Tags

Type your tag names separated by a space and hit enter

Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials.
J Nutr. 2015 Jul; 145(7):1549-58.JN

Abstract

BACKGROUND

Palm oil contains a high amount of saturated fat compared with most other vegetable oils, but studies have reported inconsistent effects of palm oil on blood lipids.

OBJECTIVE

We systematically reviewed the effect of palm oil consumption on blood lipids compared with other cooking oils using data from clinical trials.

METHODS

We searched PubMed and the Cochrane Library for trials of at least 2 wk duration that compared the effects of palm oil consumption with any of the predefined comparison oils: vegetable oils low in saturated fat, trans fat-containing partially hydrogenated vegetable oils, and animal fats. Data were pooled by using random-effects meta-analysis.

RESULTS

Palm oil significantly increased LDL cholesterol by 0.24 mmol/L (95% CI: 0.13, 0.35 mmol/L; I(2) = 83.2%) compared with vegetable oils low in saturated fat. This effect was observed in randomized trials (0.31 mmol/L; 95% CI: 0.20, 0.42 mmol/L) but not in nonrandomized trials (0.03 mmol/L; 95% CI: -0.15, 0.20 mmol/L; P-difference = 0.02). Among randomized trials, only modest heterogeneity in study results remained after considering the test oil dose and the comparison oil type (I(2) = 27.5%). Palm oil increased HDL cholesterol by 0.02 mmol/L (95% CI: 0.01, 0.04 mmol/L; I(2) = 49.8%) compared with vegetable oils low in saturated fat and by 0.09 mmol/L (95% CI: 0.06, 0.11 mmol/L; I(2) = 47.8%) compared with trans fat-containing oils.

CONCLUSIONS

Palm oil consumption results in higher LDL cholesterol than do vegetable oils low in saturated fat and higher HDL cholesterol than do trans fat-containing oils in humans. The effects of palm oil on blood lipids are as expected on the basis of its high saturated fat content, which supports the reduction in palm oil use by replacement with vegetable oils low in saturated and trans fat. This systematic review was registered with the PROSPERO registry at http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42012002601#.VU3wvSGeDRZ as CRD42012002601.

Authors+Show Affiliations

Saw Swee Hock School of Public Health and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.Saw Swee Hock School of Public Health and.Saw Swee Hock School of Public Health and.Saw Swee Hock School of Public Health and.Saw Swee Hock School of Public Health and.Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Department of Nutrition, Harvard School of Public Health, Boston, MA; and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore rob_martinus_van_dam@nuhs.edu.sg.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25995283

Citation

Sun, Ye, et al. "Palm Oil Consumption Increases LDL Cholesterol Compared With Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials." The Journal of Nutrition, vol. 145, no. 7, 2015, pp. 1549-58.
Sun Y, Neelakantan N, Wu Y, et al. Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials. J Nutr. 2015;145(7):1549-58.
Sun, Y., Neelakantan, N., Wu, Y., Lote-Oke, R., Pan, A., & van Dam, R. M. (2015). Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials. The Journal of Nutrition, 145(7), 1549-58. https://doi.org/10.3945/jn.115.210575
Sun Y, et al. Palm Oil Consumption Increases LDL Cholesterol Compared With Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials. J Nutr. 2015;145(7):1549-58. PubMed PMID: 25995283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials. AU - Sun,Ye, AU - Neelakantan,Nithya, AU - Wu,Yi, AU - Lote-Oke,Rashmi, AU - Pan,An, AU - van Dam,Rob M, Y1 - 2015/05/20/ PY - 2015/01/15/received PY - 2015/04/28/accepted PY - 2015/5/22/entrez PY - 2015/5/23/pubmed PY - 2015/9/15/medline KW - HDL KW - LDL KW - cholesterol KW - diet KW - lipids KW - meta-analysis KW - nutrition KW - triglycerides SP - 1549 EP - 58 JF - The Journal of nutrition JO - J Nutr VL - 145 IS - 7 N2 - BACKGROUND: Palm oil contains a high amount of saturated fat compared with most other vegetable oils, but studies have reported inconsistent effects of palm oil on blood lipids. OBJECTIVE: We systematically reviewed the effect of palm oil consumption on blood lipids compared with other cooking oils using data from clinical trials. METHODS: We searched PubMed and the Cochrane Library for trials of at least 2 wk duration that compared the effects of palm oil consumption with any of the predefined comparison oils: vegetable oils low in saturated fat, trans fat-containing partially hydrogenated vegetable oils, and animal fats. Data were pooled by using random-effects meta-analysis. RESULTS: Palm oil significantly increased LDL cholesterol by 0.24 mmol/L (95% CI: 0.13, 0.35 mmol/L; I(2) = 83.2%) compared with vegetable oils low in saturated fat. This effect was observed in randomized trials (0.31 mmol/L; 95% CI: 0.20, 0.42 mmol/L) but not in nonrandomized trials (0.03 mmol/L; 95% CI: -0.15, 0.20 mmol/L; P-difference = 0.02). Among randomized trials, only modest heterogeneity in study results remained after considering the test oil dose and the comparison oil type (I(2) = 27.5%). Palm oil increased HDL cholesterol by 0.02 mmol/L (95% CI: 0.01, 0.04 mmol/L; I(2) = 49.8%) compared with vegetable oils low in saturated fat and by 0.09 mmol/L (95% CI: 0.06, 0.11 mmol/L; I(2) = 47.8%) compared with trans fat-containing oils. CONCLUSIONS: Palm oil consumption results in higher LDL cholesterol than do vegetable oils low in saturated fat and higher HDL cholesterol than do trans fat-containing oils in humans. The effects of palm oil on blood lipids are as expected on the basis of its high saturated fat content, which supports the reduction in palm oil use by replacement with vegetable oils low in saturated and trans fat. This systematic review was registered with the PROSPERO registry at http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42012002601#.VU3wvSGeDRZ as CRD42012002601. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/25995283/Palm_Oil_Consumption_Increases_LDL_Cholesterol_Compared_with_Vegetable_Oils_Low_in_Saturated_Fat_in_a_Meta_Analysis_of_Clinical_Trials_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.115.210575 DB - PRIME DP - Unbound Medicine ER -