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Vitamin D and lung cancer risk: a comprehensive review and meta-analysis.
Cell Physiol Biochem 2015; 36(1):299-305CP

Abstract

BACKGROUND/AIM

Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available.

METHODS

To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk.

RESULTS

Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184).

CONCLUSION

Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer.

Authors+Show Affiliations

Department of Respiratory Diseases, Beijing Military Region General Hospital of PLA, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

25967968

Citation

Zhang, Liqun, et al. "Vitamin D and Lung Cancer Risk: a Comprehensive Review and Meta-analysis." Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, vol. 36, no. 1, 2015, pp. 299-305.
Zhang L, Wang S, Che X, et al. Vitamin D and lung cancer risk: a comprehensive review and meta-analysis. Cell Physiol Biochem. 2015;36(1):299-305.
Zhang, L., Wang, S., Che, X., & Li, X. (2015). Vitamin D and lung cancer risk: a comprehensive review and meta-analysis. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 36(1), pp. 299-305. doi:10.1159/000374072.
Zhang L, et al. Vitamin D and Lung Cancer Risk: a Comprehensive Review and Meta-analysis. Cell Physiol Biochem. 2015;36(1):299-305. PubMed PMID: 25967968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and lung cancer risk: a comprehensive review and meta-analysis. AU - Zhang,Liqun, AU - Wang,Sihai, AU - Che,Xiaoyu, AU - Li,Xuehui, Y1 - 2015/05/04/ PY - 2015/02/09/accepted PY - 2015/5/14/entrez PY - 2015/5/15/pubmed PY - 2016/2/10/medline SP - 299 EP - 305 JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology JO - Cell. Physiol. Biochem. VL - 36 IS - 1 N2 - BACKGROUND/AIM: Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available. METHODS: To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk. RESULTS: Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184). CONCLUSION: Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer. SN - 1421-9778 UR - https://www.unboundmedicine.com/medline/citation/25967968/full_citation L2 - https://www.karger.com?DOI=10.1159/000374072 DB - PRIME DP - Unbound Medicine ER -