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Membranous nephropathy with solitary immunoglobulin A deposition.
Intern Med. 2015; 54(9):1081-4.IM

Abstract

A 71-year-old woman was admitted with nephrotic syndrome. Light and electron microscopic analyses of renal biopsy tissue showed typical diffuse membranous features. In contrast, granular deposition of immunoglobulin A (IgA), but not IgG, IgM, C3 or C1q, was observed along the capillary walls on immunofluorescence. The patient was pathologically diagnosed with diffuse membranous nephropathy with solitary IgA deposition. Secondary membranous nephropathy was suspected; however, no underlying cause was found. The clinical and pathological findings, except for those of immunofluorescence, were all compatible with a diagnosis of primary membranous nephropathy. This is the first reported case of membranous nephropathy associated with solitary IgA deposition.

Authors+Show Affiliations

Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25948352

Citation

Kobayashi, Mayumi, et al. "Membranous Nephropathy With Solitary Immunoglobulin a Deposition." Internal Medicine (Tokyo, Japan), vol. 54, no. 9, 2015, pp. 1081-4.
Kobayashi M, Usui J, Sakai K, et al. Membranous nephropathy with solitary immunoglobulin A deposition. Intern Med. 2015;54(9):1081-4.
Kobayashi, M., Usui, J., Sakai, K., Mase, K., Iwabuchi, S., Nagata, M., Kobayashi, M., & Yamagata, K. (2015). Membranous nephropathy with solitary immunoglobulin A deposition. Internal Medicine (Tokyo, Japan), 54(9), 1081-4. https://doi.org/10.2169/internalmedicine.54.3655
Kobayashi M, et al. Membranous Nephropathy With Solitary Immunoglobulin a Deposition. Intern Med. 2015;54(9):1081-4. PubMed PMID: 25948352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Membranous nephropathy with solitary immunoglobulin A deposition. AU - Kobayashi,Mayumi, AU - Usui,Joichi, AU - Sakai,Kentaro, AU - Mase,Kaori, AU - Iwabuchi,Satoshi, AU - Nagata,Michio, AU - Kobayashi,Masaki, AU - Yamagata,Kunihiro, Y1 - 2015/05/01/ PY - 2015/5/8/entrez PY - 2015/5/8/pubmed PY - 2015/9/30/medline SP - 1081 EP - 4 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 54 IS - 9 N2 - A 71-year-old woman was admitted with nephrotic syndrome. Light and electron microscopic analyses of renal biopsy tissue showed typical diffuse membranous features. In contrast, granular deposition of immunoglobulin A (IgA), but not IgG, IgM, C3 or C1q, was observed along the capillary walls on immunofluorescence. The patient was pathologically diagnosed with diffuse membranous nephropathy with solitary IgA deposition. Secondary membranous nephropathy was suspected; however, no underlying cause was found. The clinical and pathological findings, except for those of immunofluorescence, were all compatible with a diagnosis of primary membranous nephropathy. This is the first reported case of membranous nephropathy associated with solitary IgA deposition. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/25948352/Membranous_nephropathy_with_solitary_immunoglobulin_A_deposition_ L2 - https://dx.doi.org/10.2169/internalmedicine.54.3655 DB - PRIME DP - Unbound Medicine ER -