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Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis.
Cancer Causes Control. 2015 Jul; 26(7):1027-35.CC

Abstract

PURPOSE

Gastric colonization with Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of pancreatic cancer, but results of epidemiological studies have been inconclusive. We analyzed data from the Queensland Pancreatic Cancer Study, an Australian population-based case-control study, and incorporated our findings into an updated meta-analysis.

METHODS

Blood samples were obtained from 580 patients and 626 controls, and enzyme-linked immunosorbent assay kits were used to determine seropositivity to H. pylori and its virulence protein, cytotoxin-associated gene A (CagA). Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using logistic regression. Results were incorporated into a meta-analysis along with results of studies identified through systematic literature review. Adjusted ORs and 95 % CIs were calculated using the DerSimonian and Laird random-effects model.

RESULTS

No overall association was observed between H. pylori seropositivity and risk of pancreatic cancer (OR 1.00; 95 % CI 0.74-1.35). Nonsignificantly decreased pancreatic cancer risk was observed with CagA seropositivity (OR 0.74; 95 % CI 0.48-1.15) and increased risk with CagA-negative H. pylori seropositivity (OR 1.23; 95 % CI 0.83-1.82). Ten studies were included in the meta-analysis. There was no significant overall association between H. pylori seropositivity and pancreatic cancer risk (OR 1.13; 95 % CI 0.86-1.50), but evidence of CagA strain-specific associations (OR 0.78; 95 % CI 0.67-0.91 and OR 1.30; 95 % CI 1.02-1.65 for CagA-positive and CagA-negative strains, respectively).

CONCLUSIONS

Our results provide further evidence for the existence of strain-specific associations between H. pylori and pancreatic cancer.

Authors+Show Affiliations

Department of Population Health, Royal Brisbane Hospital, QIMR Berghofer Medical Research Institute, Locked Bag 2000, Brisbane, QLD, Australia, Annaka.Schulte@qimrberghofer.edu.au.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

25951801

Citation

Schulte, Annaka, et al. "Association Between Helicobacter Pylori and Pancreatic Cancer Risk: a Meta-analysis." Cancer Causes & Control : CCC, vol. 26, no. 7, 2015, pp. 1027-35.
Schulte A, Pandeya N, Fawcett J, et al. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes Control. 2015;26(7):1027-35.
Schulte, A., Pandeya, N., Fawcett, J., Fritschi, L., Risch, H. A., Webb, P. M., Whiteman, D. C., & Neale, R. E. (2015). Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes & Control : CCC, 26(7), 1027-35. https://doi.org/10.1007/s10552-015-0595-3
Schulte A, et al. Association Between Helicobacter Pylori and Pancreatic Cancer Risk: a Meta-analysis. Cancer Causes Control. 2015;26(7):1027-35. PubMed PMID: 25951801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. AU - Schulte,Annaka, AU - Pandeya,Nirmala, AU - Fawcett,Jonathan, AU - Fritschi,Lin, AU - Risch,Harvey A, AU - Webb,Penelope M, AU - Whiteman,David C, AU - Neale,Rachel E, Y1 - 2015/05/08/ PY - 2014/10/08/received PY - 2015/04/27/accepted PY - 2015/5/9/entrez PY - 2015/5/9/pubmed PY - 2016/4/5/medline SP - 1027 EP - 35 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 7 N2 - PURPOSE: Gastric colonization with Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of pancreatic cancer, but results of epidemiological studies have been inconclusive. We analyzed data from the Queensland Pancreatic Cancer Study, an Australian population-based case-control study, and incorporated our findings into an updated meta-analysis. METHODS: Blood samples were obtained from 580 patients and 626 controls, and enzyme-linked immunosorbent assay kits were used to determine seropositivity to H. pylori and its virulence protein, cytotoxin-associated gene A (CagA). Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using logistic regression. Results were incorporated into a meta-analysis along with results of studies identified through systematic literature review. Adjusted ORs and 95 % CIs were calculated using the DerSimonian and Laird random-effects model. RESULTS: No overall association was observed between H. pylori seropositivity and risk of pancreatic cancer (OR 1.00; 95 % CI 0.74-1.35). Nonsignificantly decreased pancreatic cancer risk was observed with CagA seropositivity (OR 0.74; 95 % CI 0.48-1.15) and increased risk with CagA-negative H. pylori seropositivity (OR 1.23; 95 % CI 0.83-1.82). Ten studies were included in the meta-analysis. There was no significant overall association between H. pylori seropositivity and pancreatic cancer risk (OR 1.13; 95 % CI 0.86-1.50), but evidence of CagA strain-specific associations (OR 0.78; 95 % CI 0.67-0.91 and OR 1.30; 95 % CI 1.02-1.65 for CagA-positive and CagA-negative strains, respectively). CONCLUSIONS: Our results provide further evidence for the existence of strain-specific associations between H. pylori and pancreatic cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25951801/Association_between_Helicobacter_pylori_and_pancreatic_cancer_risk:_a_meta_analysis_ L2 - https://doi.org/10.1007/s10552-015-0595-3 DB - PRIME DP - Unbound Medicine ER -