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Effect of whole body vibration training on bone mineral density and bone quality in adolescents with Down syndrome: a randomized controlled trial.
Osteoporos Int. 2015 Oct; 26(10):2449-59.OI

Abstract

Adolescents with Down syndrome (DS) have poorer bone health than their peers without DS. Twenty-five adolescents with DS were randomly assigned to whole-body vibration training (WBV) or control groups. The results indicate that a 20-week WBV might be useful to improve subtotal bone mineral content and density in adolescents with DS.

INTRODUCTION

This study aims to determine the effects of 20 weeks of whole body vibration training (WBV) on bone mineral content (BMC), density (BMD), and structure variables in adolescents with Down syndrome (DS).

METHODS

This randomized controlled trial of 25 adolescents (12-18 years) with DS (8 females) generated 2 non-equal groups, WBV group (n = 11) and CON group (n = 14). Using an efficacy analysis, the primary outcomes were BMC and BMD by dual-energy X-ray absorptiometry and the secondary were bone structure variables by peripheral quantitative computed tomography. A synchronous vibration platform (PowerPlate®) was used (3/week, 10 repetitions (30-60 s) 1-min rest, frequency of 25-30 Hz, and peak-to-peak displacement of 2 mm (peak acceleration 2.5-3.6 g)).

RESULTS

WBV group improved whole body BMC 2.8%, 95% CI [3.5, 2.1], subtotal area, BMC, and BMD by 2.8, 4.8, and 2%, respectively, 95% confidence intervals (CIs) [3.4, 2.1], [6.5, 3.1], and [2.8, 1.1], respectively (all, p < 0.05), showing group by time interactions in BMC and BMD (both p < 0.05). Lumbar spine BMC and BMD also increased in the WBV group by 6.6 and 3.3% both p < 0.05, 95 % CIs [8.6, 4.7], and [4.9, 1.7], respectively. Regarding bone structure, WBV group showed improvements in tibial BMC at 4 % (2.9 %, 95 % CI [3.0, 2.8]) and in volumetric BMD (vBMD), cortical vBMD, and cortical thickness at 66% of the radius (by 7.0, 2.4, and 10.9%; 95% CIs [7.4, 6.7], [2.6, 2.3], and [12.4, 9.3], respectively) (all, p < 0.05).

CONCLUSIONS

A 20-week WBV, with this protocol, might be useful to improve subtotal BMC and BMD in adolescents with DS.

Authors+Show Affiliations

GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, C/Pedro Cerbuna n° 12, 50009, Zaragoza, Spain. amatute@unizar.es. Faculty of Health and Sport Science (FCSD), Department of Physiatry and Nursing, Universidad de Zaragoza, Ronda Misericordia 5, 22001, Huesca, Spain. amatute@unizar.es.GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, C/Pedro Cerbuna n° 12, 50009, Zaragoza, Spain. alg28@aber.ac.uk. Department of Sport and Exercise Science, Aberystwyth University, Ceredigion, UK. alg28@aber.ac.uk.GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, C/Pedro Cerbuna n° 12, 50009, Zaragoza, Spain. agomez@unizar.es. Centro Universitario de la Defensa, Zaragoza, Spain. agomez@unizar.es.Department of Functional Biology, Universidad de Oviedo, Asturias, Spain. hugo.olmedillas@gmail.com.GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, C/Pedro Cerbuna n° 12, 50009, Zaragoza, Spain. gervicen@unizar.es. Faculty of Health and Sport Science (FCSD), Department of Physiatry and Nursing, Universidad de Zaragoza, Ronda Misericordia 5, 22001, Huesca, Spain. gervicen@unizar.es.GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, C/Pedro Cerbuna n° 12, 50009, Zaragoza, Spain. joseant@unizar.es. Faculty of Health and Sport Science (FCSD), Department of Physiatry and Nursing, Universidad de Zaragoza, Ronda Misericordia 5, 22001, Huesca, Spain. joseant@unizar.es.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25994905

