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Sinonasal extramedullary plasmacytoma: a population-based incidence and survival analysis.
Int Forum Allergy Rhinol. 2015 Sep; 5(9):862-9.IF

Abstract

BACKGROUND

Sinonasal extramedullary plasmacytoma (SN-EMP) is a rare plasma cell neoplasm. Published literature on this tumor largely consists of case reports and case-series with small sample sizes. This study analyzed population-based data on SN-EMP patients to understand demographic and clinical features as well as incidence and survival trends.

METHODS

The Surveillance, Epidemiology, and End Results (SEER) database was queried for SN-EMP and other head and neck EMP (HN-EMP) cases from 1973 to 2011. Cases were analyzed to determine patient demographics, initial treatment modality, and survival outcomes.

RESULTS

Of 778 patients identified with EMP in the head and neck region, 367 patients had SN-EMP and 411 had other HN-EMP. There was a strong male predilection found, with a male-to-female ratio of 3.65:1 in the SN-EMP group and 1.87:1 in the other HN-EMP group. The majority of the patients presented with localized disease in both SN-EMP (84.4%) and other HN-EMP (81.0%) groups. The most common treatment modality reported in this database was surgery with adjuvant radiotherapy in both SN-EMP (46.3%) and other HN-EMP (38.9%) groups, followed by radiotherapy alone (SN-EMP: 40.7%; other HN-EMP: 34.2%). Five-year and 10-year disease-specific survival rates were comparable between SN-EMP (88.2% and 83.3%, respectively) and other HN-EMP (90.0% and 87.4%, respectively) (p = 0.6016 and p = 0.4015, respectively).

CONCLUSION

This study analyzed the largest cohort of SN-EMP patients to date. There was no statistically significant survival advantage found for any 1 particular treatment modality over other treatment modalities in both SN-EMP and other HN-EMP.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ.Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ. Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ.Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ. Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ. Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25951123

Citation

Patel, Tapan D., et al. "Sinonasal Extramedullary Plasmacytoma: a Population-based Incidence and Survival Analysis." International Forum of Allergy & Rhinology, vol. 5, no. 9, 2015, pp. 862-9.
Patel TD, Vázquez A, Choudhary MM, et al. Sinonasal extramedullary plasmacytoma: a population-based incidence and survival analysis. Int Forum Allergy Rhinol. 2015;5(9):862-9.
Patel, T. D., Vázquez, A., Choudhary, M. M., Kam, D., Baredes, S., & Eloy, J. A. (2015). Sinonasal extramedullary plasmacytoma: a population-based incidence and survival analysis. International Forum of Allergy & Rhinology, 5(9), 862-9. https://doi.org/10.1002/alr.21544
Patel TD, et al. Sinonasal Extramedullary Plasmacytoma: a Population-based Incidence and Survival Analysis. Int Forum Allergy Rhinol. 2015;5(9):862-9. PubMed PMID: 25951123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sinonasal extramedullary plasmacytoma: a population-based incidence and survival analysis. AU - Patel,Tapan D, AU - Vázquez,Alejandro, AU - Choudhary,Moaz M, AU - Kam,David, AU - Baredes,Soly, AU - Eloy,Jean Anderson, Y1 - 2015/05/07/ PY - 2015/01/01/received PY - 2015/02/17/revised PY - 2015/03/18/accepted PY - 2015/5/8/entrez PY - 2015/5/8/pubmed PY - 2016/6/30/medline KW - SEER KW - demographic KW - disease-specific survival KW - extramedullary plasmacytoma KW - incidence KW - relative survival KW - sinonasal malignancy SP - 862 EP - 9 JF - International forum of allergy & rhinology JO - Int Forum Allergy Rhinol VL - 5 IS - 9 N2 - BACKGROUND: Sinonasal extramedullary plasmacytoma (SN-EMP) is a rare plasma cell neoplasm. Published literature on this tumor largely consists of case reports and case-series with small sample sizes. This study analyzed population-based data on SN-EMP patients to understand demographic and clinical features as well as incidence and survival trends. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried for SN-EMP and other head and neck EMP (HN-EMP) cases from 1973 to 2011. Cases were analyzed to determine patient demographics, initial treatment modality, and survival outcomes. RESULTS: Of 778 patients identified with EMP in the head and neck region, 367 patients had SN-EMP and 411 had other HN-EMP. There was a strong male predilection found, with a male-to-female ratio of 3.65:1 in the SN-EMP group and 1.87:1 in the other HN-EMP group. The majority of the patients presented with localized disease in both SN-EMP (84.4%) and other HN-EMP (81.0%) groups. The most common treatment modality reported in this database was surgery with adjuvant radiotherapy in both SN-EMP (46.3%) and other HN-EMP (38.9%) groups, followed by radiotherapy alone (SN-EMP: 40.7%; other HN-EMP: 34.2%). Five-year and 10-year disease-specific survival rates were comparable between SN-EMP (88.2% and 83.3%, respectively) and other HN-EMP (90.0% and 87.4%, respectively) (p = 0.6016 and p = 0.4015, respectively). CONCLUSION: This study analyzed the largest cohort of SN-EMP patients to date. There was no statistically significant survival advantage found for any 1 particular treatment modality over other treatment modalities in both SN-EMP and other HN-EMP. SN - 2042-6984 UR - https://www.unboundmedicine.com/medline/citation/25951123/Sinonasal_extramedullary_plasmacytoma:_a_population_based_incidence_and_survival_analysis_ L2 - https://doi.org/10.1002/alr.21544 DB - PRIME DP - Unbound Medicine ER -