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Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case-control study.
J Transl Med. 2015 May 20; 13:159.JT

Abstract

BACKGROUND

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness. Symptoms include profound fatigue and distinctive post-exertional malaise (PEM). We asked whether a submaximal exercise test would prove useful for identifying different patterns of tissue oxygen utilization in individuals with ME/CFS versus healthy subjects. Such a test has potential to aid with ME/CFS diagnosis, or to characterize patients' illness.

METHODS

A case-control study of 16 patients with ME/CFS compared to 16 healthy controls completing a 3-min handgrip protocol was performed. Response was measured using near-infrared spectroscopy, resulting in measurements of oxygenated (O2Hb) and deoxygenated hemoglobin (HHb) over wrist extensors and flexors. Changes in O2Hb (delta (d)O2Hb) and HHb (dHHb) absorbance between the first and last contraction were calculated, as were the force-time product of all contractions, measured as tension-time index (TTI), and ratings of perceived exertion (RPE).

RESULTS

Individuals with ME/CFS demonstrated smaller dO2Hb and dHHb than controls. However, after adjusting for TTI and change in total hemoglobin (delta (d)tHb), differences in dO2Hb and dHHb were reduced, with large overlapping variances. RPE was significantly higher for cases than controls, particularly at rest.

CONCLUSIONS

Relative to controls, participants with ME/CFS demonstrated higher RPE, lower TTI, and reduced dO2Hb and dHHb during repetitive handgrip exercise, although considerable variance was observed. With further study, submaximal exercise testing may prove useful for stratifying patients with a lower propensity for inducing PEM, and have the ability to establish baseline intensities for exercise prescription.

Authors+Show Affiliations

School of Population and Public Health, British Columbia Centre for Disease Control, University of British Columbia, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada. ruth.miller@bccdc.ca.Department of Physical Therapy, University of Toronto, 160-500 University Avenue, Toronto, ON, M5G 1V7, Canada. darlene.reid@utoronto.ca.Adult Metabolic Disease Clinic, Vancouver General Hospital, Level 4, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada. amattman@providencehealth.bc.ca.Muscle Biophysics Laboratory, Department of Physical Therapy, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, V5Z 3P1, Canada. cristiyama@gmail.com.Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, V5Z 3J5, Canada. flagellin@gmail.com.Centre for Health Evaluation and Outcome Sciences, 588-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada. sparker@cheos.ubc.ca.British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada. jennifer.gardy@bccdc.ca.British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada. Patrick.tang@bccdc.ca.School of Population and Public Health, British Columbia Centre for Disease Control, University of British Columbia, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada. david.patrick@ubc.ca. British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada. david.patrick@ubc.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25990639

Citation

Miller, Ruth R., et al. "Submaximal Exercise Testing With Near-infrared Spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Compared to Healthy Controls: a Case-control Study." Journal of Translational Medicine, vol. 13, 2015, p. 159.
Miller RR, Reid WD, Mattman A, et al. Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case-control study. J Transl Med. 2015;13:159.
Miller, R. R., Reid, W. D., Mattman, A., Yamabayashi, C., Steiner, T., Parker, S., Gardy, J., Tang, P., & Patrick, D. M. (2015). Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case-control study. Journal of Translational Medicine, 13, 159. https://doi.org/10.1186/s12967-015-0527-8
Miller RR, et al. Submaximal Exercise Testing With Near-infrared Spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Compared to Healthy Controls: a Case-control Study. J Transl Med. 2015 May 20;13:159. PubMed PMID: 25990639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case-control study. AU - Miller,Ruth R, AU - Reid,W Darlene, AU - Mattman,Andre, AU - Yamabayashi,Cristiane, AU - Steiner,Theodore, AU - Parker,Shoshana, AU - Gardy,Jennifer, AU - Tang,Patrick, AU - Patrick,David M, Y1 - 2015/05/20/ PY - 2015/03/26/received PY - 2015/05/09/accepted PY - 2015/5/21/entrez PY - 2015/5/21/pubmed PY - 2016/4/14/medline SP - 159 EP - 159 JF - Journal of translational medicine JO - J Transl Med VL - 13 N2 - BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness. Symptoms include profound fatigue and distinctive post-exertional malaise (PEM). We asked whether a submaximal exercise test would prove useful for identifying different patterns of tissue oxygen utilization in individuals with ME/CFS versus healthy subjects. Such a test has potential to aid with ME/CFS diagnosis, or to characterize patients' illness. METHODS: A case-control study of 16 patients with ME/CFS compared to 16 healthy controls completing a 3-min handgrip protocol was performed. Response was measured using near-infrared spectroscopy, resulting in measurements of oxygenated (O2Hb) and deoxygenated hemoglobin (HHb) over wrist extensors and flexors. Changes in O2Hb (delta (d)O2Hb) and HHb (dHHb) absorbance between the first and last contraction were calculated, as were the force-time product of all contractions, measured as tension-time index (TTI), and ratings of perceived exertion (RPE). RESULTS: Individuals with ME/CFS demonstrated smaller dO2Hb and dHHb than controls. However, after adjusting for TTI and change in total hemoglobin (delta (d)tHb), differences in dO2Hb and dHHb were reduced, with large overlapping variances. RPE was significantly higher for cases than controls, particularly at rest. CONCLUSIONS: Relative to controls, participants with ME/CFS demonstrated higher RPE, lower TTI, and reduced dO2Hb and dHHb during repetitive handgrip exercise, although considerable variance was observed. With further study, submaximal exercise testing may prove useful for stratifying patients with a lower propensity for inducing PEM, and have the ability to establish baseline intensities for exercise prescription. SN - 1479-5876 UR - https://www.unboundmedicine.com/medline/citation/25990639/Submaximal_exercise_testing_with_near_infrared_spectroscopy_in_Myalgic_Encephalomyelitis/Chronic_Fatigue_Syndrome_patients_compared_to_healthy_controls:_a_case_control_study_ L2 - https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0527-8 DB - PRIME DP - Unbound Medicine ER -