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Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study.
Eur J Nutr 2016; 55(3):1069-79EJ

Abstract

PURPOSE

To test whether the inflammatory potential of diet, as measured using the dietary inflammatory index (DII), is associated with risk of lung cancer or other respiratory conditions and to compare results obtained with those based on the aMED score, an established dietary index that measures adherence to the traditional Mediterranean diet.

METHODS

In 4336 heavy smokers enrolled in a prospective, non-randomized lung cancer screening program, we measured participants' diets at baseline using a self-administered food frequency questionnaire from which dietary scores were calculated. Cox proportional hazards and logistic regression models were used to assess association between the dietary indices and lung cancer diagnosed during annual screening, and other respiratory outcomes that were recorded at baseline, respectively.

RESULTS

In multivariable analysis, adjusted for baseline lung cancer risk (estimated from age, sex, smoking history, and asbestos exposure) and total energy, both DII and aMED scores were associated with dyspnoea (p trend = 0.046 and 0.02, respectively) and radiological evidence of emphysema (p trend = 0.0002 and 0.02). After mutual adjustment of the two dietary scores, only the association between DII and radiological evidence of emphysema (Q4 vs. Q1, OR 1.30, 95 % CI 1.01-1.67, p trend = 0.012) remained statistically significant. At univariate analysis, both DII and aMED were associated with lung cancer risk, but in fully adjusted multivariate analysis, only the association with aMED remained statistically significant (p trend = 0.04).

CONCLUSIONS

Among heavy smokers, a pro-inflammatory diet, as indicated by increasing DII score, is associated with dyspnoea and radiological evidence of emphysema. A traditional Mediterranean diet, which is associated with a lower DII, may lower lung cancer risk.

Authors+Show Affiliations

Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ramusio 1, 20141, Milan, Italy. patrick.maisonneuve@ieo.it.Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.Division of Radiology, European Institute of Oncology, Milan, Italy. Department of Health Sciences, University of Milan, Milan, Italy.Division of Radiology, European Institute of Oncology, Milan, Italy.Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy.Department of Health Sciences, University of Milan, Milan, Italy. Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy.Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy.Division of Thoracic and General Surgery, Humanitas Research Hospital, Rozzano, Italy.Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ramusio 1, 20141, Milan, Italy.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25953452

Citation

Maisonneuve, Patrick, et al. "Dietary Inflammatory Index and Risk of Lung Cancer and Other Respiratory Conditions Among Heavy Smokers in the COSMOS Screening Study." European Journal of Nutrition, vol. 55, no. 3, 2016, pp. 1069-79.
Maisonneuve P, Shivappa N, Hébert JR, et al. Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study. Eur J Nutr. 2016;55(3):1069-79.
Maisonneuve, P., Shivappa, N., Hébert, J. R., Bellomi, M., Rampinelli, C., Bertolotti, R., ... Gnagnarella, P. (2016). Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study. European Journal of Nutrition, 55(3), pp. 1069-79. doi:10.1007/s00394-015-0920-3.
Maisonneuve P, et al. Dietary Inflammatory Index and Risk of Lung Cancer and Other Respiratory Conditions Among Heavy Smokers in the COSMOS Screening Study. Eur J Nutr. 2016;55(3):1069-79. PubMed PMID: 25953452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study. AU - Maisonneuve,Patrick, AU - Shivappa,Nitin, AU - Hébert,James R, AU - Bellomi,Massimo, AU - Rampinelli,Cristiano, AU - Bertolotti,Raffaella, AU - Spaggiari,Lorenzo, AU - Palli,Domenico, AU - Veronesi,Giulia, AU - Gnagnarella,Patrizia, Y1 - 2015/05/08/ PY - 2014/10/29/received PY - 2015/04/27/accepted PY - 2015/5/9/entrez PY - 2015/5/9/pubmed PY - 2017/1/24/medline KW - Dietary inflammatory index KW - Dyspnoea KW - Emphysema KW - Lung cancer KW - Lung function KW - Mediterranean diet SP - 1069 EP - 79 JF - European journal of nutrition JO - Eur J Nutr VL - 55 IS - 3 N2 - PURPOSE: To test whether the inflammatory potential of diet, as measured using the dietary inflammatory index (DII), is associated with risk of lung cancer or other respiratory conditions and to compare results obtained with those based on the aMED score, an established dietary index that measures adherence to the traditional Mediterranean diet. METHODS: In 4336 heavy smokers enrolled in a prospective, non-randomized lung cancer screening program, we measured participants' diets at baseline using a self-administered food frequency questionnaire from which dietary scores were calculated. Cox proportional hazards and logistic regression models were used to assess association between the dietary indices and lung cancer diagnosed during annual screening, and other respiratory outcomes that were recorded at baseline, respectively. RESULTS: In multivariable analysis, adjusted for baseline lung cancer risk (estimated from age, sex, smoking history, and asbestos exposure) and total energy, both DII and aMED scores were associated with dyspnoea (p trend = 0.046 and 0.02, respectively) and radiological evidence of emphysema (p trend = 0.0002 and 0.02). After mutual adjustment of the two dietary scores, only the association between DII and radiological evidence of emphysema (Q4 vs. Q1, OR 1.30, 95 % CI 1.01-1.67, p trend = 0.012) remained statistically significant. At univariate analysis, both DII and aMED were associated with lung cancer risk, but in fully adjusted multivariate analysis, only the association with aMED remained statistically significant (p trend = 0.04). CONCLUSIONS: Among heavy smokers, a pro-inflammatory diet, as indicated by increasing DII score, is associated with dyspnoea and radiological evidence of emphysema. A traditional Mediterranean diet, which is associated with a lower DII, may lower lung cancer risk. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/25953452/Dietary_inflammatory_index_and_risk_of_lung_cancer_and_other_respiratory_conditions_among_heavy_smokers_in_the_COSMOS_screening_study_ L2 - https://dx.doi.org/10.1007/s00394-015-0920-3 DB - PRIME DP - Unbound Medicine ER -