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[Sensitivity and specificity of antigliadine antibodies in the diagnosis of celiac disease in a population of children in Toscana].
Pediatr Med Chir. 1989 May-Jun; 11(3):301-5.PM

Abstract

The aim of this study was to determine the value of IgA and IgG antigliadin antibody test (AGA) for screening, diagnosis and follow-up of coeliac disease. A rapid, simple, sensitive and accurate immunosorbent assay (ELISA) was used to determine AGA IgA and IgG in the sera of patients with untreated coeliac disease (I stage), coeliac patients in gluten withdrawal, healthy controls, children with gastroenterological disorders other than coeliac disease and children with constitutional short stature. In the I stage of coeliac disease the AGA IgA gave a sensitivity of 90.9% and a specificity of 97.9%, the IgG assay resulted in a sensitivity of 100% and a specificity of 82.3%. AGA IgG resulted positive in 17.7% of control disease group, but it's interesting to remark that they had a mean level significantly lower than in coeliac patients. On gluten free diet the titres of AGA IgA returned to normal value in three months, while the AGA IgG showed a slower decrease.

Authors+Show Affiliations

Dipartimento di Pediatria, Università di Firenze, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

2594557

Citation

Rosselli, P, et al. "[Sensitivity and Specificity of Antigliadine Antibodies in the Diagnosis of Celiac Disease in a Population of Children in Toscana]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 11, no. 3, 1989, pp. 301-5.
Rosselli P, Pierattelli M, Ferrari R, et al. [Sensitivity and specificity of antigliadine antibodies in the diagnosis of celiac disease in a population of children in Toscana]. Pediatr Med Chir. 1989;11(3):301-5.
Rosselli, P., Pierattelli, M., Ferrari, R., Rinaldi, R., Rapi, G., Mattei, R., & Noccioli, B. (1989). [Sensitivity and specificity of antigliadine antibodies in the diagnosis of celiac disease in a population of children in Toscana]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 11(3), 301-5.
Rosselli P, et al. [Sensitivity and Specificity of Antigliadine Antibodies in the Diagnosis of Celiac Disease in a Population of Children in Toscana]. Pediatr Med Chir. 1989 May-Jun;11(3):301-5. PubMed PMID: 2594557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sensitivity and specificity of antigliadine antibodies in the diagnosis of celiac disease in a population of children in Toscana]. AU - Rosselli,P, AU - Pierattelli,M, AU - Ferrari,R, AU - Rinaldi,R, AU - Rapi,G, AU - Mattei,R, AU - Noccioli,B, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 301 EP - 5 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 11 IS - 3 N2 - The aim of this study was to determine the value of IgA and IgG antigliadin antibody test (AGA) for screening, diagnosis and follow-up of coeliac disease. A rapid, simple, sensitive and accurate immunosorbent assay (ELISA) was used to determine AGA IgA and IgG in the sera of patients with untreated coeliac disease (I stage), coeliac patients in gluten withdrawal, healthy controls, children with gastroenterological disorders other than coeliac disease and children with constitutional short stature. In the I stage of coeliac disease the AGA IgA gave a sensitivity of 90.9% and a specificity of 97.9%, the IgG assay resulted in a sensitivity of 100% and a specificity of 82.3%. AGA IgG resulted positive in 17.7% of control disease group, but it's interesting to remark that they had a mean level significantly lower than in coeliac patients. On gluten free diet the titres of AGA IgA returned to normal value in three months, while the AGA IgG showed a slower decrease. SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/2594557/[Sensitivity_and_specificity_of_antigliadine_antibodies_in_the_diagnosis_of_celiac_disease_in_a_population_of_children_in_Toscana]_ L2 - https://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -