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Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs.
World J Virol 2015; 4(2):56-77WJ

Abstract

For human immunodeficiency virus (HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy (HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results.

Authors+Show Affiliations

Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Sérgio Paulo Bydlowski, Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo Medical School (FMUSP), São Paulo SP 05403-000, Brazil.Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Sérgio Paulo Bydlowski, Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo Medical School (FMUSP), São Paulo SP 05403-000, Brazil.Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Sérgio Paulo Bydlowski, Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo Medical School (FMUSP), São Paulo SP 05403-000, Brazil.Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Sérgio Paulo Bydlowski, Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo Medical School (FMUSP), São Paulo SP 05403-000, Brazil.Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Sérgio Paulo Bydlowski, Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo Medical School (FMUSP), São Paulo SP 05403-000, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25964872

Citation

da Cunha, Joel, et al. "Impact of Antiretroviral Therapy On Lipid Metabolism of Human Immunodeficiency Virus-infected Patients: Old and New Drugs." World Journal of Virology, vol. 4, no. 2, 2015, pp. 56-77.
da Cunha J, Maselli LM, Stern AC, et al. Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs. World J Virol. 2015;4(2):56-77.
da Cunha, J., Maselli, L. M., Stern, A. C., Spada, C., & Bydlowski, S. P. (2015). Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs. World Journal of Virology, 4(2), pp. 56-77. doi:10.5501/wjv.v4.i2.56.
da Cunha J, et al. Impact of Antiretroviral Therapy On Lipid Metabolism of Human Immunodeficiency Virus-infected Patients: Old and New Drugs. World J Virol. 2015 May 12;4(2):56-77. PubMed PMID: 25964872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs. AU - da Cunha,Joel, AU - Maselli,Luciana Morganti Ferreira, AU - Stern,Ana Carolina Bassi, AU - Spada,Celso, AU - Bydlowski,Sérgio Paulo, PY - 2014/10/27/received PY - 2015/02/09/revised PY - 2015/03/05/accepted PY - 2015/5/13/entrez PY - 2015/5/13/pubmed PY - 2015/5/13/medline KW - Atherosclerosis KW - Diet KW - Dyslipidemia KW - Fibrates KW - Highly active antiretroviral therapy KW - Human immunodeficiency virus-1 infection KW - Lifestyle KW - Lipodystrophy KW - Protease inhibitors KW - Statins SP - 56 EP - 77 JF - World journal of virology JO - World J Virol VL - 4 IS - 2 N2 - For human immunodeficiency virus (HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy (HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results. SN - 2220-3249 UR - https://www.unboundmedicine.com/medline/citation/25964872/Impact_of_antiretroviral_therapy_on_lipid_metabolism_of_human_immunodeficiency_virus_infected_patients:_Old_and_new_drugs_ L2 - http://www.wjgnet.com/2220-3249/full/v4/i2/56.htm DB - PRIME DP - Unbound Medicine ER -