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Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity.
Diabetologia 2015; 58(7):1464-73D

Abstract

AIMS/HYPOTHESIS

The incidence of type 1 diabetes in children is increasing in Sweden, as is the prevalence of maternal overweight/obesity. Therefore, the aim of this study was to investigate if maternal overweight/obesity increases the risk of type 1 diabetes in offspring of parents with and without diabetes, and of different ethnicities.

METHODS

The study cohort comprised 1,263,358 children, born in Sweden between 1992 and 2004. Children were followed from birth until diagnosis of type 1 diabetes, emigration, death or end of follow-up in 2009, whichever occurred first. First trimester maternal BMI was calculated (kg/m(2)). Poisson regression was used to calculate incidence rate ratios (IRRs) with 95% CI for type 1 diabetes in the offspring.

RESULTS

The risk of type 1 diabetes was increased in offspring of parents with any type of diabetes regardless of parental ethnicity. High first trimester maternal BMI was associated with increased risk of type 1 diabetes only in offspring of parents without diabetes (IRR 1.33 [95% CI 1.20, 1.48]).

CONCLUSIONS/INTERPRETATION

Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity.

Authors+Show Affiliations

Department of Environmental Medicine, Division of Epidemiology, Unit of Cardiovascular Epidemiology, Karolinska Institutet, Nobels väg 13, Box 210, SE-171 77, Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25940642

Citation

Hussen, Hozan I., et al. "Maternal Overweight and Obesity Are Associated With Increased Risk of Type 1 Diabetes in Offspring of Parents Without Diabetes Regardless of Ethnicity." Diabetologia, vol. 58, no. 7, 2015, pp. 1464-73.
Hussen HI, Persson M, Moradi T. Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity. Diabetologia. 2015;58(7):1464-73.
Hussen, H. I., Persson, M., & Moradi, T. (2015). Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity. Diabetologia, 58(7), pp. 1464-73. doi:10.1007/s00125-015-3580-1.
Hussen HI, Persson M, Moradi T. Maternal Overweight and Obesity Are Associated With Increased Risk of Type 1 Diabetes in Offspring of Parents Without Diabetes Regardless of Ethnicity. Diabetologia. 2015;58(7):1464-73. PubMed PMID: 25940642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity. AU - Hussen,Hozan I, AU - Persson,Martina, AU - Moradi,Tahereh, Y1 - 2015/05/06/ PY - 2014/12/09/received PY - 2015/03/16/accepted PY - 2015/5/6/entrez PY - 2015/5/6/pubmed PY - 2016/3/11/medline SP - 1464 EP - 73 JF - Diabetologia JO - Diabetologia VL - 58 IS - 7 N2 - AIMS/HYPOTHESIS: The incidence of type 1 diabetes in children is increasing in Sweden, as is the prevalence of maternal overweight/obesity. Therefore, the aim of this study was to investigate if maternal overweight/obesity increases the risk of type 1 diabetes in offspring of parents with and without diabetes, and of different ethnicities. METHODS: The study cohort comprised 1,263,358 children, born in Sweden between 1992 and 2004. Children were followed from birth until diagnosis of type 1 diabetes, emigration, death or end of follow-up in 2009, whichever occurred first. First trimester maternal BMI was calculated (kg/m(2)). Poisson regression was used to calculate incidence rate ratios (IRRs) with 95% CI for type 1 diabetes in the offspring. RESULTS: The risk of type 1 diabetes was increased in offspring of parents with any type of diabetes regardless of parental ethnicity. High first trimester maternal BMI was associated with increased risk of type 1 diabetes only in offspring of parents without diabetes (IRR 1.33 [95% CI 1.20, 1.48]). CONCLUSIONS/INTERPRETATION: Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/25940642/full_citation L2 - https://dx.doi.org/10.1007/s00125-015-3580-1 DB - PRIME DP - Unbound Medicine ER -