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The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation.
Res Vet Sci. 2015 Jun; 100:189-96.RV

Abstract

Providing a pre-operative prognosis for dogs presented with absent deep pain perception (DPP) is extremely challenging, as the overall recovery rates widely vary. This study assesses the possible correlation between the severity of spinal cord injury and CSF cytology in 31 paraplegic dogs presented with absent DPP due to acute thoracolumbar intervertebral disc herniation (TL-IVDH). All dogs underwent surgical decompression immediately following diagnosis. CSF TNCC, macrophage percentage and macrophage to monocyte (MΦ:M) ratio were significantly higher in dogs that failed to regain DPP within 10 days post-operatively and in dogs that failed to regain ambulation at the end of the study period (P< 0.05). MΦ:M of 0.73 and higher corresponded to a sensitivity of 54% and specificity of 100% for prediction of a negative long-term outcome. CSF TNCC, macrophage percentage and MΦ:M ratio effectively predicted regaining DPP and the long-term outcome in dogs that lost DPP due to acute TL-IVDH.

Authors+Show Affiliations

Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Department of Small Animal Internal Medicine, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Department of Small Animal Internal Medicine, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Teaching Services Unit, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel.Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel. Electronic address: merav.shamir@mail.huji.ac.il.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25957960

Citation

Chamisha, Y, et al. "The Prognostic Value of Cerebrospinal Fluid Characteristics in Dogs Without Deep Pain Perception Due to Thoracolumbar Disc Herniation." Research in Veterinary Science, vol. 100, 2015, pp. 189-96.
Chamisha Y, Aroch I, Kuzi S, et al. The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation. Res Vet Sci. 2015;100:189-96.
Chamisha, Y., Aroch, I., Kuzi, S., Srugo, I., Bdolah-Abram, T., Chai, O., Christopher, M. M., Merbl, Y., Rothwell, K., & Shamir, M. H. (2015). The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation. Research in Veterinary Science, 100, 189-96. https://doi.org/10.1016/j.rvsc.2015.03.017
Chamisha Y, et al. The Prognostic Value of Cerebrospinal Fluid Characteristics in Dogs Without Deep Pain Perception Due to Thoracolumbar Disc Herniation. Res Vet Sci. 2015;100:189-96. PubMed PMID: 25957960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation. AU - Chamisha,Y, AU - Aroch,I, AU - Kuzi,S, AU - Srugo,I, AU - Bdolah-Abram,T, AU - Chai,O, AU - Christopher,M M, AU - Merbl,Y, AU - Rothwell,K, AU - Shamir,M H, Y1 - 2015/04/08/ PY - 2014/11/12/received PY - 2015/02/03/revised PY - 2015/03/14/accepted PY - 2015/5/11/entrez PY - 2015/5/11/pubmed PY - 2016/2/18/medline KW - CSF KW - Deep pain perception KW - Dog KW - Intervertebral disc herniation KW - Prognosis SP - 189 EP - 96 JF - Research in veterinary science JO - Res. Vet. Sci. VL - 100 N2 - Providing a pre-operative prognosis for dogs presented with absent deep pain perception (DPP) is extremely challenging, as the overall recovery rates widely vary. This study assesses the possible correlation between the severity of spinal cord injury and CSF cytology in 31 paraplegic dogs presented with absent DPP due to acute thoracolumbar intervertebral disc herniation (TL-IVDH). All dogs underwent surgical decompression immediately following diagnosis. CSF TNCC, macrophage percentage and macrophage to monocyte (MΦ:M) ratio were significantly higher in dogs that failed to regain DPP within 10 days post-operatively and in dogs that failed to regain ambulation at the end of the study period (P< 0.05). MΦ:M of 0.73 and higher corresponded to a sensitivity of 54% and specificity of 100% for prediction of a negative long-term outcome. CSF TNCC, macrophage percentage and MΦ:M ratio effectively predicted regaining DPP and the long-term outcome in dogs that lost DPP due to acute TL-IVDH. SN - 1532-2661 UR - https://www.unboundmedicine.com/medline/citation/25957960/The_prognostic_value_of_cerebrospinal_fluid_characteristics_in_dogs_without_deep_pain_perception_due_to_thoracolumbar_disc_herniation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(15)00091-0 DB - PRIME DP - Unbound Medicine ER -