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Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: the ESTELLE study.
Cancer Causes Control 2015; 26(7):1003-17CC

Abstract

PURPOSE

To investigate the role of parental smoking during pre-conception and pregnancy, maternal beverage consumption (alcohol, coffee and tea) during pregnancy and their possible interactions, in the etiology of childhood acute leukemia (CL).

METHODS

The ESTELLE study included 747 cases of CL [636 cases of acute lymphoblastic leukemia (ALL) and 100 cases of acute myeloblastic leukemia (AML)] diagnosed in France in 2010-2011 and 1,421 population controls frequency-matched with the cases on age and gender. Data were obtained from structured telephone questionnaires administered to the mothers. The odds ratios (OR) and their 95 % confidence intervals were estimated using unconditional logistic regression models adjusted for potential confounders.

RESULTS

AML, but not ALL, was non-significantly associated with alcohol drinking during pregnancy [OR = 1.3 (0.8-2.0)] with a significant positive dose-response trend (p-trend = 0.02). Pre-conception paternal smoking was significantly associated with ALL [OR = 1.2 (1.1-1.5)] and AML [OR = 1.5 (1.0-2.3)]. CL was not associated with maternal smoking [OR = 1.0 (0.8-1.2)], or maternal coffee [OR = 0.9 (0.8-1.1)] or tea drinking [OR = 0.9 (0.8-1.1)] during pregnancy. However, a high consumption of coffee (>2 cups/day) was significantly associated with ALL [OR = 1.3 (1.0-1.8)].

CONCLUSIONS

The findings constitute additional evidence that maternal alcohol drinking during pregnancy may be involved in AML, and that paternal smoking before pregnancy may be a risk factor for CL. The role of maternal coffee drinking in CL remains unclear and should be investigated further in consortium analyses and in large birth cohort studies with exposure assessment more contemporaneous with the exposure, before the occurrence of the disease.

Authors+Show Affiliations

INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif, France, laurent.orsi@inserm.fr.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25956268

Citation

Orsi, L, et al. "Parental Smoking, Maternal Alcohol, Coffee and Tea Consumption During Pregnancy, and Childhood Acute Leukemia: the ESTELLE Study." Cancer Causes & Control : CCC, vol. 26, no. 7, 2015, pp. 1003-17.
Orsi L, Rudant J, Ajrouche R, et al. Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: the ESTELLE study. Cancer Causes Control. 2015;26(7):1003-17.
Orsi, L., Rudant, J., Ajrouche, R., Leverger, G., Baruchel, A., Nelken, B., ... Clavel, J. (2015). Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: the ESTELLE study. Cancer Causes & Control : CCC, 26(7), pp. 1003-17. doi:10.1007/s10552-015-0593-5.
Orsi L, et al. Parental Smoking, Maternal Alcohol, Coffee and Tea Consumption During Pregnancy, and Childhood Acute Leukemia: the ESTELLE Study. Cancer Causes Control. 2015;26(7):1003-17. PubMed PMID: 25956268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: the ESTELLE study. AU - Orsi,L, AU - Rudant,J, AU - Ajrouche,R, AU - Leverger,G, AU - Baruchel,A, AU - Nelken,B, AU - Pasquet,M, AU - Michel,G, AU - Bertrand,Y, AU - Ducassou,S, AU - Gandemer,V, AU - Lutz,P, AU - Saumet,L, AU - Moreau,P, AU - Hemon,D, AU - Clavel,J, Y1 - 2015/05/09/ PY - 2015/01/16/received PY - 2015/04/22/accepted PY - 2015/5/10/entrez PY - 2015/5/10/pubmed PY - 2016/4/5/medline SP - 1003 EP - 17 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 7 N2 - PURPOSE: To investigate the role of parental smoking during pre-conception and pregnancy, maternal beverage consumption (alcohol, coffee and tea) during pregnancy and their possible interactions, in the etiology of childhood acute leukemia (CL). METHODS: The ESTELLE study included 747 cases of CL [636 cases of acute lymphoblastic leukemia (ALL) and 100 cases of acute myeloblastic leukemia (AML)] diagnosed in France in 2010-2011 and 1,421 population controls frequency-matched with the cases on age and gender. Data were obtained from structured telephone questionnaires administered to the mothers. The odds ratios (OR) and their 95 % confidence intervals were estimated using unconditional logistic regression models adjusted for potential confounders. RESULTS: AML, but not ALL, was non-significantly associated with alcohol drinking during pregnancy [OR = 1.3 (0.8-2.0)] with a significant positive dose-response trend (p-trend = 0.02). Pre-conception paternal smoking was significantly associated with ALL [OR = 1.2 (1.1-1.5)] and AML [OR = 1.5 (1.0-2.3)]. CL was not associated with maternal smoking [OR = 1.0 (0.8-1.2)], or maternal coffee [OR = 0.9 (0.8-1.1)] or tea drinking [OR = 0.9 (0.8-1.1)] during pregnancy. However, a high consumption of coffee (>2 cups/day) was significantly associated with ALL [OR = 1.3 (1.0-1.8)]. CONCLUSIONS: The findings constitute additional evidence that maternal alcohol drinking during pregnancy may be involved in AML, and that paternal smoking before pregnancy may be a risk factor for CL. The role of maternal coffee drinking in CL remains unclear and should be investigated further in consortium analyses and in large birth cohort studies with exposure assessment more contemporaneous with the exposure, before the occurrence of the disease. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25956268/Parental_smoking_maternal_alcohol_coffee_and_tea_consumption_during_pregnancy_and_childhood_acute_leukemia:_the_ESTELLE_study_ L2 - https://doi.org/10.1007/s10552-015-0593-5 DB - PRIME DP - Unbound Medicine ER -