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Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus.
Nutr J 2015; 14:14NJ

Abstract

AIMS

Chromium (Cr) is a trace element involved in glucose homeostasis. We aim to evaluate and quantify the effects of Cr supplementation on A1C and FPG in patients with T2DM.

MATERIALS AND METHODS

A systematic literature search of Pubmed, EMBASE and the Cochrane Library (from database inception to 11/2014) with no language restrictions sought RCTs or cohort studies evaluating Cr supplementation in T2DM vs control and reporting either change in glycated hemoglobin (A1C) or fasting plasma glucose (FPG). Meta-analysis was conducted on each subtype of Cr supplement separately, and was analyzed by random effects model to yield the weighted mean differences (WMD) and 95% confidence intervals (CIs). Heterogeneity was assessed by using the I(2) statistic.

RESULTS

A total of 14 RCTs (n=875 participants, mean age range: 30 to 83 years old, 8 to 24 weeks of follow-up) were identified (Cr chloride: n=3 study, Cr picolinate: n=5 study, brewer's yeast: n=4 study and Cr yeast: n=3 study). Compared with placebo, Cr yeast, brewer's yeast and Cr picolinate did not show statistically significant effects on A1C. Furthermore, compared to control, Cr chloride, Cr yeast and Cr picolinate showed no effect on FPG, however, brewer's yeast showed a statistically significant decrease in FPG -19.23 mg/dL (95% CI=-35.30 to -3.16, I(2)=21%, n=137).

CONCLUSIONS

Cr supplementation with brewer's yeast may provide marginal benefits in lowering FPG in patients with T2DM compared to placebo however it did not have any effect on A1C.

Authors+Show Affiliations

Western University of Health Sciences, College of Pharmacy, 309 E. Second St, Pomona, CA, 91766, USA. ryin@westernu.edu.Western University of Health Sciences, College of Pharmacy, 309 E. Second St, Pomona, CA, 91766, USA. ophung@westernu.edu.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

25971249

Citation

Yin, Raynold V., and Olivia J. Phung. "Effect of Chromium Supplementation On Glycated Hemoglobin and Fasting Plasma Glucose in Patients With Diabetes Mellitus." Nutrition Journal, vol. 14, 2015, p. 14.
Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015;14:14.
Yin, R. V., & Phung, O. J. (2015). Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutrition Journal, 14, p. 14. doi:10.1186/1475-2891-14-14.
Yin RV, Phung OJ. Effect of Chromium Supplementation On Glycated Hemoglobin and Fasting Plasma Glucose in Patients With Diabetes Mellitus. Nutr J. 2015 Feb 13;14:14. PubMed PMID: 25971249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. AU - Yin,Raynold V, AU - Phung,Olivia J, Y1 - 2015/02/13/ PY - 2014/08/27/received PY - 2015/01/12/accepted PY - 2015/5/15/entrez PY - 2015/5/15/pubmed PY - 2016/1/20/medline SP - 14 EP - 14 JF - Nutrition journal JO - Nutr J VL - 14 N2 - AIMS: Chromium (Cr) is a trace element involved in glucose homeostasis. We aim to evaluate and quantify the effects of Cr supplementation on A1C and FPG in patients with T2DM. MATERIALS AND METHODS: A systematic literature search of Pubmed, EMBASE and the Cochrane Library (from database inception to 11/2014) with no language restrictions sought RCTs or cohort studies evaluating Cr supplementation in T2DM vs control and reporting either change in glycated hemoglobin (A1C) or fasting plasma glucose (FPG). Meta-analysis was conducted on each subtype of Cr supplement separately, and was analyzed by random effects model to yield the weighted mean differences (WMD) and 95% confidence intervals (CIs). Heterogeneity was assessed by using the I(2) statistic. RESULTS: A total of 14 RCTs (n=875 participants, mean age range: 30 to 83 years old, 8 to 24 weeks of follow-up) were identified (Cr chloride: n=3 study, Cr picolinate: n=5 study, brewer's yeast: n=4 study and Cr yeast: n=3 study). Compared with placebo, Cr yeast, brewer's yeast and Cr picolinate did not show statistically significant effects on A1C. Furthermore, compared to control, Cr chloride, Cr yeast and Cr picolinate showed no effect on FPG, however, brewer's yeast showed a statistically significant decrease in FPG -19.23 mg/dL (95% CI=-35.30 to -3.16, I(2)=21%, n=137). CONCLUSIONS: Cr supplementation with brewer's yeast may provide marginal benefits in lowering FPG in patients with T2DM compared to placebo however it did not have any effect on A1C. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/25971249/Effect_of_chromium_supplementation_on_glycated_hemoglobin_and_fasting_plasma_glucose_in_patients_with_diabetes_mellitus_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-14-14 DB - PRIME DP - Unbound Medicine ER -