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In vivo visualization of hair follicles by ultrasound biomicroscopy in alopecia areata and its correlation with histopathology.
Acta Dermatovenerol Croat. 2015; 23(1):12-8.AD

Abstract

Ultrasound biomicroscopy (UBM) is a non-invasive imaging technique used in examination of several skin diseases but never in imaging hair and scalp diseases. Main objective of this investigation was assessment of the efficacy of UBM for in vivo visualization of hair follicles in cases of alopecia areata (AA) and correlation of findings with histopathological findings. This study included 30 patients with AA. Two areas, one with AA and a control area, were marked, examined by UBM and then biopsied for histopathological examination. In patients with alopecia totalis (AT) or universalis (AU) only an AA area was examined. Non-echogenic conical shadows reaching the epidermal entrance echo (probably corresponding to the hair follicles) were seen and were wider and fewer in number in areas of AA than in normal control areas. No significant difference was found regarding number and width of hair follicles between UBM and histopathological examination. However, a significant increase in length of follicles in histopathology was detected, indicating that the UBM image was probably unable to reach the deepest part of the follicle. Main limitation of the study is small number of cases. No significant difference was found between UBM and histological measurements of hair follicle number and width in patients with AA, making UBM a useful tool for in vivo visualization of hair follicles.

Authors+Show Affiliations

El-Zawahry BM
No affiliation info available
El Hanafy M
No affiliation info available
Bassiouny DA
Dalia Ahmed Bassiouny, MD, 51 B Damascus Street, Mohandessien, Cairo, Egypt; daliabas73@yahoo.com.
Fawzy MM
No affiliation info available
Abdel-Mageed Badawy M
No affiliation info available
El-Khateeb EM
No affiliation info available

MeSH

AdolescentAdultAlopecia AreataCase-Control StudiesFemaleHair FollicleHumansMaleMicroscopy, AcousticMiddle AgedYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25969907

Citation

El-Zawahry, Bakr Mohamed, et al. "In Vivo Visualization of Hair Follicles By Ultrasound Biomicroscopy in Alopecia Areata and Its Correlation With Histopathology." Acta Dermatovenerologica Croatica : ADC, vol. 23, no. 1, 2015, pp. 12-8.
El-Zawahry BM, El Hanafy M, Bassiouny DA, et al. In vivo visualization of hair follicles by ultrasound biomicroscopy in alopecia areata and its correlation with histopathology. Acta Dermatovenerol Croat. 2015;23(1):12-8.
El-Zawahry, B. M., El Hanafy, M., Bassiouny, D. A., Fawzy, M. M., Abdel-Mageed Badawy, M., & El-Khateeb, E. M. (2015). In vivo visualization of hair follicles by ultrasound biomicroscopy in alopecia areata and its correlation with histopathology. Acta Dermatovenerologica Croatica : ADC, 23(1), 12-8.
El-Zawahry BM, et al. In Vivo Visualization of Hair Follicles By Ultrasound Biomicroscopy in Alopecia Areata and Its Correlation With Histopathology. Acta Dermatovenerol Croat. 2015;23(1):12-8. PubMed PMID: 25969907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo visualization of hair follicles by ultrasound biomicroscopy in alopecia areata and its correlation with histopathology. AU - El-Zawahry,Bakr Mohamed, AU - El Hanafy,Mervat, AU - Bassiouny,Dalia Ahmed, AU - Fawzy,Marwa Mohamed, AU - Abdel-Mageed Badawy,Manal, AU - El-Khateeb,Eman Mohamed, PY - 2015/5/14/entrez PY - 2015/5/15/pubmed PY - 2016/12/15/medline SP - 12 EP - 8 JF - Acta dermatovenerologica Croatica : ADC JO - Acta Dermatovenerol Croat VL - 23 IS - 1 N2 - Ultrasound biomicroscopy (UBM) is a non-invasive imaging technique used in examination of several skin diseases but never in imaging hair and scalp diseases. Main objective of this investigation was assessment of the efficacy of UBM for in vivo visualization of hair follicles in cases of alopecia areata (AA) and correlation of findings with histopathological findings. This study included 30 patients with AA. Two areas, one with AA and a control area, were marked, examined by UBM and then biopsied for histopathological examination. In patients with alopecia totalis (AT) or universalis (AU) only an AA area was examined. Non-echogenic conical shadows reaching the epidermal entrance echo (probably corresponding to the hair follicles) were seen and were wider and fewer in number in areas of AA than in normal control areas. No significant difference was found regarding number and width of hair follicles between UBM and histopathological examination. However, a significant increase in length of follicles in histopathology was detected, indicating that the UBM image was probably unable to reach the deepest part of the follicle. Main limitation of the study is small number of cases. No significant difference was found between UBM and histological measurements of hair follicle number and width in patients with AA, making UBM a useful tool for in vivo visualization of hair follicles. SN - 1847-6538 UR - https://www.unboundmedicine.com/medline/citation/25969907/In_vivo_visualization_of_hair_follicles_by_ultrasound_biomicroscopy_in_alopecia_areata_and_its_correlation_with_histopathology_ DB - PRIME DP - Unbound Medicine ER -