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ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory.
Sci Rep 2015; 5:10143SR

Abstract

Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and activity-induced long-term potentiation (LTP) of cortico-basolateral amygdala (BLA) synapses are impaired in ASIC1a-null mice, suggesting a critical role of ASICs in fear memory formation. In this study, we found that ASICs were differentially expressed within the amygdala neuronal population, and the extent of LTP at various glutamatergic synapses correlated with the level of ASIC expression in postsynaptic neurons. Importantly, selective deletion of ASIC1a in GABAergic cells, including amygdala output neurons, eliminated LTP in these cells and reduced fear learning to the same extent as that found when ASIC1a was selectively abolished in BLA glutamatergic neurons. Thus, fear learning requires ASIC-dependent LTP at multiple amygdala synapses, including both cortico-BLA input synapses and intra-amygdala synapses on output neurons.

Authors+Show Affiliations

Institute of Neuroscience, National Yang-Ming University, Taipei 112, Taiwan.Molecular Medicine Program, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine and JST, CREST, Maebashi 371-8511, Japan.1] Institute of Neuroscience, National Yang-Ming University, Taipei 112, Taiwan [2] Institute of Brain Science, National Yang-Ming University, Taipei 112, Taiwan [3] Brain Research Center, National Yang-Ming University, Taipei 112, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25988357

Citation

Chiang, Po-Han, et al. "ASIC-dependent LTP at Multiple Glutamatergic Synapses in Amygdala Network Is Required for Fear Memory." Scientific Reports, vol. 5, 2015, p. 10143.
Chiang PH, Chien TC, Chen CC, et al. ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Sci Rep. 2015;5:10143.
Chiang, P. H., Chien, T. C., Chen, C. C., Yanagawa, Y., & Lien, C. C. (2015). ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Scientific Reports, 5, p. 10143. doi:10.1038/srep10143.
Chiang PH, et al. ASIC-dependent LTP at Multiple Glutamatergic Synapses in Amygdala Network Is Required for Fear Memory. Sci Rep. 2015 May 19;5:10143. PubMed PMID: 25988357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. AU - Chiang,Po-Han, AU - Chien,Ta-Chun, AU - Chen,Chih-Cheng, AU - Yanagawa,Yuchio, AU - Lien,Cheng-Chang, Y1 - 2015/05/19/ PY - 2015/01/21/received PY - 2015/03/31/accepted PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2016/3/26/medline SP - 10143 EP - 10143 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and activity-induced long-term potentiation (LTP) of cortico-basolateral amygdala (BLA) synapses are impaired in ASIC1a-null mice, suggesting a critical role of ASICs in fear memory formation. In this study, we found that ASICs were differentially expressed within the amygdala neuronal population, and the extent of LTP at various glutamatergic synapses correlated with the level of ASIC expression in postsynaptic neurons. Importantly, selective deletion of ASIC1a in GABAergic cells, including amygdala output neurons, eliminated LTP in these cells and reduced fear learning to the same extent as that found when ASIC1a was selectively abolished in BLA glutamatergic neurons. Thus, fear learning requires ASIC-dependent LTP at multiple amygdala synapses, including both cortico-BLA input synapses and intra-amygdala synapses on output neurons. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/25988357/ASIC_dependent_LTP_at_multiple_glutamatergic_synapses_in_amygdala_network_is_required_for_fear_memory_ L2 - http://dx.doi.org/10.1038/srep10143 DB - PRIME DP - Unbound Medicine ER -