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Middle latency response correlates of single and double deviant stimuli in a multi-feature paradigm.
Clin Neurophysiol. 2016 Jan; 127(1):388-396.CN

Abstract

OBJECTIVE

This study aimed to test single and double deviance-related modulations of the middle latency response (MLR) and the applicability of the optimum-2 multi-feature paradigm.

METHODS

The MLR and the MMN to frequency, intensity and double-feature deviants of an optimum-2 multi-feature paradigm and the MMN to double-feature deviants of an oddball paradigm were recorded in young adults.

RESULTS

Double deviants elicited significant enhancements of the Nb and Pb MLR waves compared with the waves elicited by standard stimuli. These enhancements equalled approximately the sum of the numerical amplitude differences elicited by the single deviants. In contrast, the MMN to double deviants did not show such additivity. MMNs elicited by double deviants of the multi-feature and the oddball paradigm showed no significant difference in amplitude or latency.

CONCLUSIONS

The optimum-2 multi-feature paradigm is suitable for recording double deviance-related modulations of the MLR. Interspersed intensity and frequency deviants in the standard trace of the optimum-2 condition multi-feature paradigm did not weaken the double MMN.

SIGNIFICANCE

The optimum-2 multi-feature paradigm could be especially beneficial for clinical studies on early deviance-related modulations in the MLR, due to its optimized utilization of the recording time.

Authors+Show Affiliations

Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain.Finnish Institute of Occupational Health, Helsinki, Finland; Cognitive Brain Research Unit, Institute for Behavioural Sciences, University of Helsinki, Finland.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain. Electronic address: cescera@ub.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25980983

Citation

Althen, H, et al. "Middle Latency Response Correlates of Single and Double Deviant Stimuli in a Multi-feature Paradigm." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 127, no. 1, 2016, pp. 388-396.
Althen H, Huotilainen M, Grimm S, et al. Middle latency response correlates of single and double deviant stimuli in a multi-feature paradigm. Clin Neurophysiol. 2016;127(1):388-396.
Althen, H., Huotilainen, M., Grimm, S., & Escera, C. (2016). Middle latency response correlates of single and double deviant stimuli in a multi-feature paradigm. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 127(1), 388-396. https://doi.org/10.1016/j.clinph.2015.04.058
Althen H, et al. Middle Latency Response Correlates of Single and Double Deviant Stimuli in a Multi-feature Paradigm. Clin Neurophysiol. 2016;127(1):388-396. PubMed PMID: 25980983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle latency response correlates of single and double deviant stimuli in a multi-feature paradigm. AU - Althen,H, AU - Huotilainen,M, AU - Grimm,S, AU - Escera,C, Y1 - 2015/04/24/ PY - 2014/05/13/received PY - 2015/03/01/revised PY - 2015/04/15/accepted PY - 2015/5/19/entrez PY - 2015/5/20/pubmed PY - 2016/5/14/medline KW - Auditory evoked potentials KW - Auditory novelty system KW - Double-feature deviants KW - Middle latency response (MLR) KW - Mismatch negativity (MMN) KW - Multi-feature paradigm SP - 388 EP - 396 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 127 IS - 1 N2 - OBJECTIVE: This study aimed to test single and double deviance-related modulations of the middle latency response (MLR) and the applicability of the optimum-2 multi-feature paradigm. METHODS: The MLR and the MMN to frequency, intensity and double-feature deviants of an optimum-2 multi-feature paradigm and the MMN to double-feature deviants of an oddball paradigm were recorded in young adults. RESULTS: Double deviants elicited significant enhancements of the Nb and Pb MLR waves compared with the waves elicited by standard stimuli. These enhancements equalled approximately the sum of the numerical amplitude differences elicited by the single deviants. In contrast, the MMN to double deviants did not show such additivity. MMNs elicited by double deviants of the multi-feature and the oddball paradigm showed no significant difference in amplitude or latency. CONCLUSIONS: The optimum-2 multi-feature paradigm is suitable for recording double deviance-related modulations of the MLR. Interspersed intensity and frequency deviants in the standard trace of the optimum-2 condition multi-feature paradigm did not weaken the double MMN. SIGNIFICANCE: The optimum-2 multi-feature paradigm could be especially beneficial for clinical studies on early deviance-related modulations in the MLR, due to its optimized utilization of the recording time. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/25980983/Middle_latency_response_correlates_of_single_and_double_deviant_stimuli_in_a_multi_feature_paradigm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(15)00296-5 DB - PRIME DP - Unbound Medicine ER -