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Dietary fibre and the risk of colorectal cancer: a case- control study.

Abstract

BACKGROUND

Colorectal cancer is one of the most commonly occurring cancers in China. Dietary fibre has been thought to decrease the risk of colorectal cancer in Western countries. However, studies investigating the association between dietary fibre (particularly soluble and insoluble fibres) and colorectal cancer have hitherto been lacking in China.

OBJECTIVE

This case-control study examined the effect of dietary fibre intake on the risk of colorectal cancer, stratified by tumour site.

MATERIALS AND METHODS

The study included 265 cases (colon cancer, 105; rectal cancer, 144; colon and rectal cancer, 16) and 252 controls residing in Qingdao. A food frequency questionnaire that included 121 food items was used to collect dietary information. Odds ratio (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression analysis.

RESULTS

For food groups, controls in the study consumed more vegetables, soy food and total fibre than did colorectal cancer patients (p<0.05). The intakes of fruit, meat and sea-food did not differ significantly between cases and controls. However, we did not find any association between soy food intake and colon cancer. We observed inverse associations between total fibre intake and colorectal, colon and rectal cancer (Q4 vs Q1: OR=0.44, 95%CI, 0.27- 0.73; OR=0.40, 95%CI, 0.21-0.76; OR=0.52, 95%CI, 0.29-0.91). Vegetable fibre intake showed similar inverse associations (Q4 vs Q1: OR=0.51, 95%CI, 0.31-0.85; OR=0.48, 95%CI, 0.25-0.91; OR=0.53, 95%CI, 0.29-0.97). In addition, inverse associations were observed between soluble fibre and insoluble fibre and both colorectal cancer and colon cancer. No relationship was found between colorectal cancer and fruit, soy or grain fibre intakewhen the results were stratified by tumour site.

CONCLUSIONS

The present study suggests that vegetable fibre and total fibre play very important roles in protecting against colorectal cancer. Soluble and insoluble fibres were inversely associated with only colorectal cancer and colon cancer.

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  • Authors+Show Affiliations

    ,

    Department of Public Health, Medical College, Qingdao University, Qingdao, Shandong, China E-mail : qdsongyang@126.com.

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Case-Control Studies
    China
    Colorectal Neoplasms
    Dietary Fiber
    Female
    Follow-Up Studies
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Prognosis
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25987032

    Citation

    Song, Y, et al. "Dietary Fibre and the Risk of Colorectal Cancer: a Case- Control Study." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 16, no. 9, 2015, pp. 3747-52.
    Song Y, Liu M, Yang FG, et al. Dietary fibre and the risk of colorectal cancer: a case- control study. Asian Pac J Cancer Prev. 2015;16(9):3747-52.
    Song, Y., Liu, M., Yang, F. G., Cui, L. H., Lu, X. Y., & Chen, C. (2015). Dietary fibre and the risk of colorectal cancer: a case- control study. Asian Pacific Journal of Cancer Prevention : APJCP, 16(9), pp. 3747-52.
    Song Y, et al. Dietary Fibre and the Risk of Colorectal Cancer: a Case- Control Study. Asian Pac J Cancer Prev. 2015;16(9):3747-52. PubMed PMID: 25987032.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fibre and the risk of colorectal cancer: a case- control study. AU - Song,Y, AU - Liu,M, AU - Yang,F G, AU - Cui,L H, AU - Lu,X Y, AU - Chen,C, PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2016/2/18/medline SP - 3747 EP - 52 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 16 IS - 9 N2 - BACKGROUND: Colorectal cancer is one of the most commonly occurring cancers in China. Dietary fibre has been thought to decrease the risk of colorectal cancer in Western countries. However, studies investigating the association between dietary fibre (particularly soluble and insoluble fibres) and colorectal cancer have hitherto been lacking in China. OBJECTIVE: This case-control study examined the effect of dietary fibre intake on the risk of colorectal cancer, stratified by tumour site. MATERIALS AND METHODS: The study included 265 cases (colon cancer, 105; rectal cancer, 144; colon and rectal cancer, 16) and 252 controls residing in Qingdao. A food frequency questionnaire that included 121 food items was used to collect dietary information. Odds ratio (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression analysis. RESULTS: For food groups, controls in the study consumed more vegetables, soy food and total fibre than did colorectal cancer patients (p<0.05). The intakes of fruit, meat and sea-food did not differ significantly between cases and controls. However, we did not find any association between soy food intake and colon cancer. We observed inverse associations between total fibre intake and colorectal, colon and rectal cancer (Q4 vs Q1: OR=0.44, 95%CI, 0.27- 0.73; OR=0.40, 95%CI, 0.21-0.76; OR=0.52, 95%CI, 0.29-0.91). Vegetable fibre intake showed similar inverse associations (Q4 vs Q1: OR=0.51, 95%CI, 0.31-0.85; OR=0.48, 95%CI, 0.25-0.91; OR=0.53, 95%CI, 0.29-0.97). In addition, inverse associations were observed between soluble fibre and insoluble fibre and both colorectal cancer and colon cancer. No relationship was found between colorectal cancer and fruit, soy or grain fibre intakewhen the results were stratified by tumour site. CONCLUSIONS: The present study suggests that vegetable fibre and total fibre play very important roles in protecting against colorectal cancer. Soluble and insoluble fibres were inversely associated with only colorectal cancer and colon cancer. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/25987032/Dietary_fibre_and_the_risk_of_colorectal_cancer:_a_case__control_study_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&amp;id=pmid:25987032&amp;key=2015.16.9.3747 DB - PRIME DP - Unbound Medicine ER -