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Evaluation of Candida Colonization and Specific Humoral Responses against Candida albicans in Patients with Atopic Dermatitis.
Biomed Res Int. 2015; 2015:849206.BR

Abstract

The aim of this study was to assess the candidal colonization and specific humoral responses against Candida albicans in patients with atopic dermatitis. One hundred patients with atopic dermatitis and 50 healthy individuals were enrolled in the study. Skin and oral specimens from all participants were cultured on CHROMagar Candida medium. Isolated yeasts were identified by using the sequence of the D1/D2 domain of the 26S rRNA gene. ELISA was used for detection of IgM, IgA, and IgG antibodies against C. albicans in sera of participants. Candida species were isolated from the skin and oral cavity of 31% of the patients and 12% of the controls. There was no significant difference between Candida colonization in patients and controls (P > 0.05). Candida albicans was isolated from the skin and oral cavity of 23% of the patients and 6% of the controls (P < 0.05). There were no significant differences between serum levels of IgM and IgA in patients and controls (P > 0.05). Serum level of IgG was significantly lower in patients than in controls (P < 0.05). Type of Candida colonization can change in patients with atopic dermatitis. In addition, these patients have abnormalities in the production of antibodies against Candida albicans that may have a role in the pathogenesis of atopic dermatitis.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Medical Mycology and Parasitology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran ; Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ; Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Dermatology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Statistics, School of Health, Mazandaran University of Medical Science, Sari, Iran.Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ; Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25945349

Citation

Javad, Ghaffari, et al. "Evaluation of Candida Colonization and Specific Humoral Responses Against Candida Albicans in Patients With Atopic Dermatitis." BioMed Research International, vol. 2015, 2015, p. 849206.
Javad G, Taheri Sarvtin M, Hedayati MT, et al. Evaluation of Candida Colonization and Specific Humoral Responses against Candida albicans in Patients with Atopic Dermatitis. Biomed Res Int. 2015;2015:849206.
Javad, G., Taheri Sarvtin, M., Hedayati, M. T., Hajheydari, Z., Yazdani, J., & Shokohi, T. (2015). Evaluation of Candida Colonization and Specific Humoral Responses against Candida albicans in Patients with Atopic Dermatitis. BioMed Research International, 2015, 849206. https://doi.org/10.1155/2015/849206
Javad G, et al. Evaluation of Candida Colonization and Specific Humoral Responses Against Candida Albicans in Patients With Atopic Dermatitis. Biomed Res Int. 2015;2015:849206. PubMed PMID: 25945349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of Candida Colonization and Specific Humoral Responses against Candida albicans in Patients with Atopic Dermatitis. AU - Javad,Ghaffari, AU - Taheri Sarvtin,Mehdi, AU - Hedayati,Mohammad Taghi, AU - Hajheydari,Zohreh, AU - Yazdani,Jamshid, AU - Shokohi,Tahereh, Y1 - 2015/04/06/ PY - 2014/12/01/received PY - 2015/03/16/revised PY - 2015/03/17/accepted PY - 2015/5/7/entrez PY - 2015/5/7/pubmed PY - 2016/1/26/medline SP - 849206 EP - 849206 JF - BioMed research international JO - Biomed Res Int VL - 2015 N2 - The aim of this study was to assess the candidal colonization and specific humoral responses against Candida albicans in patients with atopic dermatitis. One hundred patients with atopic dermatitis and 50 healthy individuals were enrolled in the study. Skin and oral specimens from all participants were cultured on CHROMagar Candida medium. Isolated yeasts were identified by using the sequence of the D1/D2 domain of the 26S rRNA gene. ELISA was used for detection of IgM, IgA, and IgG antibodies against C. albicans in sera of participants. Candida species were isolated from the skin and oral cavity of 31% of the patients and 12% of the controls. There was no significant difference between Candida colonization in patients and controls (P > 0.05). Candida albicans was isolated from the skin and oral cavity of 23% of the patients and 6% of the controls (P < 0.05). There were no significant differences between serum levels of IgM and IgA in patients and controls (P > 0.05). Serum level of IgG was significantly lower in patients than in controls (P < 0.05). Type of Candida colonization can change in patients with atopic dermatitis. In addition, these patients have abnormalities in the production of antibodies against Candida albicans that may have a role in the pathogenesis of atopic dermatitis. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/25945349/Evaluation_of_Candida_Colonization_and_Specific_Humoral_Responses_against_Candida_albicans_in_Patients_with_Atopic_Dermatitis_ L2 - https://doi.org/10.1155/2015/849206 DB - PRIME DP - Unbound Medicine ER -