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Association between apolipoprotein E gene polymorphism and depression.
J Clin Neurosci. 2015 Aug; 22(8):1232-8.JC

Abstract

We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent. Twenty studies with 2286 depression patients and 3845 controls were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between ApoE gene polymorphism and depression using a random effects model. Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59-0.99). Subgroup analyses indicated an association in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58-0.97) as well as in late-life depression (LLD) patients (ε3/ε4 genotype versus ε3/ε3: OR 1.34, 95% CI 1.07-1.68, and ε4 allele versus ε3: OR 1.30, 95% CI 1.06-1.59). We concluded that the ε2/ε3 genotype likely provided a protective effect against depression in the overall population and the ε2 allele acted as a protective factor for depression in the Caucasian population while the ε4 allele and ε3/ε4 genotype were associated with an increased risk of depression in the LLD subjects.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: pbi_ahmu_edu@126.com.Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; Centre for Evidence-Based Practice, Anhui Medical University, Hefei, Anhui, China. Electronic address: yhsun_ahmu_edu@yeah.net.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25979253

Citation

Feng, Fang, et al. "Association Between Apolipoprotein E Gene Polymorphism and Depression." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 22, no. 8, 2015, pp. 1232-8.
Feng F, Lu SS, Hu CY, et al. Association between apolipoprotein E gene polymorphism and depression. J Clin Neurosci. 2015;22(8):1232-8.
Feng, F., Lu, S. S., Hu, C. Y., Gong, F. F., Qian, Z. Z., Yang, H. Y., Wu, Y. L., Zhao, Y. Y., Bi, P., & Sun, Y. H. (2015). Association between apolipoprotein E gene polymorphism and depression. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 22(8), 1232-8. https://doi.org/10.1016/j.jocn.2015.02.012
Feng F, et al. Association Between Apolipoprotein E Gene Polymorphism and Depression. J Clin Neurosci. 2015;22(8):1232-8. PubMed PMID: 25979253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E gene polymorphism and depression. AU - Feng,Fang, AU - Lu,Shan-Shan, AU - Hu,Cai-Yun, AU - Gong,Feng-Feng, AU - Qian,Zhen-Zhong, AU - Yang,Hui-Yun, AU - Wu,Yi-Le, AU - Zhao,Yuan-Yuan, AU - Bi,Peng, AU - Sun,Ye-Huan, Y1 - 2015/05/12/ PY - 2014/08/27/received PY - 2015/01/21/revised PY - 2015/02/02/accepted PY - 2015/5/17/entrez PY - 2015/5/17/pubmed PY - 2016/2/2/medline KW - ApoE KW - Apolipoprotein E KW - Depression KW - Meta-analysis KW - Polymorphism SP - 1232 EP - 8 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 22 IS - 8 N2 - We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent. Twenty studies with 2286 depression patients and 3845 controls were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between ApoE gene polymorphism and depression using a random effects model. Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59-0.99). Subgroup analyses indicated an association in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58-0.97) as well as in late-life depression (LLD) patients (ε3/ε4 genotype versus ε3/ε3: OR 1.34, 95% CI 1.07-1.68, and ε4 allele versus ε3: OR 1.30, 95% CI 1.06-1.59). We concluded that the ε2/ε3 genotype likely provided a protective effect against depression in the overall population and the ε2 allele acted as a protective factor for depression in the Caucasian population while the ε4 allele and ε3/ε4 genotype were associated with an increased risk of depression in the LLD subjects. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/25979253/Association_between_apolipoprotein_E_gene_polymorphism_and_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(15)00108-3 DB - PRIME DP - Unbound Medicine ER -