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The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37.
Ophthalmology. 2015 Jul; 122(7):1471-9.O

Abstract

PURPOSE

To evaluate whether dietary intake of luteiin/zeaxanthin and B vitamins is associated with cataract prevalence and incidence.

DESIGN

Clinic-based, baseline cross-sectional and prospective cohort study designs.

PARTICIPANTS

Three thousand one hundred fifteen patients (6129 eyes) enrolled in the Age-Related Eye Disease Study 55 to 80 years of age followed up for mean of 9.6 years.

METHODS

Participants completed baseline food frequency questionnaires. Baseline and annual lens photographs were graded centrally. Multivariate models controlling for previously identified risk factors for cataracts tested for the association of cataracts with reported dietary intake, using the lowest quintile as reference.

MAIN OUTCOME MEASURES

Cataract surgery, cataract status (type and severity) at baseline, and development of cataracts.

RESULTS

At baseline, increased dietary riboflavin and B12 were associated inversely with nuclear and cortical lens opacities. In comparisons of persons with and without cataract, persons with the highest riboflavin intake versus those with the lowest intake had the following associations: mild nuclear cataract: odds ratio (OR), 0.78; 95% confidence interval (CI), 0.63-0.97; moderate nuclear cataract: OR, 0.62; 95% CI, 0.43-0.90; and mild cortical cataract: OR, 0.80; 95% CI, 0.65-0.99. For B12, the results were: mild nuclear cataract: OR, 0.78; 95% CI, 0.63-0.96; moderate nuclear cataract: OR, 0.62; 95% CI, 0.43-0.88; and mild cortical cataract: OR, 0.77; 95% CI, 0.63-0.95. Highest dietary B6 intake was associated with a decreased risk of moderate nuclear lens opacity developing compared with the lowest quintile (OR, 0.67; 95% CI, 0.45-0.99). Highest dietary intake levels of niacin and B12 were associated with a decreased risk of development of mild nuclear or mild cortical cataracts in participants not taking Centrum (Pfizer, New York, NY) multivitamins. For participants taking multivitamins during the study, the highest intake of dietary folate was associated with an increased risk of mild posterior subcapsular lens opacity development. No statistically significant associations were found between lutein plus zeaxanthin intake and presence at baseline or development of nuclear or cortical lens opacity outcomes.

CONCLUSIONS

These findings are consistent with earlier studies suggesting that dietary intake of B vitamins may affect the occurrence of age-related lens opacities. Further investigations are warranted.

Authors+Show Affiliations

National Eye Institute, National Institutes of Health, Bethesda, Maryland.National Eye Institute, National Institutes of Health, Bethesda, Maryland.National Eye Institute, National Institutes of Health, Bethesda, Maryland.National Eye Institute, National Institutes of Health, Bethesda, Maryland.EMMES Corporation, Rockville, Maryland.National Eye Institute, National Institutes of Health, Bethesda, Maryland.National Eye Institute, National Institutes of Health, Bethesda, Maryland.EMMES Corporation, Rockville, Maryland.National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: echew@nei.nih.gov.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25972257

Citation

Glaser, Tanya S., et al. "The Association of Dietary Lutein Plus Zeaxanthin and B Vitamins With Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37." Ophthalmology, vol. 122, no. 7, 2015, pp. 1471-9.
Glaser TS, Doss LE, Shih G, et al. The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37. Ophthalmology. 2015;122(7):1471-9.
Glaser, T. S., Doss, L. E., Shih, G., Nigam, D., Sperduto, R. D., Ferris, F. L., Agrón, E., Clemons, T. E., & Chew, E. Y. (2015). The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37. Ophthalmology, 122(7), 1471-9. https://doi.org/10.1016/j.ophtha.2015.04.007
Glaser TS, et al. The Association of Dietary Lutein Plus Zeaxanthin and B Vitamins With Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37. Ophthalmology. 2015;122(7):1471-9. PubMed PMID: 25972257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37. AU - Glaser,Tanya S, AU - Doss,Lauren E, AU - Shih,Grace, AU - Nigam,Divya, AU - Sperduto,Robert D, AU - Ferris,Frederick L,3rd AU - Agrón,Elvira, AU - Clemons,Traci E, AU - Chew,Emily Y, AU - ,, Y1 - 2015/05/09/ PY - 2015/01/20/received PY - 2015/03/27/revised PY - 2015/04/06/accepted PY - 2015/5/15/entrez PY - 2015/5/15/pubmed PY - 2015/9/26/medline SP - 1471 EP - 9 JF - Ophthalmology JO - Ophthalmology VL - 122 IS - 7 N2 - PURPOSE: To evaluate whether dietary intake of luteiin/zeaxanthin and B vitamins is associated with cataract prevalence and incidence. DESIGN: Clinic-based, baseline cross-sectional and prospective cohort study designs. PARTICIPANTS: Three thousand one hundred fifteen patients (6129 eyes) enrolled in the Age-Related Eye Disease Study 55 to 80 years of age followed up for mean of 9.6 years. METHODS: Participants completed baseline food frequency questionnaires. Baseline and annual lens photographs were graded centrally. Multivariate models controlling for previously identified risk factors for cataracts tested for the association of cataracts with reported dietary intake, using the lowest quintile as reference. MAIN OUTCOME MEASURES: Cataract surgery, cataract status (type and severity) at baseline, and development of cataracts. RESULTS: At baseline, increased dietary riboflavin and B12 were associated inversely with nuclear and cortical lens opacities. In comparisons of persons with and without cataract, persons with the highest riboflavin intake versus those with the lowest intake had the following associations: mild nuclear cataract: odds ratio (OR), 0.78; 95% confidence interval (CI), 0.63-0.97; moderate nuclear cataract: OR, 0.62; 95% CI, 0.43-0.90; and mild cortical cataract: OR, 0.80; 95% CI, 0.65-0.99. For B12, the results were: mild nuclear cataract: OR, 0.78; 95% CI, 0.63-0.96; moderate nuclear cataract: OR, 0.62; 95% CI, 0.43-0.88; and mild cortical cataract: OR, 0.77; 95% CI, 0.63-0.95. Highest dietary B6 intake was associated with a decreased risk of moderate nuclear lens opacity developing compared with the lowest quintile (OR, 0.67; 95% CI, 0.45-0.99). Highest dietary intake levels of niacin and B12 were associated with a decreased risk of development of mild nuclear or mild cortical cataracts in participants not taking Centrum (Pfizer, New York, NY) multivitamins. For participants taking multivitamins during the study, the highest intake of dietary folate was associated with an increased risk of mild posterior subcapsular lens opacity development. No statistically significant associations were found between lutein plus zeaxanthin intake and presence at baseline or development of nuclear or cortical lens opacity outcomes. CONCLUSIONS: These findings are consistent with earlier studies suggesting that dietary intake of B vitamins may affect the occurrence of age-related lens opacities. Further investigations are warranted. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/25972257/The_Association_of_Dietary_Lutein_plus_Zeaxanthin_and_B_Vitamins_with_Cataracts_in_the_Age_Related_Eye_Disease_Study:_AREDS_Report_No__37_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(15)00330-9 DB - PRIME DP - Unbound Medicine ER -