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Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis.
Surgery. 2015 Jun; 157(6):1028-45.S

Abstract

IMPORTANCE

Bleeding esophageal varices has been studied extensively, but bleeding gastric varices (BGV) has received much less investigation. However, BGV has been reported in ≤ 30% of patients with acute variceal bleeding. In our studies of 1,836 bleeding cirrhotics, 12.7% were bleeding from gastric varices. BGV mortality rate of 45-55% has been reported. The BGV literature has mainly involved retrospective case reports, often with short-term follow-up.

OBJECTIVE

We sought to describe the results of a prospective, randomized, controlled trial (RCT) in unselected, consecutive patients with BGV comparing endoscopic therapy (ET) with portacaval shunt (PCS; n = 518), and later comparing emergency transjugular intrahepatic portosystemic shunt (TIPS) with emergency portacaval shunt (EPCS; n = 70).

DESIGN, SETTING, AND PARTICIPANTS

Initially, our RCT involved 518 patients with BGV comparing ET with direct PCS regarding control of bleeding, mortality rate, and disability. When entry of patients ended, the RCT was expanded to compare emergency TIPS with EPCS (n = 70). This RCT of BGV was separate from our other RCTs of bleeding esophageal varices.

INTERVENTIONS

Initially, ET was compared with PCS. In the second part of our RCT, emergency TIPS was compared with emergency PCS (EPCS).

MAIN OUTCOME MEASURES

Outcomes were survival, control of bleeding, portal-systemic encephalopathy (PSE), quality of life, and direct costs of care. In the RCT of ET versus PCS, 28 and 30%, respectively, were in Child class C. In the expanded RCT of TIPS versus EPCS, 40 and 41%, respectively, were in Child class C. Permanent control of BGV was achieved in 97-100% of patients treated by emergency or elective PCS, compared with 27-29% by ET. TIPS was even less effective, achieving long-term control of BGV in only 6%. Survival rates after PCS were greater at all time intervals and in all Child classes (P < .001). Repeated episodes of PSE occurred in 50% of TIPS patients, 16-17% treated by ET, and 8-11% treated by PCS. Shunt stenosis or occlusion occurred in 67% of TIPS patients, in contrast with 0-2% of PCS patients.

CONCLUSION

These results support the conclusion that PCS is uniformly effective, whereas ET and TIPS are not very effective.

Authors+Show Affiliations

Department of Surgery, University of California, San Diego Medical Center, San Diego, CA. Electronic address: morloff@ucsd.edu.Department of Surgery, University of California, San Diego Medical Center, San Diego, CA.Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego Medical Center, San Diego, CA.Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego Medical Center, San Diego, CA.Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego Medical Center, San Diego, CA.Department of Family and Preventive Medicine/Biostatistics and Bioinformatics, University of California, San Diego Medical Center, San Diego, CA.Department of Surgery, University of California, San Diego Medical Center, San Diego, CA.Department of Surgery, University of California, San Diego Medical Center, San Diego, CA.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25957003

Citation

Orloff, Marshall J., et al. "Randomized Trials of Endoscopic Therapy and Transjugular Intrahepatic Portosystemic Shunt Versus Portacaval Shunt for Emergency and Elective Treatment of Bleeding Gastric Varices in Cirrhosis." Surgery, vol. 157, no. 6, 2015, pp. 1028-45.
Orloff MJ, Hye RJ, Wheeler HO, et al. Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis. Surgery. 2015;157(6):1028-45.
Orloff, M. J., Hye, R. J., Wheeler, H. O., Isenberg, J. I., Haynes, K. S., Vaida, F., Girard, B., & Orloff, K. J. (2015). Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis. Surgery, 157(6), 1028-45. https://doi.org/10.1016/j.surg.2014.12.003
Orloff MJ, et al. Randomized Trials of Endoscopic Therapy and Transjugular Intrahepatic Portosystemic Shunt Versus Portacaval Shunt for Emergency and Elective Treatment of Bleeding Gastric Varices in Cirrhosis. Surgery. 2015;157(6):1028-45. PubMed PMID: 25957003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis. AU - Orloff,Marshall J, AU - Hye,Robert J, AU - Wheeler,Henry O, AU - Isenberg,Jon I, AU - Haynes,Kevin S, AU - Vaida,Florin, AU - Girard,Barbara, AU - Orloff,Karen J, PY - 2014/05/22/received PY - 2014/11/14/revised PY - 2014/12/03/accepted PY - 2015/5/10/entrez PY - 2015/5/10/pubmed PY - 2015/7/24/medline SP - 1028 EP - 45 JF - Surgery JO - Surgery VL - 157 IS - 6 N2 - IMPORTANCE: Bleeding esophageal varices has been studied extensively, but bleeding gastric varices (BGV) has received much less investigation. However, BGV has been reported in ≤ 30% of patients with acute variceal bleeding. In our studies of 1,836 bleeding cirrhotics, 12.7% were bleeding from gastric varices. BGV mortality rate of 45-55% has been reported. The BGV literature has mainly involved retrospective case reports, often with short-term follow-up. OBJECTIVE: We sought to describe the results of a prospective, randomized, controlled trial (RCT) in unselected, consecutive patients with BGV comparing endoscopic therapy (ET) with portacaval shunt (PCS; n = 518), and later comparing emergency transjugular intrahepatic portosystemic shunt (TIPS) with emergency portacaval shunt (EPCS; n = 70). DESIGN, SETTING, AND PARTICIPANTS: Initially, our RCT involved 518 patients with BGV comparing ET with direct PCS regarding control of bleeding, mortality rate, and disability. When entry of patients ended, the RCT was expanded to compare emergency TIPS with EPCS (n = 70). This RCT of BGV was separate from our other RCTs of bleeding esophageal varices. INTERVENTIONS: Initially, ET was compared with PCS. In the second part of our RCT, emergency TIPS was compared with emergency PCS (EPCS). MAIN OUTCOME MEASURES: Outcomes were survival, control of bleeding, portal-systemic encephalopathy (PSE), quality of life, and direct costs of care. In the RCT of ET versus PCS, 28 and 30%, respectively, were in Child class C. In the expanded RCT of TIPS versus EPCS, 40 and 41%, respectively, were in Child class C. Permanent control of BGV was achieved in 97-100% of patients treated by emergency or elective PCS, compared with 27-29% by ET. TIPS was even less effective, achieving long-term control of BGV in only 6%. Survival rates after PCS were greater at all time intervals and in all Child classes (P < .001). Repeated episodes of PSE occurred in 50% of TIPS patients, 16-17% treated by ET, and 8-11% treated by PCS. Shunt stenosis or occlusion occurred in 67% of TIPS patients, in contrast with 0-2% of PCS patients. CONCLUSION: These results support the conclusion that PCS is uniformly effective, whereas ET and TIPS are not very effective. SN - 1532-7361 UR - https://www.unboundmedicine.com/medline/citation/25957003/Randomized_trials_of_endoscopic_therapy_and_transjugular_intrahepatic_portosystemic_shunt_versus_portacaval_shunt_for_emergency_and_elective_treatment_of_bleeding_gastric_varices_in_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6060(14)00788-0 DB - PRIME DP - Unbound Medicine ER -