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Prevalence of celiac disease in Indian patients with irritable bowel syndrome and uninvestigated dyspepsia.
J Dig Dis 2015; 16(8):443-8JD

Abstract

OBJECTIVE

The clinical spectrum of celiac disease (CeD) is wide and its symptoms overlap with those of functional bowel diseases. This study aimed to investigate the relationship among gluten-related disorders, irritable bowel syndrome (IBS) and uninvestigated dyspepsia in Indian patients.

METHODS

Patients with IBS and uninvestigated dyspepsia (using Rome III criteria) were tested for immunoglobulin A (IgA) anti-tissue transglutaminase (anti-tTG) antibody and anti-gliadin antibody (AGA). Those with positive anti-tTG antibody were evaluated for the presence of villous abnormalities. Patients who were only IgA AGA-positive were considered to have gluten sensitivity and those with positive anti-tTG antibody and villous atrophy were considered to have CeD.

RESULTS

Of 362 patients with IBS, 22 (6.1%) had positive anti-tTG antibody, among whom 3 (0.8%) had CeD and 19 had potential CeD. Of 358 patients with uninvestigated dyspepsia, 18 (5.0%) were anti-tTG antibody-positive and among them 4 (1.1%) had CeD and 14 had potential CeD. AGA was positive in 104 (28.7%) patients with IBS and 68 (19.0%) with uninvestigated dyspepsia, suggesting the presence of gluten sensitivity.

CONCLUSION

This study highlights the relationship between IBS or dyspepsia and CeD or gluten sensitivity.

Authors+Show Affiliations

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.Pathology, All India Institute of Medical Sciences, New Delhi, India.Pathology, All India Institute of Medical Sciences, New Delhi, India.Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25959064

Citation

Sharma, Hanish, et al. "Prevalence of Celiac Disease in Indian Patients With Irritable Bowel Syndrome and Uninvestigated Dyspepsia." Journal of Digestive Diseases, vol. 16, no. 8, 2015, pp. 443-8.
Sharma H, Verma AK, Das P, et al. Prevalence of celiac disease in Indian patients with irritable bowel syndrome and uninvestigated dyspepsia. J Dig Dis. 2015;16(8):443-8.
Sharma, H., Verma, A. K., Das, P., Dattagupta, S., Ahuja, V., & Makharia, G. K. (2015). Prevalence of celiac disease in Indian patients with irritable bowel syndrome and uninvestigated dyspepsia. Journal of Digestive Diseases, 16(8), pp. 443-8. doi:10.1111/1751-2980.12260.
Sharma H, et al. Prevalence of Celiac Disease in Indian Patients With Irritable Bowel Syndrome and Uninvestigated Dyspepsia. J Dig Dis. 2015;16(8):443-8. PubMed PMID: 25959064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of celiac disease in Indian patients with irritable bowel syndrome and uninvestigated dyspepsia. AU - Sharma,Hanish, AU - Verma,Anil K, AU - Das,Prasenjit, AU - Dattagupta,Siddhartha, AU - Ahuja,Vineet, AU - Makharia,Govind K, PY - 2015/5/12/entrez PY - 2015/5/12/pubmed PY - 2016/5/28/medline KW - celiac disease KW - dyspepsia KW - irritable bowel syndrome KW - non-celiac gluten sensitivity SP - 443 EP - 8 JF - Journal of digestive diseases JO - J Dig Dis VL - 16 IS - 8 N2 - OBJECTIVE: The clinical spectrum of celiac disease (CeD) is wide and its symptoms overlap with those of functional bowel diseases. This study aimed to investigate the relationship among gluten-related disorders, irritable bowel syndrome (IBS) and uninvestigated dyspepsia in Indian patients. METHODS: Patients with IBS and uninvestigated dyspepsia (using Rome III criteria) were tested for immunoglobulin A (IgA) anti-tissue transglutaminase (anti-tTG) antibody and anti-gliadin antibody (AGA). Those with positive anti-tTG antibody were evaluated for the presence of villous abnormalities. Patients who were only IgA AGA-positive were considered to have gluten sensitivity and those with positive anti-tTG antibody and villous atrophy were considered to have CeD. RESULTS: Of 362 patients with IBS, 22 (6.1%) had positive anti-tTG antibody, among whom 3 (0.8%) had CeD and 19 had potential CeD. Of 358 patients with uninvestigated dyspepsia, 18 (5.0%) were anti-tTG antibody-positive and among them 4 (1.1%) had CeD and 14 had potential CeD. AGA was positive in 104 (28.7%) patients with IBS and 68 (19.0%) with uninvestigated dyspepsia, suggesting the presence of gluten sensitivity. CONCLUSION: This study highlights the relationship between IBS or dyspepsia and CeD or gluten sensitivity. SN - 1751-2980 UR - https://www.unboundmedicine.com/medline/citation/25959064/Prevalence_of_celiac_disease_in_Indian_patients_with_irritable_bowel_syndrome_and_uninvestigated_dyspepsia_ L2 - https://doi.org/10.1111/1751-2980.12260 DB - PRIME DP - Unbound Medicine ER -