnosis of type 1 diabetes, emigration, death or end of follow-up in 2009, whichever occurred first. First trimester maternal BMI was calculated (kg/m(2)). Poisson regression was used to calculate incidence rate ratios (IRRs) with 95% CI for type 1 diabetes in the offspring.

RESULTS

The risk of type 1 diabetes was increased in offspring of parents with any type of diabetes regardless of parental ethnicity. High first trimester maternal BMI was associated with increased risk of type 1 diabetes only in offspring of parents without diabetes (IRR 1.33 [95% CI 1.20, 1.48]).

CONCLUSIONS/INTERPRETATION

Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Environmental Medicine, Division of Epidemiology, Unit of Cardiovascular Epidemiology, Karolinska Institutet, Nobels väg 13, Box 210, SE-171 77, Stockholm, Sweden.

    ,

    Source

    Diabetologia 58:7 2015 Jul pg 1464-73

    MeSH

    Adolescent
    Adult
    Body Mass Index
    Child
    Child, Preschool
    Cohort Studies
    Databases, Factual
    Diabetes Mellitus, Type 1
    Ethnic Groups
    Fathers
    Female
    Humans
    Incidence
    Infant
    Infant, Newborn
    Male
    Maternal Age
    Mothers
    Obesity
    Overweight
    Pregnancy
    Pregnancy Complications
    Risk Factors
    Smoking
    Socioeconomic Factors
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25940642

    Citation

    Hussen, Hozan I., et al. "Maternal Overweight and Obesity Are Associated With Increased Risk of Type 1 Diabetes in Offspring of Parents Without Diabetes Regardless of Ethnicity." Diabetologia, vol. 58, no. 7, 2015, pp. 1464-73.
    Hussen HI, Persson M, Moradi T. Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity. Diabetologia. 2015;58(7):1464-73.
    Hussen, H. I., Persson, M., & Moradi, T. (2015). Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity. Diabetologia, 58(7), pp. 1464-73. doi:10.1007/s00125-015-3580-1.
    Hussen HI, Persson M, Moradi T. Maternal Overweight and Obesity Are Associated With Increased Risk of Type 1 Diabetes in Offspring of Parents Without Diabetes Regardless of Ethnicity. Diabetologia. 2015;58(7):1464-73. PubMed PMID: 25940642.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity. AU - Hussen,Hozan I, AU - Persson,Martina, AU - Moradi,Tahereh, Y1 - 2015/05/06/ PY - 2014/12/09/received PY - 2015/03/16/accepted PY - 2015/5/6/entrez PY - 2015/5/6/pubmed PY - 2016/3/11/medline SP - 1464 EP - 73 JF - Diabetologia JO - Diabetologia VL - 58 IS - 7 N2 - AIMS/HYPOTHESIS: The incidence of type 1 diabetes in children is increasing in Sweden, as is the prevalence of maternal overweight/obesity. Therefore, the aim of this study was to investigate if maternal overweight/obesity increases the risk of type 1 diabetes in offspring of parents with and without diabetes, and of different ethnicities. METHODS: The study cohort comprised 1,263,358 children, born in Sweden between 1992 and 2004. Children were followed from birth until diagnosis of type 1 diabetes, emigration, death or end of follow-up in 2009, whichever occurred first. First trimester maternal BMI was calculated (kg/m(2)). Poisson regression was used to calculate incidence rate ratios (IRRs) with 95% CI for type 1 diabetes in the offspring. RESULTS: The risk of type 1 diabetes was increased in offspring of parents with any type of diabetes regardless of parental ethnicity. High first trimester maternal BMI was associated with increased risk of type 1 diabetes only in offspring of parents without diabetes (IRR 1.33 [95% CI 1.20, 1.48]). CONCLUSIONS/INTERPRETATION: Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/25940642/full_citation L2 - https://dx.doi.org/10.1007/s00125-015-3580-1 DB - PRIME DP - Unbound Medicine ER -