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Nervous system Lyme disease.
Infect Dis Clin North Am. 2015 Jun; 29(2):241-53.ID

Abstract

Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-Bburgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease.

Authors+Show Affiliations

Department of Neurosciences, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA; Department of Neurology and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: john.halperin@atlantichealth.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25999221

Citation

Halperin, John J.. "Nervous System Lyme Disease." Infectious Disease Clinics of North America, vol. 29, no. 2, 2015, pp. 241-53.
Halperin JJ. Nervous system Lyme disease. Infect Dis Clin North Am. 2015;29(2):241-53.
Halperin, J. J. (2015). Nervous system Lyme disease. Infectious Disease Clinics of North America, 29(2), 241-53. https://doi.org/10.1016/j.idc.2015.02.002
Halperin JJ. Nervous System Lyme Disease. Infect Dis Clin North Am. 2015;29(2):241-53. PubMed PMID: 25999221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nervous system Lyme disease. A1 - Halperin,John J, PY - 2015/5/23/entrez PY - 2015/5/23/pubmed PY - 2016/2/9/medline KW - Borrelia burgdorferi KW - Central nervous system KW - Garin-Bujadoux Bannwarth syndrome KW - Intrathecal antibody KW - Lyme disease KW - Nervous system KW - Neuroborreliosis KW - Peripheral nervous system SP - 241 EP - 53 JF - Infectious disease clinics of North America JO - Infect. Dis. Clin. North Am. VL - 29 IS - 2 N2 - Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-Bburgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease. SN - 1557-9824 UR - https://www.unboundmedicine.com/medline/citation/25999221/Nervous_system_Lyme_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5520(15)00016-1 DB - PRIME DP - Unbound Medicine ER -