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Parental oxytocin responses during skin-to-skin contact in pre-term infants.
Early Hum Dev. 2015 Jul; 91(7):401-6.EH

Abstract

OBJECTIVE

Maternal skin-to-skin contact (M-SSC) has been found to reduce adverse consequences of prematurity, however, its neurobiological mechanisms have been unknown. The purpose of the study was to examine oxytocin mechanism in modulating parental stress and anxiety during M-SSC and P-SSC (paternal SSC) with their pre-term infants.

METHODS

Twenty-eight stable pre-term infants and their parents (triads) were recruited in a 2-day cross-over study and 26 mothers and 19 fathers completed the study protocol. Each triad was randomly assigned to one of the two sequences: M-SSC was conducted on day-1 and P-SSC on day-2; and P-SSC on day-1 and M-SSC on day-2. Parents' saliva samples for oxytocin and cortisol assays and visual analog anxiety levels were collected pre-SSC, 30-min during-SSC, and 30-min post-SSC.

RESULTS

Both maternal and paternal oxytocin levels were significantly increased during-SSC from baseline. Maternal oxytocin dropped post-M-SSC, but paternal oxytocin continued to be maintained at a higher level during post-P-SSC. Both maternal and paternal cortisol levels significantly decreased during-SSC from baseline. Maternal cortisol continuously dropped post-M-SSC, but paternal cortisol increased post-P-SSC. Both mothers' and fathers' anxiety levels decreased during-SSC from baseline, and then increased post-SSC. Mother-father dyads also showed correlated or synchronized stress and anxiety responses in the NICU.

CONCLUSION

M-SSC and P-SSC activated the oxytocin release and reduced stress and anxiety responses in mothers and fathers of pre-term infants.

PRACTICE IMPLICATIONS

SSC plays a positive role in early post-partum period and patterns of maternal and paternal bio-behavioral responses to SSC with pre-term infants might be different.

Authors+Show Affiliations

University of Connecticut, School of Nursing, 231 Glenbrook Road U-4026, Storrs, CT 06269-4026, United States. Electronic address: xiaomei.cong@uconn.edu.Bolton School of Nursing, Case Western Reserve University, United States. Electronic address: Susan.Ludington@case.edu.Connecticut Children's Medical Center, University of Connecticut School of Medicine, United States. Electronic address: Hussain@uchc.edu.University of Connecticut, School of Nursing, 231 Glenbrook Road U-4026, Storrs, CT 06269-4026, United States. Electronic address: regina.cusson@uconn.edu.University of Connecticut, School of Nursing, 231 Glenbrook Road U-4026, Storrs, CT 06269-4026, United States. Electronic address: stephen.walsh@uconn.edu.University of Connecticut, School of Nursing, 231 Glenbrook Road U-4026, Storrs, CT 06269-4026, United States. Electronic address: victoria.vazquez@huskymail.uconn.edu.Connecticut Children's Medical Center, University of Connecticut School of Nursing, United States. Electronic address: CBriere@ccmckids.org.University of Connecticut, School of Nursing, 231 Glenbrook Road U-4026, Storrs, CT 06269-4026, United States. Electronic address: dorothy.vittner@uconn.edu.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25988992

Citation

Cong, Xiaomei, et al. "Parental Oxytocin Responses During Skin-to-skin Contact in Pre-term Infants." Early Human Development, vol. 91, no. 7, 2015, pp. 401-6.
Cong X, Ludington-Hoe SM, Hussain N, et al. Parental oxytocin responses during skin-to-skin contact in pre-term infants. Early Hum Dev. 2015;91(7):401-6.
Cong, X., Ludington-Hoe, S. M., Hussain, N., Cusson, R. M., Walsh, S., Vazquez, V., Briere, C. E., & Vittner, D. (2015). Parental oxytocin responses during skin-to-skin contact in pre-term infants. Early Human Development, 91(7), 401-6. https://doi.org/10.1016/j.earlhumdev.2015.04.012
Cong X, et al. Parental Oxytocin Responses During Skin-to-skin Contact in Pre-term Infants. Early Hum Dev. 2015;91(7):401-6. PubMed PMID: 25988992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental oxytocin responses during skin-to-skin contact in pre-term infants. AU - Cong,Xiaomei, AU - Ludington-Hoe,Susan M, AU - Hussain,Naveed, AU - Cusson,Regina M, AU - Walsh,Stephen, AU - Vazquez,Victoria, AU - Briere,Carrie-Ellen, AU - Vittner,Dorothy, Y1 - 2015/05/16/ PY - 2015/02/24/received PY - 2015/04/23/revised PY - 2015/04/25/accepted PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2016/2/26/medline KW - Anxiety KW - Cortisol KW - Maternal skin-to-skin contact KW - Oxytocin KW - Paternal skin-to-skin contact KW - Pre-term infants SP - 401 EP - 6 JF - Early human development JO - Early Hum. Dev. VL - 91 IS - 7 N2 - OBJECTIVE: Maternal skin-to-skin contact (M-SSC) has been found to reduce adverse consequences of prematurity, however, its neurobiological mechanisms have been unknown. The purpose of the study was to examine oxytocin mechanism in modulating parental stress and anxiety during M-SSC and P-SSC (paternal SSC) with their pre-term infants. METHODS: Twenty-eight stable pre-term infants and their parents (triads) were recruited in a 2-day cross-over study and 26 mothers and 19 fathers completed the study protocol. Each triad was randomly assigned to one of the two sequences: M-SSC was conducted on day-1 and P-SSC on day-2; and P-SSC on day-1 and M-SSC on day-2. Parents' saliva samples for oxytocin and cortisol assays and visual analog anxiety levels were collected pre-SSC, 30-min during-SSC, and 30-min post-SSC. RESULTS: Both maternal and paternal oxytocin levels were significantly increased during-SSC from baseline. Maternal oxytocin dropped post-M-SSC, but paternal oxytocin continued to be maintained at a higher level during post-P-SSC. Both maternal and paternal cortisol levels significantly decreased during-SSC from baseline. Maternal cortisol continuously dropped post-M-SSC, but paternal cortisol increased post-P-SSC. Both mothers' and fathers' anxiety levels decreased during-SSC from baseline, and then increased post-SSC. Mother-father dyads also showed correlated or synchronized stress and anxiety responses in the NICU. CONCLUSION: M-SSC and P-SSC activated the oxytocin release and reduced stress and anxiety responses in mothers and fathers of pre-term infants. PRACTICE IMPLICATIONS: SSC plays a positive role in early post-partum period and patterns of maternal and paternal bio-behavioral responses to SSC with pre-term infants might be different. SN - 1872-6232 UR - https://www.unboundmedicine.com/medline/citation/25988992/Parental_oxytocin_responses_during_skin_to_skin_contact_in_pre_term_infants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-3782(15)00089-4 DB - PRIME DP - Unbound Medicine ER -