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Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study.

Abstract

OBJECTIVE

Despite a prevailing assumption that adult ADHD is a childhood-onset neurodevelopmental disorder, no prospective longitudinal study has described the childhoods of the adult ADHD population. The authors report follow-back analyses of ADHD cases diagnosed in adulthood, alongside follow-forward analyses of ADHD cases diagnosed in childhood, in one cohort.

METHOD

Participants belonged to a representative birth cohort of 1,037 individuals born in Dunedin, New Zealand, in 1972 and 1973 and followed to age 38, with 95% retention. Symptoms of ADHD, associated clinical features, comorbid disorders, neuropsychological deficits, genome-wide association study-derived polygenic risk, and life impairment indicators were assessed. Data sources were participants, parents, teachers, informants, neuropsychological test results, and administrative records. Adult ADHD diagnoses used DSM-5 criteria, apart from onset age and cross-setting corroboration, which were study outcome measures.

RESULTS

As expected, childhood ADHD had a prevalence of 6% (predominantly male) and was associated with childhood comorbid disorders, neurocognitive deficits, polygenic risk, and residual adult life impairment. Also as expected, adult ADHD had a prevalence of 3% (gender balanced) and was associated with adult substance dependence, adult life impairment, and treatment contact. Unexpectedly, the childhood ADHD and adult ADHD groups comprised virtually nonoverlapping sets; 90% of adult ADHD cases lacked a history of childhood ADHD. Also unexpectedly, the adult ADHD group did not show tested neuropsychological deficits in childhood or adulthood, nor did they show polygenic risk for childhood ADHD.

CONCLUSIONS

The findings raise the possibility that adults presenting with the ADHD symptom picture may not have a childhood-onset neurodevelopmental disorder. If this finding is replicated, then the disorder's place in the classification system must be reconsidered, and research must investigate the etiology of adult ADHD.

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    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    ,

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    From the Department of Psychology and Neuroscience, the Department of Psychiatry and Behavioral Sciences, School of Medicine, the Center for Genomic and Computational Biology, and the Social Science Research Institute, Duke University, Durham, N.C.; the Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London; the Department of Psychology, University of Otago, Dunedin, New Zealand; the Department of Psychology, Arizona State University, Tempe; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; and the Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Allegre, Brazil.

    Source

    The American journal of psychiatry 172:10 2015 Oct pg 967-77

    MeSH

    Adolescent
    Adult
    Attention Deficit Disorder with Hyperactivity
    Child
    Female
    Humans
    Longitudinal Studies
    Male
    Neurodevelopmental Disorders
    Neuropsychological Tests
    New Zealand
    Prevalence
    Prospective Studies

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25998281

    Citation

    Moffitt, Terrie E., et al. "Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study." The American Journal of Psychiatry, vol. 172, no. 10, 2015, pp. 967-77.
    Moffitt TE, Houts R, Asherson P, et al. Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study. Am J Psychiatry. 2015;172(10):967-77.
    Moffitt, T. E., Houts, R., Asherson, P., Belsky, D. W., Corcoran, D. L., Hammerle, M., ... Caspi, A. (2015). Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study. The American Journal of Psychiatry, 172(10), pp. 967-77. doi:10.1176/appi.ajp.2015.14101266.
    Moffitt TE, et al. Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study. Am J Psychiatry. 2015;172(10):967-77. PubMed PMID: 25998281.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study. AU - Moffitt,Terrie E, AU - Houts,Renate, AU - Asherson,Philip, AU - Belsky,Daniel W, AU - Corcoran,David L, AU - Hammerle,Maggie, AU - Harrington,HonaLee, AU - Hogan,Sean, AU - Meier,Madeline H, AU - Polanczyk,Guilherme V, AU - Poulton,Richie, AU - Ramrakha,Sandhya, AU - Sugden,Karen, AU - Williams,Benjamin, AU - Rohde,Luis Augusto, AU - Caspi,Avshalom, Y1 - 2015/05/22/ PY - 2015/5/23/entrez PY - 2015/5/23/pubmed PY - 2016/1/2/medline SP - 967 EP - 77 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 172 IS - 10 N2 - OBJECTIVE: Despite a prevailing assumption that adult ADHD is a childhood-onset neurodevelopmental disorder, no prospective longitudinal study has described the childhoods of the adult ADHD population. The authors report follow-back analyses of ADHD cases diagnosed in adulthood, alongside follow-forward analyses of ADHD cases diagnosed in childhood, in one cohort. METHOD: Participants belonged to a representative birth cohort of 1,037 individuals born in Dunedin, New Zealand, in 1972 and 1973 and followed to age 38, with 95% retention. Symptoms of ADHD, associated clinical features, comorbid disorders, neuropsychological deficits, genome-wide association study-derived polygenic risk, and life impairment indicators were assessed. Data sources were participants, parents, teachers, informants, neuropsychological test results, and administrative records. Adult ADHD diagnoses used DSM-5 criteria, apart from onset age and cross-setting corroboration, which were study outcome measures. RESULTS: As expected, childhood ADHD had a prevalence of 6% (predominantly male) and was associated with childhood comorbid disorders, neurocognitive deficits, polygenic risk, and residual adult life impairment. Also as expected, adult ADHD had a prevalence of 3% (gender balanced) and was associated with adult substance dependence, adult life impairment, and treatment contact. Unexpectedly, the childhood ADHD and adult ADHD groups comprised virtually nonoverlapping sets; 90% of adult ADHD cases lacked a history of childhood ADHD. Also unexpectedly, the adult ADHD group did not show tested neuropsychological deficits in childhood or adulthood, nor did they show polygenic risk for childhood ADHD. CONCLUSIONS: The findings raise the possibility that adults presenting with the ADHD symptom picture may not have a childhood-onset neurodevelopmental disorder. If this finding is replicated, then the disorder's place in the classification system must be reconsidered, and research must investigate the etiology of adult ADHD. SN - 1535-7228 UR - https://www.unboundmedicine.com/medline/citation/25998281/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2015.14101266?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -