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Magnesium and disturbances in carbohydrate metabolism.
Diabetes Obes Metab 2015; 17(9):813-23DO

Abstract

Magnesium is actively involved in a number of metabolic reactions as an important co-factor, with special emphasis on carbohydrate metabolism. After a brief overview of the regulation of intra- and extracellular magnesium, the present review first describes the regulatory role of magnesium in important metabolic pathways involved in energy metabolism and glycaemic control. Next the clinical significance of hypomagnesaemic conditions with regard to the management of glucose in prediabetic stages, such as insulin resistance/impaired glucose tolerance and in type 2 diabetes mellitus are characterized. Cross-sectional as well as longitudinal studies suggest that a reduced dietary magnesium intake serves as a risk factor for the incidence of both impaired glucose regulation and type 2 diabetes. Mechanisms that might be responsible for diabetes-associated hypomagnesaemia are discussed. Furthermore, the role of hypomagnesaemia in the development and progression of chronic diabetic complications are addressed. Finally, the available literature on the effects of magnesium supplementation on glycaemic control parameters during prediabetic conditions (preventive approach) as well as type 2 diabetes mellitus (therapeutic approach) are reviewed systematically. There is considerable evidence that chronic magnesium supplementation may delay the progression from impaired glucose regulation to type 2 diabetes; however, the effects of oral magnesium supplementation as an adjunct therapy for type 2 diabetes are quite heterogeneous with respect to the various measures of glycaemic control. The results of this review suggest a requirement for critical consideration of the pros and cons of magnesium replacement therapy, based on variables such as magnesium status, stage of disease and glycaemic control.

Authors+Show Affiliations

Department of Sports Medicine, Institute of Sports Sciences, Justus-Liebig-University, Giessen, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25974209

Citation

Mooren, Frank C.. "Magnesium and Disturbances in Carbohydrate Metabolism." Diabetes, Obesity & Metabolism, vol. 17, no. 9, 2015, pp. 813-23.
Mooren FC. Magnesium and disturbances in carbohydrate metabolism. Diabetes Obes Metab. 2015;17(9):813-23.
Mooren, F. C. (2015). Magnesium and disturbances in carbohydrate metabolism. Diabetes, Obesity & Metabolism, 17(9), pp. 813-23. doi:10.1111/dom.12492.
Mooren FC. Magnesium and Disturbances in Carbohydrate Metabolism. Diabetes Obes Metab. 2015;17(9):813-23. PubMed PMID: 25974209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium and disturbances in carbohydrate metabolism. A1 - Mooren,Frank C, Y1 - 2015/06/23/ PY - 2015/02/17/received PY - 2015/05/04/revised PY - 2015/05/08/accepted PY - 2015/5/15/entrez PY - 2015/5/15/pubmed PY - 2016/6/1/medline KW - glycaemic control KW - hypomagnesaemia KW - impaired glucose regulation KW - insulin resistance KW - type 2 diabetes mellitus SP - 813 EP - 23 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 17 IS - 9 N2 - Magnesium is actively involved in a number of metabolic reactions as an important co-factor, with special emphasis on carbohydrate metabolism. After a brief overview of the regulation of intra- and extracellular magnesium, the present review first describes the regulatory role of magnesium in important metabolic pathways involved in energy metabolism and glycaemic control. Next the clinical significance of hypomagnesaemic conditions with regard to the management of glucose in prediabetic stages, such as insulin resistance/impaired glucose tolerance and in type 2 diabetes mellitus are characterized. Cross-sectional as well as longitudinal studies suggest that a reduced dietary magnesium intake serves as a risk factor for the incidence of both impaired glucose regulation and type 2 diabetes. Mechanisms that might be responsible for diabetes-associated hypomagnesaemia are discussed. Furthermore, the role of hypomagnesaemia in the development and progression of chronic diabetic complications are addressed. Finally, the available literature on the effects of magnesium supplementation on glycaemic control parameters during prediabetic conditions (preventive approach) as well as type 2 diabetes mellitus (therapeutic approach) are reviewed systematically. There is considerable evidence that chronic magnesium supplementation may delay the progression from impaired glucose regulation to type 2 diabetes; however, the effects of oral magnesium supplementation as an adjunct therapy for type 2 diabetes are quite heterogeneous with respect to the various measures of glycaemic control. The results of this review suggest a requirement for critical consideration of the pros and cons of magnesium replacement therapy, based on variables such as magnesium status, stage of disease and glycaemic control. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/25974209/Magnesium_and_disturbances_in_carbohydrate_metabolism_ L2 - https://doi.org/10.1111/dom.12492 DB - PRIME DP - Unbound Medicine ER -