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Coenzyme Q10 and statin-related myopathy.
Drug Ther Bull. 2015 May; 53(5):54-6.DT

Abstract

Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is involved in the production of mevalonic acid in the cholesterol biosynthesis pathway. This pathway also results in the production of other bioactive molecules including coenzyme Q10 (also known as ubiquinone or ubidecarenone). Coenzyme Q10 is a naturally-occurring coenzyme with antioxidant effects that is involved in electron transport in mitochondria and is thought to play a role in energy transfer in skeletal muscle. Muscle-related problems are a frequently reported adverse effect of statins, and it has been hypothesised that a reduced endogenous coenzyme Q10 concentration is a cause of statin-induced myopathy. Coenzyme Q10 supplementation has therefore been proposed to reduce the adverse muscular effects sometimes seen with statins. Here, we consider whether coenzyme Q10 has a place in the management of statin-induced myopathy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25977402

Citation

"Coenzyme Q10 and Statin-related Myopathy." Drug and Therapeutics Bulletin, vol. 53, no. 5, 2015, pp. 54-6.
Coenzyme Q10 and statin-related myopathy. Drug Ther Bull. 2015;53(5):54-6.
(2015). Coenzyme Q10 and statin-related myopathy. Drug and Therapeutics Bulletin, 53(5), 54-6. https://doi.org/10.1136/dtb.2015.5.0325
Coenzyme Q10 and Statin-related Myopathy. Drug Ther Bull. 2015;53(5):54-6. PubMed PMID: 25977402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 and statin-related myopathy. PY - 2015/5/16/entrez PY - 2015/5/16/pubmed PY - 2016/5/6/medline SP - 54 EP - 6 JF - Drug and therapeutics bulletin JO - Drug Ther Bull VL - 53 IS - 5 N2 - Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is involved in the production of mevalonic acid in the cholesterol biosynthesis pathway. This pathway also results in the production of other bioactive molecules including coenzyme Q10 (also known as ubiquinone or ubidecarenone). Coenzyme Q10 is a naturally-occurring coenzyme with antioxidant effects that is involved in electron transport in mitochondria and is thought to play a role in energy transfer in skeletal muscle. Muscle-related problems are a frequently reported adverse effect of statins, and it has been hypothesised that a reduced endogenous coenzyme Q10 concentration is a cause of statin-induced myopathy. Coenzyme Q10 supplementation has therefore been proposed to reduce the adverse muscular effects sometimes seen with statins. Here, we consider whether coenzyme Q10 has a place in the management of statin-induced myopathy. SN - 1755-5248 UR - https://www.unboundmedicine.com/medline/citation/25977402/Coenzyme_Q10_and_statin_related_myopathy_ L2 - http://dtb.bmj.com/cgi/pmidlookup?view=long&pmid=25977402 DB - PRIME DP - Unbound Medicine ER -