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Evaluation of hypothalamic dopaminergic function in patients with pituitary prolactinoma.

Abstract

This study was carried out using a dopaminergic agonist (carbidopa plus levodopa, CD + LD) and antagonist (metoclopramide, MCP) respectively for dynamic tests to observe the variations of serum prolactin (PRL), thyrotropin (TSH) and luteinizing hormone (LH) levels in 7 normal women and 11 women with pituitary prolactinoma. It was shown that CD + LD resulted in minimal suppression of serum PRL (18.4 +/- 3.4%) in tumor patients, with this being significantly less than that in normal women (80.7 +/- 4.6%). However, similar degrees of TSH and LH suppression were observed after CD + LD in patients (23.8 +/- 4.2% and 28.2 +/- 2.1%, respectively) and in normal women (27.9 +/- 2.4% and 34.7 +/- 9.0%, respectively). MCP greatly increased PRL levels in the normal women as compared with the patients (892.1 +/- 195.3%, 16.4 +/- 6.5%), but increased TSH and LH levels were much higher in the patients than in the normal women (291.4 +/- 36.1% vs 19.9 +/- 3.3% and 96.9 +/- 7.4% vs 24.9 +/- 5.5%, respectively). It was also found that the levels of TSH or LH after MCP strongly correlated with basal PRL levels in the patients (r = 0.858, P less than 0.001 and r = 0.737, P less than 0.01, respectively). These results indicate that synthesis, turnover and release of hypothalamic dopamine are normal and the hypothalamic tone is relatively high in patients with PRL-secreting pituitary tumors.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2594732

Citation

Xia, P, and Y F. Shi. "Evaluation of Hypothalamic Dopaminergic Function in Patients With Pituitary Prolactinoma." Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo I Hsueh K'o Hsueh Yuan, Chung-kuo Hsieh Ho I K'o Ta Hsueh Hsueh Pao, vol. 4, no. 3, 1989, pp. 121-5.
Xia P, Shi YF. Evaluation of hypothalamic dopaminergic function in patients with pituitary prolactinoma. Proc Chin Acad Med Sci Peking Union Med Coll. 1989;4(3):121-5.
Xia, P., & Shi, Y. F. (1989). Evaluation of hypothalamic dopaminergic function in patients with pituitary prolactinoma. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo I Hsueh K'o Hsueh Yuan, Chung-kuo Hsieh Ho I K'o Ta Hsueh Hsueh Pao, 4(3), 121-5.
Xia P, Shi YF. Evaluation of Hypothalamic Dopaminergic Function in Patients With Pituitary Prolactinoma. Proc Chin Acad Med Sci Peking Union Med Coll. 1989;4(3):121-5. PubMed PMID: 2594732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of hypothalamic dopaminergic function in patients with pituitary prolactinoma. AU - Xia,P, AU - Shi,Y F, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 121 EP - 5 JF - Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao JO - Proc Chin Acad Med Sci Peking Union Med Coll VL - 4 IS - 3 N2 - This study was carried out using a dopaminergic agonist (carbidopa plus levodopa, CD + LD) and antagonist (metoclopramide, MCP) respectively for dynamic tests to observe the variations of serum prolactin (PRL), thyrotropin (TSH) and luteinizing hormone (LH) levels in 7 normal women and 11 women with pituitary prolactinoma. It was shown that CD + LD resulted in minimal suppression of serum PRL (18.4 +/- 3.4%) in tumor patients, with this being significantly less than that in normal women (80.7 +/- 4.6%). However, similar degrees of TSH and LH suppression were observed after CD + LD in patients (23.8 +/- 4.2% and 28.2 +/- 2.1%, respectively) and in normal women (27.9 +/- 2.4% and 34.7 +/- 9.0%, respectively). MCP greatly increased PRL levels in the normal women as compared with the patients (892.1 +/- 195.3%, 16.4 +/- 6.5%), but increased TSH and LH levels were much higher in the patients than in the normal women (291.4 +/- 36.1% vs 19.9 +/- 3.3% and 96.9 +/- 7.4% vs 24.9 +/- 5.5%, respectively). It was also found that the levels of TSH or LH after MCP strongly correlated with basal PRL levels in the patients (r = 0.858, P less than 0.001 and r = 0.737, P less than 0.01, respectively). These results indicate that synthesis, turnover and release of hypothalamic dopamine are normal and the hypothalamic tone is relatively high in patients with PRL-secreting pituitary tumors. SN - 0258-8757 UR - https://www.unboundmedicine.com/medline/citation/2594732/Evaluation_of_hypothalamic_dopaminergic_function_in_patients_with_pituitary_prolactinoma_ L2 - https://medlineplus.gov/pituitarytumors.html DB - PRIME DP - Unbound Medicine ER -