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Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice.
Pharmacol Biochem Behav. 2015 Aug; 135:31-9.PB

Abstract

To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex. Gabapentin was used as a reference drug in the study. Pregabalin administered i.g. at 12.5 and 25mg/kg prolonged the duration of thermal latencies by 1.4- and 1.6-fold and increased the mechanical threshold by 2.2- and 3.1-fold 3h after administration, respectively, but did not affect motor coordination in PSNL mice, compared with vehicle control. Pregabalin (12.5 and 25mg/kg) given at 6:30 increased the amount of non-rapid eye movement sleep in a 4-h period by 1.3- and 1.4-fold, respectively, in PSNL mice. However, pregabalin (25mg/kg) given at 20:30 did not alter the sleep pattern in normal mice. Immunohistochemical study showed that PSNL increased c-Fos expression in the neurons of anterior cingulate cortex by 2.1-fold, which could be reversed by pregabalin. These results indicate that pregabalin is an effective treatment for both neuropathic pain and sleep disturbance in PSNL mice.

Authors+Show Affiliations

Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China; Department of Pharmacology, Wannan Medical College, Wuhu, China.Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China; Department of Pharmacology, College of Pharmaceutical Science, Fudan University, Shanghai, China.Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.Department of Pharmacology, Wannan Medical College, Wuhu, China.Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China; Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.Baker-Norton Pharmaceutical Co., Ltd, Kunming, China.Department of Pharmacology, Wannan Medical College, Wuhu, China. Electronic address: zyhongwnmc@aliyun.com.Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China; Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. Electronic address: huangzl@fudan.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25989046

Citation

Wang, Tian-Xiao, et al. "Antinociceptive and Hypnotic Activities of Pregabalin in a Neuropathic Pain-like Model in Mice." Pharmacology, Biochemistry, and Behavior, vol. 135, 2015, pp. 31-9.
Wang TX, Yin D, Guo W, et al. Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. Pharmacol Biochem Behav. 2015;135:31-9.
Wang, T. X., Yin, D., Guo, W., Liu, Y. Y., Li, Y. D., Qu, W. M., Han, W. J., Hong, Z. Y., & Huang, Z. L. (2015). Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. Pharmacology, Biochemistry, and Behavior, 135, 31-9. https://doi.org/10.1016/j.pbb.2015.05.007
Wang TX, et al. Antinociceptive and Hypnotic Activities of Pregabalin in a Neuropathic Pain-like Model in Mice. Pharmacol Biochem Behav. 2015;135:31-9. PubMed PMID: 25989046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. AU - Wang,Tian-Xiao, AU - Yin,Dou, AU - Guo,Wei, AU - Liu,Yuan-Yuan, AU - Li,Ya-Dong, AU - Qu,Wei-Min, AU - Han,Wu-Jian, AU - Hong,Zong-Yuan, AU - Huang,Zhi-Li, Y1 - 2015/05/16/ PY - 2015/02/10/received PY - 2015/04/28/revised PY - 2015/05/04/accepted PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2016/4/14/medline KW - Anterior cingulate cortex KW - Neuropathic pain KW - Pregabalin KW - Sleep disturbance KW - c-Fos SP - 31 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 135 N2 - To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex. Gabapentin was used as a reference drug in the study. Pregabalin administered i.g. at 12.5 and 25mg/kg prolonged the duration of thermal latencies by 1.4- and 1.6-fold and increased the mechanical threshold by 2.2- and 3.1-fold 3h after administration, respectively, but did not affect motor coordination in PSNL mice, compared with vehicle control. Pregabalin (12.5 and 25mg/kg) given at 6:30 increased the amount of non-rapid eye movement sleep in a 4-h period by 1.3- and 1.4-fold, respectively, in PSNL mice. However, pregabalin (25mg/kg) given at 20:30 did not alter the sleep pattern in normal mice. Immunohistochemical study showed that PSNL increased c-Fos expression in the neurons of anterior cingulate cortex by 2.1-fold, which could be reversed by pregabalin. These results indicate that pregabalin is an effective treatment for both neuropathic pain and sleep disturbance in PSNL mice. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/25989046/Antinociceptive_and_hypnotic_activities_of_pregabalin_in_a_neuropathic_pain_like_model_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(15)00149-5 DB - PRIME DP - Unbound Medicine ER -