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Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning.
Neuroimage. 2015 Aug 15; 117:11-9.N

Abstract

BACKGROUND

Declarative verbal learning and memory are known to be lateralised to the dominant hemisphere and to be subserved by a network of structures, including those located in frontal and temporal regions. These structures support critical components of verbal memory, including working memory, encoding, and retrieval. Their relative functional importance in facilitating declarative verbal learning and memory, however, remains unclear.

OBJECTIVE

To investigate the different functional roles of these structures in subserving declarative verbal learning and memory performance by applying a more focal form of transcranial direct current stimulation, "High Definition tDCS" (HD-tDCS). Additionally, we sought to examine HD-tDCS effects and electrical field intensity distributions using computer modelling.

METHODS

HD-tDCS was administered to the left dorsolateral prefrontal cortex (LDLPFC), planum temporale (PT), and left medial temporal lobe (LMTL) to stimulate the hippocampus, during learning on a declarative verbal memory task. Sixteen healthy participants completed a single blind, intra-individual cross-over, sham-controlled study which used a Latin Square experimental design. Cognitive effects on working memory and sustained attention were additionally examined.

RESULTS

HD-tDCS to the LDLPFC significantly improved the rate of verbal learning (p=0.03, η(2)=0.29) and speed of responding during working memory performance (p=0.02, η(2)=0.35), but not accuracy (p=0.12, η(2)=0.16). No effect of tDCS on verbal learning, retention, or retrieval was found for stimulation targeted to the LMTL or the PT. Secondary analyses revealed that LMTL stimulation resulted in increased recency (p=0.02, η(2)=0.31) and reduced mid-list learning effects (p=0.01, η(2)=0.39), suggesting an inhibitory effect on learning.

CONCLUSIONS

HD-tDCS to the LDLPFC facilitates the rate of verbal learning and improved efficiency of working memory may underlie performance effects. This focal method of administrating tDCS has potential for probing and enhancing cognitive functioning.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia.School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia; St. George Hospital, Sydney, Australia.Faculty of Engineering, University of New South Wales, Sydney, Australia; IMETUM, Technische Universität München, 85748 Garching, Germany.Faculty of Engineering, University of New South Wales, Sydney, Australia.School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, Australia. Electronic address: donel.martin@unsw.edu.au.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25987365

Citation

Nikolin, Stevan, et al. "Focalised Stimulation Using High Definition Transcranial Direct Current Stimulation (HD-tDCS) to Investigate Declarative Verbal Learning and Memory Functioning." NeuroImage, vol. 117, 2015, pp. 11-9.
Nikolin S, Loo CK, Bai S, et al. Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning. Neuroimage. 2015;117:11-9.
Nikolin, S., Loo, C. K., Bai, S., Dokos, S., & Martin, D. M. (2015). Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning. NeuroImage, 117, 11-9. https://doi.org/10.1016/j.neuroimage.2015.05.019
Nikolin S, et al. Focalised Stimulation Using High Definition Transcranial Direct Current Stimulation (HD-tDCS) to Investigate Declarative Verbal Learning and Memory Functioning. Neuroimage. 2015 Aug 15;117:11-9. PubMed PMID: 25987365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning. AU - Nikolin,Stevan, AU - Loo,Colleen K, AU - Bai,Siwei, AU - Dokos,Socrates, AU - Martin,Donel M, Y1 - 2015/05/15/ PY - 2015/01/07/received PY - 2015/05/04/revised PY - 2015/05/07/accepted PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2016/4/16/medline KW - Declarative verbal memory KW - High definition transcranial direct current stimulation KW - Left dorsolateral prefrontal cortex KW - Left medial temporal lobe KW - Planum temporale SP - 11 EP - 9 JF - NeuroImage JO - Neuroimage VL - 117 N2 - BACKGROUND: Declarative verbal learning and memory are known to be lateralised to the dominant hemisphere and to be subserved by a network of structures, including those located in frontal and temporal regions. These structures support critical components of verbal memory, including working memory, encoding, and retrieval. Their relative functional importance in facilitating declarative verbal learning and memory, however, remains unclear. OBJECTIVE: To investigate the different functional roles of these structures in subserving declarative verbal learning and memory performance by applying a more focal form of transcranial direct current stimulation, "High Definition tDCS" (HD-tDCS). Additionally, we sought to examine HD-tDCS effects and electrical field intensity distributions using computer modelling. METHODS: HD-tDCS was administered to the left dorsolateral prefrontal cortex (LDLPFC), planum temporale (PT), and left medial temporal lobe (LMTL) to stimulate the hippocampus, during learning on a declarative verbal memory task. Sixteen healthy participants completed a single blind, intra-individual cross-over, sham-controlled study which used a Latin Square experimental design. Cognitive effects on working memory and sustained attention were additionally examined. RESULTS: HD-tDCS to the LDLPFC significantly improved the rate of verbal learning (p=0.03, η(2)=0.29) and speed of responding during working memory performance (p=0.02, η(2)=0.35), but not accuracy (p=0.12, η(2)=0.16). No effect of tDCS on verbal learning, retention, or retrieval was found for stimulation targeted to the LMTL or the PT. Secondary analyses revealed that LMTL stimulation resulted in increased recency (p=0.02, η(2)=0.31) and reduced mid-list learning effects (p=0.01, η(2)=0.39), suggesting an inhibitory effect on learning. CONCLUSIONS: HD-tDCS to the LDLPFC facilitates the rate of verbal learning and improved efficiency of working memory may underlie performance effects. This focal method of administrating tDCS has potential for probing and enhancing cognitive functioning. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/25987365/Focalised_stimulation_using_high_definition_transcranial_direct_current_stimulation__HD_tDCS__to_investigate_declarative_verbal_learning_and_memory_functioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(15)00399-7 DB - PRIME DP - Unbound Medicine ER -