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Cigarette smoking and risk of hip fracture in women: a meta-analysis of prospective cohort studies.
Injury 2015; 46(7):1333-40I

Abstract

BACKGROUND AND OBJECTIVES

Whether cigarette smoking can increase the risk of hip fracture in women is unclear. This meta-analysis, which pooled results from 10 prospective cohort studies, was performed to derive a more precise estimation between cigarette smoking and the risk of hip fracture in women.

MATERIALS AND METHODS

Pubmed, Cochrane Central Register of Controlled Trials and ISI Web of Science were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association among 10 studies. The pooled risk estimates were calculated by using both random- and fixed-effects model. Heterogeneity among articles and their publications bias were also tested. All of the statistical analyses were performed using the software programs STATA (version 12.0).

RESULTS

Relative risk was significantly increased in current female smokers (pooled RR, 1.30; 95%CI, 1.16-1.45). The association was significant among the high-dose smokers (more than 15 cigarettes per day) while not among the low-does smokers (less than 15 cigarettes per day). Omission of any single study had little effect on the pooled risk estimate. Former smokers had a similar RR of hip fracture (RR, 1.02; 95%CI, 0.93-1.11) to published papers. Smoking cessation for ≥10 years leads to a significant decline in risk.

CONCLUSIONS

Smoking is associated with an increased hip fracture risk in women. Cessation of smoking for ≥10 years had a decreased impact on risk of hip fracture. Given the inconsistency among the studies in the choice of adjustments, the associations between cigarette smoking and risk of hip fracture in women await further investigation.

Authors+Show Affiliations

Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: GuangSi_S@163.com.Department of Image, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: Yong_L3@163.com.Department of Orthopaedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address: GuoY_Z@163.com.Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: HBinZh@163.com.Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: ZongGangX@163.com.Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: WeiXu088@163.COM.Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: HaiN_Ch@126.com.Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: QiRongD@163.com.Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: YouJ_XU@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25956674

Citation

Shen, Guang Si, et al. "Cigarette Smoking and Risk of Hip Fracture in Women: a Meta-analysis of Prospective Cohort Studies." Injury, vol. 46, no. 7, 2015, pp. 1333-40.
Shen GS, Li Y, Zhao G, et al. Cigarette smoking and risk of hip fracture in women: a meta-analysis of prospective cohort studies. Injury. 2015;46(7):1333-40.
Shen, G. S., Li, Y., Zhao, G., Zhou, H. B., Xie, Z. G., Xu, W., ... Xu, Y. J. (2015). Cigarette smoking and risk of hip fracture in women: a meta-analysis of prospective cohort studies. Injury, 46(7), pp. 1333-40. doi:10.1016/j.injury.2015.04.008.
Shen GS, et al. Cigarette Smoking and Risk of Hip Fracture in Women: a Meta-analysis of Prospective Cohort Studies. Injury. 2015;46(7):1333-40. PubMed PMID: 25956674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and risk of hip fracture in women: a meta-analysis of prospective cohort studies. AU - Shen,Guang Si, AU - Li,Yong, AU - Zhao,GuoYang, AU - Zhou,Hai Bin, AU - Xie,Zong Gang, AU - Xu,Wei, AU - Chen,Hai Nan, AU - Dong,Qi Rong, AU - Xu,You Jia, Y1 - 2015/04/20/ PY - 2014/12/31/received PY - 2015/03/22/revised PY - 2015/04/06/accepted PY - 2015/5/10/entrez PY - 2015/5/10/pubmed PY - 2016/6/9/medline KW - Hip fractures KW - Meta-analysis KW - Osteoporosis KW - Smoking KW - Women SP - 1333 EP - 40 JF - Injury JO - Injury VL - 46 IS - 7 N2 - BACKGROUND AND OBJECTIVES: Whether cigarette smoking can increase the risk of hip fracture in women is unclear. This meta-analysis, which pooled results from 10 prospective cohort studies, was performed to derive a more precise estimation between cigarette smoking and the risk of hip fracture in women. MATERIALS AND METHODS: Pubmed, Cochrane Central Register of Controlled Trials and ISI Web of Science were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association among 10 studies. The pooled risk estimates were calculated by using both random- and fixed-effects model. Heterogeneity among articles and their publications bias were also tested. All of the statistical analyses were performed using the software programs STATA (version 12.0). RESULTS: Relative risk was significantly increased in current female smokers (pooled RR, 1.30; 95%CI, 1.16-1.45). The association was significant among the high-dose smokers (more than 15 cigarettes per day) while not among the low-does smokers (less than 15 cigarettes per day). Omission of any single study had little effect on the pooled risk estimate. Former smokers had a similar RR of hip fracture (RR, 1.02; 95%CI, 0.93-1.11) to published papers. Smoking cessation for ≥10 years leads to a significant decline in risk. CONCLUSIONS: Smoking is associated with an increased hip fracture risk in women. Cessation of smoking for ≥10 years had a decreased impact on risk of hip fracture. Given the inconsistency among the studies in the choice of adjustments, the associations between cigarette smoking and risk of hip fracture in women await further investigation. SN - 1879-0267 UR - https://www.unboundmedicine.com/medline/citation/25956674/Cigarette_smoking_and_risk_of_hip_fracture_in_women:_a_meta_analysis_of_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-1383(15)00204-1 DB - PRIME DP - Unbound Medicine ER -