Tags

Type your tag names separated by a space and hit enter

Burden of invasive pneumococcal disease (IPD) in Sri-Lanka: Deriving a reasonable measure for vaccine introduction decision making.
Vaccine. 2015 Jun 17; 33(27):3122-8.V

Abstract

PURPOSE

The lack of evidence on the disease burden has been an obstacle for decision-making on introducing pneumococcal vaccines in Sri-Lanka. Hence, the purpose of this study is to determine the incidence of invasive pneumococcal disease among children under five-years of age in Sri-Lanka's Colombo district.

METHODS

In a community-based study, using a sample of 2310 children, we identified syndromes associated with pneumococcal disease (pneumonia, meningitis, sepsis). The estimates of annual cumulative incidence of invasive pneumococcal disease were derived by having applied proportions of laboratory confirmed invasive pneumococcal disease among all-cause syndromes associated with pneumococcal infection obtained from the hospital-based invasive bacterial disease sentinel surveillance and findings of the community-based study to population parameters of the district. The estimates of invasive pneumococcal pneumonia and sepsis based on low-sensitive, culture confirmation were adjusted by a correction factor.

RESULTS

The annual cumulative incidence of all-cause clinical syndromes associated with pneumococcal disease (pneumonia, meningitis, sepsis) were 1.3, 0.52, 0.39 per 100 children, respectively. The estimate of adjusted, invasive pneumococcal disease cumulative incidence was 206.3 per 100,000 while estimates of pneumococcal pneumonia, meningitis and sepsis cumulative incidence were 147.9, 13.2 and 45.2 per 100,000 under-five children.

CONCLUSION

Reasonable estimates of invasive pneumococcal disease could be derived by using incidence of clinical syndromes associated with pneumococcal disease obtained from population-based studies and proportion of pneumococcal infection among all-cause clinical syndromes associated with pneumococcal disease generated from hospital-based sentinel surveillance. These estimates may help informed decision-making on introduction of pneumococcal conjugated vaccine.

Authors+Show Affiliations

Ministry of Health, Colombo, Sri Lanka. Electronic address: s.kularatna@griffith.edu.au.Epidemiology Unit, Ministry of Health, Sri Lanka. Electronic address: ranjanwijesinghe@gmail.com.Epidemiology Unit, Ministry of Health, Sri Lanka. Electronic address: abeysinghen@who.int.Lady Ridgeway Children's Hospital (LRH), Colombo, Sri Lanka. Electronic address: kumudukaru@yahoo.com.Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka. Electronic address: lilanie@pdn.ac.lk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25976543

Citation

Kularatna, S, et al. "Burden of Invasive Pneumococcal Disease (IPD) in Sri-Lanka: Deriving a Reasonable Measure for Vaccine Introduction Decision Making." Vaccine, vol. 33, no. 27, 2015, pp. 3122-8.
Kularatna S, Wijesinghe PR, Abeysinghe MR, et al. Burden of invasive pneumococcal disease (IPD) in Sri-Lanka: Deriving a reasonable measure for vaccine introduction decision making. Vaccine. 2015;33(27):3122-8.
Kularatna, S., Wijesinghe, P. R., Abeysinghe, M. R., Karunaratne, K., & Ekanayake, L. (2015). Burden of invasive pneumococcal disease (IPD) in Sri-Lanka: Deriving a reasonable measure for vaccine introduction decision making. Vaccine, 33(27), 3122-8. https://doi.org/10.1016/j.vaccine.2015.04.093
Kularatna S, et al. Burden of Invasive Pneumococcal Disease (IPD) in Sri-Lanka: Deriving a Reasonable Measure for Vaccine Introduction Decision Making. Vaccine. 2015 Jun 17;33(27):3122-8. PubMed PMID: 25976543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burden of invasive pneumococcal disease (IPD) in Sri-Lanka: Deriving a reasonable measure for vaccine introduction decision making. AU - Kularatna,S, AU - Wijesinghe,P R, AU - Abeysinghe,M R N, AU - Karunaratne,K, AU - Ekanayake,L, Y1 - 2015/05/11/ PY - 2015/01/14/received PY - 2015/04/20/revised PY - 2015/04/28/accepted PY - 2015/5/16/entrez PY - 2015/5/16/pubmed PY - 2016/2/26/medline KW - Incidence KW - Invasive pneumococcal disease KW - Pneumococcal vaccine KW - Sri-Lanka SP - 3122 EP - 8 JF - Vaccine JO - Vaccine VL - 33 IS - 27 N2 - PURPOSE: The lack of evidence on the disease burden has been an obstacle for decision-making on introducing pneumococcal vaccines in Sri-Lanka. Hence, the purpose of this study is to determine the incidence of invasive pneumococcal disease among children under five-years of age in Sri-Lanka's Colombo district. METHODS: In a community-based study, using a sample of 2310 children, we identified syndromes associated with pneumococcal disease (pneumonia, meningitis, sepsis). The estimates of annual cumulative incidence of invasive pneumococcal disease were derived by having applied proportions of laboratory confirmed invasive pneumococcal disease among all-cause syndromes associated with pneumococcal infection obtained from the hospital-based invasive bacterial disease sentinel surveillance and findings of the community-based study to population parameters of the district. The estimates of invasive pneumococcal pneumonia and sepsis based on low-sensitive, culture confirmation were adjusted by a correction factor. RESULTS: The annual cumulative incidence of all-cause clinical syndromes associated with pneumococcal disease (pneumonia, meningitis, sepsis) were 1.3, 0.52, 0.39 per 100 children, respectively. The estimate of adjusted, invasive pneumococcal disease cumulative incidence was 206.3 per 100,000 while estimates of pneumococcal pneumonia, meningitis and sepsis cumulative incidence were 147.9, 13.2 and 45.2 per 100,000 under-five children. CONCLUSION: Reasonable estimates of invasive pneumococcal disease could be derived by using incidence of clinical syndromes associated with pneumococcal disease obtained from population-based studies and proportion of pneumococcal infection among all-cause clinical syndromes associated with pneumococcal disease generated from hospital-based sentinel surveillance. These estimates may help informed decision-making on introduction of pneumococcal conjugated vaccine. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/25976543/Burden_of_invasive_pneumococcal_disease__IPD__in_Sri_Lanka:_Deriving_a_reasonable_measure_for_vaccine_introduction_decision_making_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(15)00590-3 DB - PRIME DP - Unbound Medicine ER -