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Assessing pentobarbital preference in normal volunteers using a cumulative dosing procedure.
Psychopharmacology (Berl). 1989; 99(3):416-21.P

Abstract

Preference for pentobarbital was assessed in 12 normal healthy volunteers using a seven-session cumulative dosing choice procedure. On the first four sessions subjects sampled the drug and a placebo, and on the last three sessions they chose the substance they preferred. During each of the sampling sessions they ingested, at 30-min intervals, five capsules containing either pentobarbital (30 mg per dose) or placebo. During the choice sessions subjects first chose which capsules they preferred to take (drug or placebo), and then took from one to seven of these capsules, separated by 30 min between ingestions. Self-report measures of subjective effects were obtained at regular intervals during each session. Subjects chose the pentobarbital-containing capsules on average 52% of choice sessions, and ingested an average total dose of 132 mg. Although the drug produced only modest, sedative-like subjective and behavioral effects and there was little evidence of euphoric effects in the group as a whole, individual differences in drug liking and choice were observed. The results are discussed in terms of variables that affect the reinforcing effects of pentobarbital in normal volunteers, and they are contrasted to previous findings using this procedure with other sedative drugs.

Authors+Show Affiliations

Department of Psychiatry, Pritzker School of Medicine, University of Chicago, IL 60637.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2594908

Citation

de Wit, H, et al. "Assessing Pentobarbital Preference in Normal Volunteers Using a Cumulative Dosing Procedure." Psychopharmacology, vol. 99, no. 3, 1989, pp. 416-21.
de Wit H, Pierri J, Johanson CE. Assessing pentobarbital preference in normal volunteers using a cumulative dosing procedure. Psychopharmacology (Berl). 1989;99(3):416-21.
de Wit, H., Pierri, J., & Johanson, C. E. (1989). Assessing pentobarbital preference in normal volunteers using a cumulative dosing procedure. Psychopharmacology, 99(3), 416-21.
de Wit H, Pierri J, Johanson CE. Assessing Pentobarbital Preference in Normal Volunteers Using a Cumulative Dosing Procedure. Psychopharmacology (Berl). 1989;99(3):416-21. PubMed PMID: 2594908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessing pentobarbital preference in normal volunteers using a cumulative dosing procedure. AU - de Wit,H, AU - Pierri,J, AU - Johanson,C E, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 416 EP - 21 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 99 IS - 3 N2 - Preference for pentobarbital was assessed in 12 normal healthy volunteers using a seven-session cumulative dosing choice procedure. On the first four sessions subjects sampled the drug and a placebo, and on the last three sessions they chose the substance they preferred. During each of the sampling sessions they ingested, at 30-min intervals, five capsules containing either pentobarbital (30 mg per dose) or placebo. During the choice sessions subjects first chose which capsules they preferred to take (drug or placebo), and then took from one to seven of these capsules, separated by 30 min between ingestions. Self-report measures of subjective effects were obtained at regular intervals during each session. Subjects chose the pentobarbital-containing capsules on average 52% of choice sessions, and ingested an average total dose of 132 mg. Although the drug produced only modest, sedative-like subjective and behavioral effects and there was little evidence of euphoric effects in the group as a whole, individual differences in drug liking and choice were observed. The results are discussed in terms of variables that affect the reinforcing effects of pentobarbital in normal volunteers, and they are contrasted to previous findings using this procedure with other sedative drugs. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/2594908/Assessing_pentobarbital_preference_in_normal_volunteers_using_a_cumulative_dosing_procedure_ DB - PRIME DP - Unbound Medicine ER -