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Nut consumption and risk of colorectal cancer in women.
Eur J Clin Nutr 2016; 70(3):333-7EJ

Abstract

BACKGROUND/OBJECTIVES

Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, the risk factors for colorectal cancer. However, the association between nut consumption and colorectal cancer risk is unclear. We aimed to examine the association of long-term nut consumption with risk of colorectal cancer.

SUBJECTS/METHODS

We prospectively followed 75,680 women who were free of cancer at baseline in the Nurses' Health Study, and examined the association between nut consumption and colorectal cancer risk. Nut consumption was assessed at baseline and updated every 2-4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models.

RESULTS

During 2,103,037 person-years of follow-up, we identified 1503 colorectal cancer cases. After adjustment for other known or suspected risk factors, women who consumed nuts 2 or more times per week (that is, ⩾ 56 g per week) had a 13% lower risk of colorectal cancer compared with those who rarely consumed nuts, but the association was not statistically significant (RR: 0.87; 95% CI: 0.72-1.05; P-trend: 0.06). No association was observed for peanut butter.

CONCLUSIONS

In this large prospective cohort of women, frequent nut consumption was not significantly associated with colorectal cancer risk after adjusting for other risk factors.

Authors+Show Affiliations

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25944181

Citation

Yang, M, et al. "Nut Consumption and Risk of Colorectal Cancer in Women." European Journal of Clinical Nutrition, vol. 70, no. 3, 2016, pp. 333-7.
Yang M, Hu FB, Giovannucci EL, et al. Nut consumption and risk of colorectal cancer in women. Eur J Clin Nutr. 2016;70(3):333-7.
Yang, M., Hu, F. B., Giovannucci, E. L., Stampfer, M. J., Willett, W. C., Fuchs, C. S., ... Bao, Y. (2016). Nut consumption and risk of colorectal cancer in women. European Journal of Clinical Nutrition, 70(3), pp. 333-7. doi:10.1038/ejcn.2015.66.
Yang M, et al. Nut Consumption and Risk of Colorectal Cancer in Women. Eur J Clin Nutr. 2016;70(3):333-7. PubMed PMID: 25944181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nut consumption and risk of colorectal cancer in women. AU - Yang,M, AU - Hu,F B, AU - Giovannucci,E L, AU - Stampfer,M J, AU - Willett,W C, AU - Fuchs,C S, AU - Wu,K, AU - Bao,Y, Y1 - 2015/05/06/ PY - 2014/09/02/received PY - 2015/02/18/revised PY - 2015/03/17/accepted PY - 2017/03/01/pmc-release PY - 2015/5/7/entrez PY - 2015/5/7/pubmed PY - 2016/12/23/medline SP - 333 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 70 IS - 3 N2 - BACKGROUND/OBJECTIVES: Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, the risk factors for colorectal cancer. However, the association between nut consumption and colorectal cancer risk is unclear. We aimed to examine the association of long-term nut consumption with risk of colorectal cancer. SUBJECTS/METHODS: We prospectively followed 75,680 women who were free of cancer at baseline in the Nurses' Health Study, and examined the association between nut consumption and colorectal cancer risk. Nut consumption was assessed at baseline and updated every 2-4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models. RESULTS: During 2,103,037 person-years of follow-up, we identified 1503 colorectal cancer cases. After adjustment for other known or suspected risk factors, women who consumed nuts 2 or more times per week (that is, ⩾ 56 g per week) had a 13% lower risk of colorectal cancer compared with those who rarely consumed nuts, but the association was not statistically significant (RR: 0.87; 95% CI: 0.72-1.05; P-trend: 0.06). No association was observed for peanut butter. CONCLUSIONS: In this large prospective cohort of women, frequent nut consumption was not significantly associated with colorectal cancer risk after adjusting for other risk factors. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/25944181/Nut_consumption_and_risk_of_colorectal_cancer_in_women_ L2 - http://dx.doi.org/10.1038/ejcn.2015.66 DB - PRIME DP - Unbound Medicine ER -