Tags

Type your tag names separated by a space and hit enter

Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol.
BMJ Open. 2015 May 15; 5(5):e007689.BO

Abstract

INTRODUCTION

Fructosamine is a marker of glucose control reflecting the average glycaemic level over the preceding 2-3 weeks. Fructosamine has not gained as much popularity as glycated haemoglobin (HbA1c) for diabetes mellitus (DM) control monitoring, and the related underlying reasons remain unclear. We aim to search for and summarise available evidence on the accuracy of fructosamine measurements to diagnose and monitor DM.

METHODS AND ANALYSIS

This systematic review will include randomised control trials, controlled before-and-after studies, time series designs, cohort studies, case-control studies and cross-sectional surveys reporting the diagnosis and/or monitoring of DM (type 1 DM, type 2 DM and gestational DM) with fructosamine compared with other measures of glycaemia (fasting glucose, oral glucose tolerance test, random glucose, HbA1c), without any language restriction. We will perform electronic searches in PubMed, Scopus and other databases, supplemented with manual searches. Articles published from 1 January 1980 to 30 June 2015 will be eligible for inclusion in this review. Two authors will independently screen, select studies, extract data and assess the risk of bias with discrepancies resolved by consensus. We will assess clinical heterogeneity by examining the types of interventions and outcomes in each study, and pool studies judged to be clinically homogeneous. We will also assess statistical heterogeneity using the χ(2) test of homogeneity and quantify it using the I(2) statistic. Absolute accuracy measures (sensitivity, specificity) will be pooled in a bivariate random-effects model, allowing for intersetting variability. Negative and positive predictive values will be computed for fructosamine, compared with another measure of glycaemia from the pooled estimates of sensitivity and specificity, using Bayes' theorem.

ETHICS AND DISSEMINATION

This systematic review will use data from published studies and does not require ethics approval. Findings will be published in a peer-reviewed journal and presented at scientific conferences.

TRIAL REGISTRATION NUMBER

PROSPERO (ID=CRD42015015930).

Links

PMC Free PDF

Authors+Show Affiliations

Nansseu JR
Sickle Cell Disease Unit, Mother and Child Centre, Chantal Biya Foundation, Yaoundé, Centre Region, Cameroon Department of Public Health, Faculty of Medicine, Biomedical Sciences of the University of Yaoundé I, Yaoundé, Centre Region, Cameroon.
Fokom-Domgue J
Department of Obstetrics and Gynecology, Faculty of Medicine, Biomedical Sciences of the University of Yaoundé I, Yaoundé, Centre Region, Cameroon.
Noubiap JJ
Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
Balti EV
National Obesity Centre, Yaoundé Central Hospital, Yaoundé, Centre Region, Cameroon Diabetes Research Centre, Brussels Free University-VUB, Brussels, Belgium Department of Clinical Chemistry and Radio-immunology, University Hospital Brussels-UZ Brussel, Brussels, Belgium.
Sobngwi E
National Obesity Centre, Yaoundé Central Hospital, Yaoundé, Centre Region, Cameroon Department of Medicine and Specialties, Faculty of Medicine, Biomedical Sciences of the University of Yaoundé I, Yaoundé, Cameroon.
Kengne AP
Non-communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, Cape Town, South Africa.

MeSH

Bayes TheoremBiomarkersBlood GlucoseDiabetes MellitusFructosamineGlucose Tolerance TestGlycated HemoglobinHumansPredictive Value of TestsSensitivity and SpecificitySystematic Reviews as Topic

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25979870

Citation

Nansseu, Jobert Richie N., et al. "Fructosamine Measurement for Diabetes Mellitus Diagnosis and Monitoring: a Systematic Review and Meta-analysis Protocol." BMJ Open, vol. 5, no. 5, 2015, pp. e007689.
Nansseu JR, Fokom-Domgue J, Noubiap JJ, et al. Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol. BMJ Open. 2015;5(5):e007689.
Nansseu, J. R., Fokom-Domgue, J., Noubiap, J. J., Balti, E. V., Sobngwi, E., & Kengne, A. P. (2015). Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol. BMJ Open, 5(5), e007689. https://doi.org/10.1136/bmjopen-2015-007689
Nansseu JR, et al. Fructosamine Measurement for Diabetes Mellitus Diagnosis and Monitoring: a Systematic Review and Meta-analysis Protocol. BMJ Open. 2015 May 15;5(5):e007689. PubMed PMID: 25979870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol. AU - Nansseu,Jobert Richie N, AU - Fokom-Domgue,Joël, AU - Noubiap,Jean Jacques N, AU - Balti,Eric V, AU - Sobngwi,Eugène, AU - Kengne,André Pascal, Y1 - 2015/05/15/ PY - 2015/5/17/entrez PY - 2015/5/17/pubmed PY - 2016/2/10/medline KW - diabetes mellitus KW - diagnosis KW - fructosamine measurement KW - monitoring SP - e007689 EP - e007689 JF - BMJ open JO - BMJ Open VL - 5 IS - 5 N2 - INTRODUCTION: Fructosamine is a marker of glucose control reflecting the average glycaemic level over the preceding 2-3 weeks. Fructosamine has not gained as much popularity as glycated haemoglobin (HbA1c) for diabetes mellitus (DM) control monitoring, and the related underlying reasons remain unclear. We aim to search for and summarise available evidence on the accuracy of fructosamine measurements to diagnose and monitor DM. METHODS AND ANALYSIS: This systematic review will include randomised control trials, controlled before-and-after studies, time series designs, cohort studies, case-control studies and cross-sectional surveys reporting the diagnosis and/or monitoring of DM (type 1 DM, type 2 DM and gestational DM) with fructosamine compared with other measures of glycaemia (fasting glucose, oral glucose tolerance test, random glucose, HbA1c), without any language restriction. We will perform electronic searches in PubMed, Scopus and other databases, supplemented with manual searches. Articles published from 1 January 1980 to 30 June 2015 will be eligible for inclusion in this review. Two authors will independently screen, select studies, extract data and assess the risk of bias with discrepancies resolved by consensus. We will assess clinical heterogeneity by examining the types of interventions and outcomes in each study, and pool studies judged to be clinically homogeneous. We will also assess statistical heterogeneity using the χ(2) test of homogeneity and quantify it using the I(2) statistic. Absolute accuracy measures (sensitivity, specificity) will be pooled in a bivariate random-effects model, allowing for intersetting variability. Negative and positive predictive values will be computed for fructosamine, compared with another measure of glycaemia from the pooled estimates of sensitivity and specificity, using Bayes' theorem. ETHICS AND DISSEMINATION: This systematic review will use data from published studies and does not require ethics approval. Findings will be published in a peer-reviewed journal and presented at scientific conferences. TRIAL REGISTRATION NUMBER: PROSPERO (ID=CRD42015015930). SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/25979870/Fructosamine_measurement_for_diabetes_mellitus_diagnosis_and_monitoring:_a_systematic_review_and_meta_analysis_protocol_ DB - PRIME DP - Unbound Medicine ER -