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Normal range albuminuria and metabolic syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey.

Abstract

BACKGROUND

It is well-known that there is a close relationship between metabolic syndrome (MetS) and microalbuminuria. However, some recent studies have found that even normal range albuminuria was associated with MetS and cardiometabolic risk factors. The purpose of this study is to analyze the relationship between MetS and normal range albuminuria and to calculate the cutoff value for albuminuria that correlates with MetS in the representative fraction of Korean population.

METHODS

Data were obtained from the 2011-2012 Korea National Health and Nutrition Examination Survey and included 9,650 subjects aged ≥ 19 years. We measured metabolic parameters: fasting blood glucose, waist circumference, blood pressure, and lipids, and albumin-to-creatinine ratio (ACR). The optimal ACR cutoff points for MetS were examined by the receiver operating characteristic curve. Multivariate logistic regression was used to obtain the prevalence of MetS and its components according to the ACR levels.

RESULTS

The first cutoff value of ACR were 4.8 mg/g for subjects with ≥ 3 components of MetS. There was a graded association between ACR and prevalence of MetS and its components. If ACR was <4 mg/g, there was no significant increase in the prevalence of MetS or its components. From the ACR level of 4-5 mg/g, the prevalence of MetS significantly increased after adjusting for age, sex, body mass index, smoking, alcohol intake, exercise, and medications for diabetes mellitus and hypertension (odds ratio; 95% confidence intervals = 1.416; 1.041-1.926).

CONCLUSIONS

Albuminuria within the normal range (around 5 mg/g) was associated with prevalence of MetS in the Korean population.

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  • Authors+Show Affiliations

    ,

    Department of Family Medicine, Eulji University College of Medicine, Daejeon, South Korea.

    ,

    Department of Medical Statistics, Catholic University College of Medicine, Seoul, South Korea.

    ,

    Department of Family Medicine, Korea University College of Medicine, Seoul, South Korea.

    ,

    Department of Family Medicine, Eulji University College of Medicine, Daejeon, South Korea.

    ,

    Department of Family Medicine, Eulji University College of Medicine, Daejeon, South Korea.

    ,

    Department of Medical Statistics, Catholic University College of Medicine, Seoul, South Korea.

    ,

    Department of Family Medicine, Korea University College of Medicine, Seoul, South Korea.

    ,

    Department of Family Medicine, Korea University College of Medicine, Seoul, South Korea.

    Department of Family Medicine, Korea University College of Medicine, Seoul, South Korea.

    Source

    PloS one 10:5 2015 pg e0125615

    MeSH

    Adult
    Albuminuria
    Blood Pressure
    Female
    Humans
    Male
    Metabolic Syndrome
    Middle Aged
    Multivariate Analysis
    Nutrition Surveys
    Republic of Korea
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25978637

    Citation

    Park, Si-Young, et al. "Normal Range Albuminuria and Metabolic Syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey." PloS One, vol. 10, no. 5, 2015, pp. e0125615.
    Park SY, Park YK, Cho KH, et al. Normal range albuminuria and metabolic syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey. PLoS ONE. 2015;10(5):e0125615.
    Park, S. Y., Park, Y. K., Cho, K. H., Choi, H. J., Han, J. H., Han, K. D., ... Kim, Y. H. (2015). Normal range albuminuria and metabolic syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey. PloS One, 10(5), pp. e0125615. doi:10.1371/journal.pone.0125615.
    Park SY, et al. Normal Range Albuminuria and Metabolic Syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey. PLoS ONE. 2015;10(5):e0125615. PubMed PMID: 25978637.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Normal range albuminuria and metabolic syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey. AU - Park,Si-Young, AU - Park,Yong-Kyu, AU - Cho,Kyung-Hwan, AU - Choi,Hee-Jeong, AU - Han,Jee-Hye, AU - Han,Kyung-Do, AU - Han,Byung-Duck, AU - Yoon,Yeo-Joon, AU - Kim,Yang-Hyun, Y1 - 2015/05/15/ PY - 2015/01/05/received PY - 2015/03/24/accepted PY - 2015/5/16/entrez PY - 2015/5/16/pubmed PY - 2016/3/5/medline SP - e0125615 EP - e0125615 JF - PloS one JO - PLoS ONE VL - 10 IS - 5 N2 - BACKGROUND: It is well-known that there is a close relationship between metabolic syndrome (MetS) and microalbuminuria. However, some recent studies have found that even normal range albuminuria was associated with MetS and cardiometabolic risk factors. The purpose of this study is to analyze the relationship between MetS and normal range albuminuria and to calculate the cutoff value for albuminuria that correlates with MetS in the representative fraction of Korean population. METHODS: Data were obtained from the 2011-2012 Korea National Health and Nutrition Examination Survey and included 9,650 subjects aged ≥ 19 years. We measured metabolic parameters: fasting blood glucose, waist circumference, blood pressure, and lipids, and albumin-to-creatinine ratio (ACR). The optimal ACR cutoff points for MetS were examined by the receiver operating characteristic curve. Multivariate logistic regression was used to obtain the prevalence of MetS and its components according to the ACR levels. RESULTS: The first cutoff value of ACR were 4.8 mg/g for subjects with ≥ 3 components of MetS. There was a graded association between ACR and prevalence of MetS and its components. If ACR was <4 mg/g, there was no significant increase in the prevalence of MetS or its components. From the ACR level of 4-5 mg/g, the prevalence of MetS significantly increased after adjusting for age, sex, body mass index, smoking, alcohol intake, exercise, and medications for diabetes mellitus and hypertension (odds ratio; 95% confidence intervals = 1.416; 1.041-1.926). CONCLUSIONS: Albuminuria within the normal range (around 5 mg/g) was associated with prevalence of MetS in the Korean population. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25978637/Normal_range_albuminuria_and_metabolic_syndrome_in_South_Korea:_the_2011_2012_Korean_National_Health_and_Nutrition_Examination_Survey_ L2 - http://dx.plos.org/10.1371/journal.pone.0125615 DB - PRIME DP - Unbound Medicine ER -