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Familial colorectal cancer.
Intern Med J 2015; 45(5):482-91IM

Abstract

Identifying individuals with a genetic predisposition to developing familial colorectal cancer (CRC) is crucial to the management of the affected individual and their family. In order to do so, the physician requires an understanding of the different gene mutations and clinical manifestations of familial CRC. This review summarises the genetics, clinical manifestations and management of the known familial CRC syndromes, specifically Lynch syndrome, familial adenomatous polyposis, MUTYH-associated neoplasia, juvenile polyposis syndrome and Peutz-Jeghers syndrome. An individual suspected of having a familial CRC with an underlying genetic predisposition should be referred to a familial cancer centre to enable pre-test counselling and appropriate follow up.

Authors+Show Affiliations

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Familial Cancer Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia.Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.Familial Cancer Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25955461

Citation

Lung, M S., et al. "Familial Colorectal Cancer." Internal Medicine Journal, vol. 45, no. 5, 2015, pp. 482-91.
Lung MS, Trainer AH, Campbell I, et al. Familial colorectal cancer. Intern Med J. 2015;45(5):482-91.
Lung, M. S., Trainer, A. H., Campbell, I., & Lipton, L. (2015). Familial colorectal cancer. Internal Medicine Journal, 45(5), pp. 482-91. doi:10.1111/imj.12736.
Lung MS, et al. Familial Colorectal Cancer. Intern Med J. 2015;45(5):482-91. PubMed PMID: 25955461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial colorectal cancer. AU - Lung,M S, AU - Trainer,A H, AU - Campbell,I, AU - Lipton,L, PY - 2014/08/27/received PY - 2015/02/24/accepted PY - 2015/5/9/entrez PY - 2015/5/9/pubmed PY - 2016/3/2/medline KW - adenomatous polyposis coli KW - colorectal neoplasm KW - hereditary KW - hereditary nonpolyposis KW - neoplastic syndrome SP - 482 EP - 91 JF - Internal medicine journal JO - Intern Med J VL - 45 IS - 5 N2 - Identifying individuals with a genetic predisposition to developing familial colorectal cancer (CRC) is crucial to the management of the affected individual and their family. In order to do so, the physician requires an understanding of the different gene mutations and clinical manifestations of familial CRC. This review summarises the genetics, clinical manifestations and management of the known familial CRC syndromes, specifically Lynch syndrome, familial adenomatous polyposis, MUTYH-associated neoplasia, juvenile polyposis syndrome and Peutz-Jeghers syndrome. An individual suspected of having a familial CRC with an underlying genetic predisposition should be referred to a familial cancer centre to enable pre-test counselling and appropriate follow up. SN - 1445-5994 UR - https://www.unboundmedicine.com/medline/citation/25955461/Familial_colorectal_cancer_ L2 - https://doi.org/10.1111/imj.12736 DB - PRIME DP - Unbound Medicine ER -