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Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data.
J Cyst Fibros. 2015 Sep; 14(5):668-77.JC

Abstract

BACKGROUND

The investigation of skeletal health data beyond dual X-ray absorptiometry (DXA) is limited in young individuals with CF. We assessed volumetric bone mineral densities (BMD), and bone and muscle parameters using peripheral quantitative computed tomography (pQCT) in individuals with CF and controls, 7.00-17.99 years.

METHODS

Peripheral QCT (XCT 3000, Stratec) measurements were made in 53 individuals with CF and 53 controls. Bone mineral content (BMC), total volumetric BMD (vBMD) and cross sectional area (CSA) of the bone were measured at the 4% and 66% sites of the non-dominant tibia and radius. Additionally, trabecular vBMD and bone strength index (BSIc) were measured at the 4% sites, and cortical vBMD, muscle CSA (mCSA) and strength strain index (SSI) were measured at the 66% sites.

RESULTS

Pre-pubertal males with CF had greater trabecular vBMD (p=0.01) and total vBMD (p=0.00) at 4% tibia, and greater total vBMD (p=0.02) at 4% radius. Pre-pubertal females with CF had greater total vBMD at 66% tibia (p=0.02) and radius (p=0.04), and cortical vBMD (p=0.04) at the radius. At puberty, the CF cohort had less BMC at 4% tibia (males, p=0.02; females, p=0.01), and smaller mCSA at 66% tibia (males, p=0.02; females, p=0.01). Pubertal CF females had a smaller bone CSA (p=0.01) at 4% tibia, and lower bone strength (SSI) at the tibia (p=0.00) and radius (p=0.05) sites.

CONCLUSIONS

Bone strength parameters were not compromised prior to puberty in this CF cohort. At puberty, the bone phenotype changed for this CF cohort, showing several deficits compared to the controls. However, bone strength was adapting to the mechanical demands of the muscle. Altered bone parameters and their implications for lowered bone strength with increased age may be greatly influenced by: the CF cohort remaining smaller for age and/or a reduced bone strain, secondary to reduced muscle force.

Authors+Show Affiliations

The University of Queensland, Queensland Children's Medical Research Institute, Children's Nutrition Research Centre, Brisbane, Australia; The University of Queensland, School of Medicine, Brisbane, Australia. Electronic address: d.brookes@uqconnect.edu.au.The Children's Hospital at Westmead, Sydney, Australia.The Children's Hospital at Westmead, Sydney, Australia; University of Sydney, School of Medicine, Sydney, Australia.The University of Queensland, Queensland Children's Medical Research Institute, Children's Nutrition Research Centre, Brisbane, Australia; The University of Queensland, School of Medicine, Brisbane, Australia.The University of Queensland, Queensland Children's Medical Research Institute, Children's Nutrition Research Centre, Brisbane, Australia; The University of Queensland, School of Medicine, Brisbane, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25957706

Citation

Brookes, Denise S K., et al. "Cystic Fibrosis-related Bone Disease in Children: Examination of Peripheral Quantitative Computed Tomography (pQCT) Data." Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, vol. 14, no. 5, 2015, pp. 668-77.
Brookes DS, Briody JN, Munns CF, et al. Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data. J Cyst Fibros. 2015;14(5):668-77.
Brookes, D. S., Briody, J. N., Munns, C. F., Davies, P. S., & Hill, R. J. (2015). Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 14(5), 668-77. https://doi.org/10.1016/j.jcf.2015.04.005
Brookes DS, et al. Cystic Fibrosis-related Bone Disease in Children: Examination of Peripheral Quantitative Computed Tomography (pQCT) Data. J Cyst Fibros. 2015;14(5):668-77. PubMed PMID: 25957706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data. AU - Brookes,Denise S K, AU - Briody,Julie N, AU - Munns,Craig F, AU - Davies,Peter S W, AU - Hill,Rebecca J, Y1 - 2015/05/06/ PY - 2014/09/18/received PY - 2015/04/02/revised PY - 2015/04/20/accepted PY - 2015/5/11/entrez PY - 2015/5/11/pubmed PY - 2016/6/9/medline KW - Bone KW - Bone strength KW - Cystic fibrosis KW - Muscle KW - Volumetric bone mineral density KW - pQCT SP - 668 EP - 77 JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JO - J Cyst Fibros VL - 14 IS - 5 N2 - BACKGROUND: The investigation of skeletal health data beyond dual X-ray absorptiometry (DXA) is limited in young individuals with CF. We assessed volumetric bone mineral densities (BMD), and bone and muscle parameters using peripheral quantitative computed tomography (pQCT) in individuals with CF and controls, 7.00-17.99 years. METHODS: Peripheral QCT (XCT 3000, Stratec) measurements were made in 53 individuals with CF and 53 controls. Bone mineral content (BMC), total volumetric BMD (vBMD) and cross sectional area (CSA) of the bone were measured at the 4% and 66% sites of the non-dominant tibia and radius. Additionally, trabecular vBMD and bone strength index (BSIc) were measured at the 4% sites, and cortical vBMD, muscle CSA (mCSA) and strength strain index (SSI) were measured at the 66% sites. RESULTS: Pre-pubertal males with CF had greater trabecular vBMD (p=0.01) and total vBMD (p=0.00) at 4% tibia, and greater total vBMD (p=0.02) at 4% radius. Pre-pubertal females with CF had greater total vBMD at 66% tibia (p=0.02) and radius (p=0.04), and cortical vBMD (p=0.04) at the radius. At puberty, the CF cohort had less BMC at 4% tibia (males, p=0.02; females, p=0.01), and smaller mCSA at 66% tibia (males, p=0.02; females, p=0.01). Pubertal CF females had a smaller bone CSA (p=0.01) at 4% tibia, and lower bone strength (SSI) at the tibia (p=0.00) and radius (p=0.05) sites. CONCLUSIONS: Bone strength parameters were not compromised prior to puberty in this CF cohort. At puberty, the bone phenotype changed for this CF cohort, showing several deficits compared to the controls. However, bone strength was adapting to the mechanical demands of the muscle. Altered bone parameters and their implications for lowered bone strength with increased age may be greatly influenced by: the CF cohort remaining smaller for age and/or a reduced bone strain, secondary to reduced muscle force. SN - 1873-5010 UR - https://www.unboundmedicine.com/medline/citation/25957706/Cystic_fibrosis_related_bone_disease_in_children:_Examination_of_peripheral_quantitative_computed_tomography__pQCT__data_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-1993(15)00107-1 DB - PRIME DP - Unbound Medicine ER -