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A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report.

Abstract

INTRODUCTION

Human infection with avian influenza A (H7N9) virus was first reported on March, 2013 in the Yangtze River Delta region of China. The majority of human cases were detected in mainland China; other regions out of mainland China reported imported human cases, including Hong Kong SAR, Taiwan (the Republic of China) and Malaysia, due to human transportation. Here, we report the first human case of H7N9 infection imported into Guizhou Province during the Spring Festival travel season in January 2014.

CASE PRESENTATION

In early January 2014, a 38-year-old healthy Chinese man, a migrant worker returning from previously H7N9-affected Zhejiang Province, was identified as the first human case of infection with avian influenza A(H7N9) virus in Guizhou Province. He developed fever in Zhejiang at the beginning of January 2014, and returned to Guizhou for the Chinese New Year the next day. He went to seek medical care, but deteriorated rapidly and died on day 8 after his illness onset. The influenza virus A/Guizhou/01502/2014 isolated from the patient had 99% identity with viruses circulating in the Yangtze River Delta region. Selected amino acids substitutions, well-known to be associated with mammalian adaptation, viral replication and drug resistance were similar to other H7N9 viruses circulating in humans.

CONCLUSIONS

Epidemiology investigation and laboratory results confirmed it was the first imported case of H7N9 infection in Guizhou Province. This finding further indicated that more human H7N9 cases may be detected in other regions due to frequent travel both domestically and internationally.

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  • Authors+Show Affiliations

    ,

    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. wangdingm123@sina.com.

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    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. tgp@gzcdc.gov.cn.

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    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. cdchuangyan@163.com.

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    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. cdccfs@gzcdc.gov.cn.

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    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. zjumedjun@163.com.

    ,

    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. zl52429@126.com.

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    Guizhou Provincial Center for Disease Control and Prevention, 101 Bageyan Road, Guiyang City, 550004, Guizhou Province, China. cdc_cfsjyk@gzcdc.gov.cn.

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    Zunyi Prefecture Center for Disease Control and Prevention, 19 Xima Road, Zunyi City, 563002, Guizhou Province, China. zycdc@gzcdc.gov.cn.

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    Meitan County Center for Disease Control and Prevention, 99-8 Zhedanan Road, Meitan County, 564100, Guizhou Province, China. zy_mtx@gzcdc.gov.cn.

    ,

    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing, 102206, P. R China. lixiyan@cnic.org.cn.

    ,

    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing, 102206, P. R China. yanglei@cnic.org.cn.

    ,

    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing, 102206, P. R China. lanyu@cnic.org.cn.

    ,

    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing, 102206, P. R China. baitian@cnic.org.cn.

    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing, 102206, P. R China. yshu@cnic.org.cn.

    Source

    Journal of medical case reports 9: 2015 May 12 pg 109

    MeSH

    Adult
    China
    Communicable Diseases, Emerging
    Fatal Outcome
    Fever
    Humans
    Influenza A Virus, H7N9 Subtype
    Influenza, Human
    Male
    Phylogeny
    Transients and Migrants

    Pub Type(s)

    Case Reports
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25962780

    Citation

    Wang, Dingming, et al. "A Returning Migrant Worker With Avian Influenza a (H7N9) Virus Infection in Guizhou, China: a Case Report." Journal of Medical Case Reports, vol. 9, 2015, p. 109.
    Wang D, Tang G, Huang Y, et al. A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report. J Med Case Rep. 2015;9:109.
    Wang, D., Tang, G., Huang, Y., Yu, C., Li, S., Zhuang, L., ... Shu, Y. (2015). A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report. Journal of Medical Case Reports, 9, p. 109. doi:10.1186/s13256-015-0580-1.
    Wang D, et al. A Returning Migrant Worker With Avian Influenza a (H7N9) Virus Infection in Guizhou, China: a Case Report. J Med Case Rep. 2015 May 12;9:109. PubMed PMID: 25962780.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report. AU - Wang,Dingming, AU - Tang,Guangpeng, AU - Huang,Yan, AU - Yu,Chun, AU - Li,Shijun, AU - Zhuang,Li, AU - Fu,Lin, AU - Wang,Shiping, AU - Li,Nanshi, AU - Li,Xiyan, AU - Yang,Lei, AU - Lan,Yu, AU - Bai,Tian, AU - Shu,Yuelong, Y1 - 2015/05/12/ PY - 2014/09/20/received PY - 2015/03/26/accepted PY - 2015/5/13/entrez PY - 2015/5/13/pubmed PY - 2015/12/19/medline SP - 109 EP - 109 JF - Journal of medical case reports JO - J Med Case Rep VL - 9 N2 - INTRODUCTION: Human infection with avian influenza A (H7N9) virus was first reported on March, 2013 in the Yangtze River Delta region of China. The majority of human cases were detected in mainland China; other regions out of mainland China reported imported human cases, including Hong Kong SAR, Taiwan (the Republic of China) and Malaysia, due to human transportation. Here, we report the first human case of H7N9 infection imported into Guizhou Province during the Spring Festival travel season in January 2014. CASE PRESENTATION: In early January 2014, a 38-year-old healthy Chinese man, a migrant worker returning from previously H7N9-affected Zhejiang Province, was identified as the first human case of infection with avian influenza A(H7N9) virus in Guizhou Province. He developed fever in Zhejiang at the beginning of January 2014, and returned to Guizhou for the Chinese New Year the next day. He went to seek medical care, but deteriorated rapidly and died on day 8 after his illness onset. The influenza virus A/Guizhou/01502/2014 isolated from the patient had 99% identity with viruses circulating in the Yangtze River Delta region. Selected amino acids substitutions, well-known to be associated with mammalian adaptation, viral replication and drug resistance were similar to other H7N9 viruses circulating in humans. CONCLUSIONS: Epidemiology investigation and laboratory results confirmed it was the first imported case of H7N9 infection in Guizhou Province. This finding further indicated that more human H7N9 cases may be detected in other regions due to frequent travel both domestically and internationally. SN - 1752-1947 UR - https://www.unboundmedicine.com/medline/citation/25962780/A_returning_migrant_worker_with_avian_influenza_A__H7N9__virus_infection_in_Guizhou_China:_a_case_report_ L2 - https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-015-0580-1 DB - PRIME DP - Unbound Medicine ER -