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Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder.

Abstract

Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetes mellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine and Biomedicine, University of Palermo, 90100 Palermo, Italy.

    ,

    Department of Internal Medicine and Biomedicine, University of Palermo, 90100 Palermo, Italy.

    ,

    Department of Internal Medicine and Biomedicine, University of Palermo, 90100 Palermo, Italy.

    ,

    Department of Human Pathology, University of Messina, 98125 Messina, Italy ; IFC CNR, Messina Unit, 98100 Messina, Italy.

    ,

    Infectious Diseases Unit, Papardo-Piemonte Hospital, 98125 Messina, Italy.

    Department of Human Pathology, University of Messina, 98125 Messina, Italy ; AILMI-ONLUS Italian Association for the Control of Infectious Diseases, University of Messina, 98125 Messina, Italy.

    Source

    BioMed research international 2015: 2015 pg 735615

    MeSH

    Antiretroviral Therapy, Highly Active
    Bone Diseases
    HIV Infections
    Humans
    Prevalence
    Risk Factors
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26000302

    Citation

    Mansueto, Pasquale, et al. "Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder." BioMed Research International, vol. 2015, 2015, p. 735615.
    Mansueto P, Seidita A, Vitale G, et al. Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder. Biomed Res Int. 2015;2015:735615.
    Mansueto, P., Seidita, A., Vitale, G., Gangemi, S., Iaria, C., & Cascio, A. (2015). Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder. BioMed Research International, 2015, p. 735615. doi:10.1155/2015/735615.
    Mansueto P, et al. Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder. Biomed Res Int. 2015;2015:735615. PubMed PMID: 26000302.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder. AU - Mansueto,Pasquale, AU - Seidita,Aurelio, AU - Vitale,Giustina, AU - Gangemi,Sebastiano, AU - Iaria,Chiara, AU - Cascio,Antonio, Y1 - 2015/04/27/ PY - 2014/11/19/received PY - 2015/02/18/revised PY - 2015/03/02/accepted PY - 2015/5/23/entrez PY - 2015/5/23/pubmed PY - 2016/2/16/medline SP - 735615 EP - 735615 JF - BioMed research international JO - Biomed Res Int VL - 2015 N2 - Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetes mellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/26000302/full_citation L2 - https://dx.doi.org/10.1155/2015/735615 DB - PRIME DP - Unbound Medicine ER -