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Comparison between breast MRI and contrast-enhanced spectral mammography.
Med Sci Monit. 2015 May 12; 21:1358-67.MS

Abstract

BACKGROUND

The main goal of this study was to compare contrast-enhanced spectral mammography (CESM) and breast magnetic resonance imaging (MRI) with histopathological results and to compare the sensitivity, accuracy, and positive and negative predictive values for both imaging modalities.

MATERIAL/METHODS

After ethics approval, CESM and MRI examinations were performed in 102 patients who had suspicious lesions described in conventional mammography. All visible lesions were evaluated independently by 2 experienced radiologists using BI-RADS classifications (scale 1-5). Dimensions of lesions measured with each modality were compared to postoperative histopathology results.

RESULTS

There were 102 patients entered into CESM/MRI studies and 118 lesions were identified by the combination of CESM and breast MRI. Histopathology confirmed that 81 of 118 lesions were malignant and 37 were benign. Of the 81 malignant lesions, 72 were invasive cancers and 9 were in situ cancers. Sensitivity was 100% with CESM and 93% with breast MRI. Accuracy was 79% with CESM and 73% with breast MRI. ROC curve areas based on BI-RADS were 0.83 for CESM and 0.84 for breast MRI. Lesion size estimates on CESM and breast MRI were similar, both slightly larger than those from histopathology.

CONCLUSIONS

Our results indicate that CESM has the potential to be a valuable diagnostic method that enables accurate detection of malignant breast lesions, has high negative predictive value, and a false-positive rate similar to that of breast MRI.

Authors+Show Affiliations

Department of Radiology, Cancer Centre and Institute of Oncology, Cracow, Poland.Department of Radiology, Cancer Centre and Institute of Oncology, Cracow, Poland.Department of Radiology, University of Colorado - Denver, School of Medicine, Aurora, CO, USA.Department of Radiology, Cancer Centre and Institute of Oncology, Cracow, Poland.Department of Pathology, Cancer Centre and Institute of Oncology, Cracow, Poland.Department of Surgical Oncology, Cancer Centre and Institute of Oncology, Cracow, Poland.Department of Oncological Gyneacology, Cancer Centre and Institute of Oncology, Cracow, Poland.Department of Radioteraphy, Cancer Centre and Institute of Oncology, Cracow, Poland.

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25963880

Citation

Łuczyńska, Elżbieta, et al. "Comparison Between Breast MRI and Contrast-enhanced Spectral Mammography." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 21, 2015, pp. 1358-67.
Łuczyńska E, Heinze-Paluchowska S, Hendrick E, et al. Comparison between breast MRI and contrast-enhanced spectral mammography. Med Sci Monit. 2015;21:1358-67.
Łuczyńska, E., Heinze-Paluchowska, S., Hendrick, E., Dyczek, S., Ryś, J., Herman, K., Blecharz, P., & Jakubowicz, J. (2015). Comparison between breast MRI and contrast-enhanced spectral mammography. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 1358-67. https://doi.org/10.12659/MSM.893018
Łuczyńska E, et al. Comparison Between Breast MRI and Contrast-enhanced Spectral Mammography. Med Sci Monit. 2015 May 12;21:1358-67. PubMed PMID: 25963880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between breast MRI and contrast-enhanced spectral mammography. AU - Łuczyńska,Elżbieta, AU - Heinze-Paluchowska,Sylwia, AU - Hendrick,Edward, AU - Dyczek,Sonia, AU - Ryś,Janusz, AU - Herman,Krzysztof, AU - Blecharz,Paweł, AU - Jakubowicz,Jerzy, Y1 - 2015/05/12/ PY - 2015/5/13/entrez PY - 2015/5/13/pubmed PY - 2015/12/29/medline SP - 1358 EP - 67 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 21 N2 - BACKGROUND: The main goal of this study was to compare contrast-enhanced spectral mammography (CESM) and breast magnetic resonance imaging (MRI) with histopathological results and to compare the sensitivity, accuracy, and positive and negative predictive values for both imaging modalities. MATERIAL/METHODS: After ethics approval, CESM and MRI examinations were performed in 102 patients who had suspicious lesions described in conventional mammography. All visible lesions were evaluated independently by 2 experienced radiologists using BI-RADS classifications (scale 1-5). Dimensions of lesions measured with each modality were compared to postoperative histopathology results. RESULTS: There were 102 patients entered into CESM/MRI studies and 118 lesions were identified by the combination of CESM and breast MRI. Histopathology confirmed that 81 of 118 lesions were malignant and 37 were benign. Of the 81 malignant lesions, 72 were invasive cancers and 9 were in situ cancers. Sensitivity was 100% with CESM and 93% with breast MRI. Accuracy was 79% with CESM and 73% with breast MRI. ROC curve areas based on BI-RADS were 0.83 for CESM and 0.84 for breast MRI. Lesion size estimates on CESM and breast MRI were similar, both slightly larger than those from histopathology. CONCLUSIONS: Our results indicate that CESM has the potential to be a valuable diagnostic method that enables accurate detection of malignant breast lesions, has high negative predictive value, and a false-positive rate similar to that of breast MRI. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/25963880/Comparison_between_breast_MRI_and_contrast_enhanced_spectral_mammography_ L2 - https://www.medscimonit.com/download/index/idArt/893018 DB - PRIME DP - Unbound Medicine ER -