Citation

Matute-Llorente, A, et al. "Effect of Whole Body Vibration Training On Bone Mineral Density and Bone Quality in Adolescents With Down Syndrome: a Randomized Controlled Trial." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 26, no. 10, 2015, pp. 2449-59.
Matute-Llorente A, González-Agüero A, Gómez-Cabello A, et al. Effect of whole body vibration training on bone mineral density and bone quality in adolescents with Down syndrome: a randomized controlled trial. Osteoporos Int. 2015;26(10):2449-59.
Matute-Llorente, A., González-Agüero, A., Gómez-Cabello, A., Olmedillas, H., Vicente-Rodríguez, G., & Casajús, J. A. (2015). Effect of whole body vibration training on bone mineral density and bone quality in adolescents with Down syndrome: a randomized controlled trial. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(10), 2449-59. https://doi.org/10.1007/s00198-015-3159-1
Matute-Llorente A, et al. Effect of Whole Body Vibration Training On Bone Mineral Density and Bone Quality in Adolescents With Down Syndrome: a Randomized Controlled Trial. Osteoporos Int. 2015;26(10):2449-59. PubMed PMID: 25994905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of whole body vibration training on bone mineral density and bone quality in adolescents with Down syndrome: a randomized controlled trial. AU - Matute-Llorente,A, AU - González-Agüero,A, AU - Gómez-Cabello,A, AU - Olmedillas,H, AU - Vicente-Rodríguez,G, AU - Casajús,J A, Y1 - 2015/05/21/ PY - 2014/09/24/received PY - 2015/04/28/accepted PY - 2015/5/22/entrez PY - 2015/5/23/pubmed PY - 2016/7/7/medline KW - Bone health KW - Down’s syndrome KW - Exercise KW - Osteoporosis KW - Vibration SP - 2449 EP - 59 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 26 IS - 10 N2 - UNLABELLED: Adolescents with Down syndrome (DS) have poorer bone health than their peers without DS. Twenty-five adolescents with DS were randomly assigned to whole-body vibration training (WBV) or control groups. The results indicate that a 20-week WBV might be useful to improve subtotal bone mineral content and density in adolescents with DS. INTRODUCTION: This study aims to determine the effects of 20 weeks of whole body vibration training (WBV) on bone mineral content (BMC), density (BMD), and structure variables in adolescents with Down syndrome (DS). METHODS: This randomized controlled trial of 25 adolescents (12-18 years) with DS (8 females) generated 2 non-equal groups, WBV group (n = 11) and CON group (n = 14). Using an efficacy analysis, the primary outcomes were BMC and BMD by dual-energy X-ray absorptiometry and the secondary were bone structure variables by peripheral quantitative computed tomography. A synchronous vibration platform (PowerPlate®) was used (3/week, 10 repetitions (30-60 s) 1-min rest, frequency of 25-30 Hz, and peak-to-peak displacement of 2 mm (peak acceleration 2.5-3.6 g)). RESULTS: WBV group improved whole body BMC 2.8%, 95% CI [3.5, 2.1], subtotal area, BMC, and BMD by 2.8, 4.8, and 2%, respectively, 95% confidence intervals (CIs) [3.4, 2.1], [6.5, 3.1], and [2.8, 1.1], respectively (all, p < 0.05), showing group by time interactions in BMC and BMD (both p < 0.05). Lumbar spine BMC and BMD also increased in the WBV group by 6.6 and 3.3% both p < 0.05, 95 % CIs [8.6, 4.7], and [4.9, 1.7], respectively. Regarding bone structure, WBV group showed improvements in tibial BMC at 4 % (2.9 %, 95 % CI [3.0, 2.8]) and in volumetric BMD (vBMD), cortical vBMD, and cortical thickness at 66% of the radius (by 7.0, 2.4, and 10.9%; 95% CIs [7.4, 6.7], [2.6, 2.3], and [12.4, 9.3], respectively) (all, p < 0.05). CONCLUSIONS: A 20-week WBV, with this protocol, might be useful to improve subtotal BMC and BMD in adolescents with DS. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/25994905/Effect_of_whole_body_vibration_training_on_bone_mineral_density_and_bone_quality_in_adolescents_with_Down_syndrome:_a_randomized_controlled_trial_ L2 - https://doi.org/10.1007/s00198-015-3159-1 DB - PRIME DP - Unbound Medicine ER -