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Role of stimulated intrarenal angiotensinogen in hypertension.
Ther Adv Cardiovasc Dis. 2015 Aug; 9(4):181-90.TA

Abstract

Experimental models of hypertension and patients with inappropriately increased renin formation due to a stenotic kidney, arteriosclerotic narrowing of the renal arterioles or a rare juxtaglomerular cell tumor have shown a progressive augmentation of the intrarenal/intratubular renin-angiotensin system (RAS). The increased intrarenal angiotensin II (Ang II) elicits renal vasoconstriction and enhanced tubular sodium reabsorption in proximal and distal nephron segments. The enhanced intrarenal Ang II levels are due to both increased Ang II type 1 (AT1) receptor mediated Ang II uptake and AT1 receptor dependent stimulation of renal angiotensinogen (AGT) mRNA and augmented AGT production. The increased AGT formation and secretion into the proximal tubular lumen leads to local formation of Ang II, which stimulates proximal transporters such as the sodium/hydrogen exchanger. Enhanced AGT production also leads to spillover of AGT into the distal nephron segments as reflected by AGT in the urine, which provides an index of intrarenal RAS activity. There is also increased Ang II concentration in distal nephron with stimulation of distal sodium transport. Increased urinary excretion of AGT has been demonstrated in patients with hypertension, type 1 and type 2 diabetes mellitus, and several types of chronic kidney diseases indicating an upregulation of intrarenal RAS activity.

Authors+Show Affiliations

Department of Physiology and the Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA.Department of Physiology and the Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA.Department of Physiology, Tulane University Health Sciences Center, SL39, 1430 Tulane Avenue, New Orleans, LA 70112, USA navar@tulane.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

25987608

Citation

Satou, Ryousuke, et al. "Role of Stimulated Intrarenal Angiotensinogen in Hypertension." Therapeutic Advances in Cardiovascular Disease, vol. 9, no. 4, 2015, pp. 181-90.
Satou R, Shao W, Navar LG. Role of stimulated intrarenal angiotensinogen in hypertension. Ther Adv Cardiovasc Dis. 2015;9(4):181-90.
Satou, R., Shao, W., & Navar, L. G. (2015). Role of stimulated intrarenal angiotensinogen in hypertension. Therapeutic Advances in Cardiovascular Disease, 9(4), 181-90. https://doi.org/10.1177/1753944715585512
Satou R, Shao W, Navar LG. Role of Stimulated Intrarenal Angiotensinogen in Hypertension. Ther Adv Cardiovasc Dis. 2015;9(4):181-90. PubMed PMID: 25987608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of stimulated intrarenal angiotensinogen in hypertension. AU - Satou,Ryousuke, AU - Shao,Weijian, AU - Navar,L Gabriel, Y1 - 2015/05/18/ PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2016/6/9/medline KW - AT1 receptor KW - angiotensin II KW - proximal tubule cells KW - sodium reabsorption SP - 181 EP - 90 JF - Therapeutic advances in cardiovascular disease JO - Ther Adv Cardiovasc Dis VL - 9 IS - 4 N2 - Experimental models of hypertension and patients with inappropriately increased renin formation due to a stenotic kidney, arteriosclerotic narrowing of the renal arterioles or a rare juxtaglomerular cell tumor have shown a progressive augmentation of the intrarenal/intratubular renin-angiotensin system (RAS). The increased intrarenal angiotensin II (Ang II) elicits renal vasoconstriction and enhanced tubular sodium reabsorption in proximal and distal nephron segments. The enhanced intrarenal Ang II levels are due to both increased Ang II type 1 (AT1) receptor mediated Ang II uptake and AT1 receptor dependent stimulation of renal angiotensinogen (AGT) mRNA and augmented AGT production. The increased AGT formation and secretion into the proximal tubular lumen leads to local formation of Ang II, which stimulates proximal transporters such as the sodium/hydrogen exchanger. Enhanced AGT production also leads to spillover of AGT into the distal nephron segments as reflected by AGT in the urine, which provides an index of intrarenal RAS activity. There is also increased Ang II concentration in distal nephron with stimulation of distal sodium transport. Increased urinary excretion of AGT has been demonstrated in patients with hypertension, type 1 and type 2 diabetes mellitus, and several types of chronic kidney diseases indicating an upregulation of intrarenal RAS activity. SN - 1753-9455 UR - https://www.unboundmedicine.com/medline/citation/25987608/Role_of_stimulated_intrarenal_angiotensinogen_in_hypertension_ L2 - http://journals.sagepub.com/doi/full/10.1177/1753944715585512?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -