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Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture.
Osteoporos Int. 2015 Oct; 26(10):2461-9.OI

Abstract

Distal radius (wrist) fracture (DRF) in women over age 50 years is an early sign of bone fragility. Women with a recent DRF compared to women without DRF demonstrated lower bone strength, muscle density, and strength, but no difference in dual-energy x-ray absorptiometry (DXA) measures, suggesting DXA alone may not be a sufficient predictor for DRF risk.

INTRODUCTION

The objective of this study was to investigate differences in bone and muscle properties between women with and without a recent DRF.

METHODS

One hundred sixty-six postmenopausal women (50-78 years) were recruited. Participants were excluded if they had taken bone-altering medications in the past 6 months or had medical conditions that severely affected daily living or the upper extremity. Seventy-seven age-matched women with a fracture in the past 6-24 months (Fx, n = 32) and without fracture (NFx, n = 45) were measured for bone and muscle properties using the nondominant (NFx) or non-fractured limb (Fx). Peripheral quantitative computed tomography (pQCT) was used to estimate bone strength in compression (BSIc) at the distal radius and tibia, bone strength in torsion (SSIp) at the shaft sites, muscle density, and area at the forearm and lower leg. Areal bone mineral density at the ultradistal forearm, spine, and femoral neck was measured by DXA. Grip strength and the 30-s chair stand test were used as estimates of upper and lower extremity muscle strength. Limb-specific between-group differences were compared using multivariate analysis of variance (MANOVA).

RESULTS

There was a significant group difference (p < 0.05) for the forearm and lower leg, with the Fx group demonstrating 16 and 19% lower BSIc, 3 and 6% lower muscle density, and 20 and 21% lower muscle strength at the upper and lower extremities, respectively. There were no differences between groups for DXA measures.

CONCLUSIONS

Women with recent DRF had lower pQCT-derived estimated bone strength at the distal radius and tibia and lower muscle density and strength at both extremities.

Authors+Show Affiliations

School of Physical Therapy, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. katie.crockett@usask.ca.School of Physical Therapy, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.School of Physical Therapy, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada. saija.kontulainen@usask.ca.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26001559

Citation

Crockett, K, et al. "Bone Strength and Muscle Properties in Postmenopausal Women With and Without a Recent Distal Radius Fracture." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 26, no. 10, 2015, pp. 2461-9.
Crockett K, Arnold CM, Farthing JP, et al. Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture. Osteoporos Int. 2015;26(10):2461-9.
Crockett, K., Arnold, C. M., Farthing, J. P., Chilibeck, P. D., Johnston, J. D., Bath, B., Baxter-Jones, A. D., & Kontulainen, S. A. (2015). Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(10), 2461-9. https://doi.org/10.1007/s00198-015-3160-8
Crockett K, et al. Bone Strength and Muscle Properties in Postmenopausal Women With and Without a Recent Distal Radius Fracture. Osteoporos Int. 2015;26(10):2461-9. PubMed PMID: 26001559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture. AU - Crockett,K, AU - Arnold,C M, AU - Farthing,J P, AU - Chilibeck,P D, AU - Johnston,J D, AU - Bath,B, AU - Baxter-Jones,A D G, AU - Kontulainen,S A, Y1 - 2015/05/23/ PY - 2015/01/22/received PY - 2015/04/29/accepted PY - 2015/5/24/entrez PY - 2015/5/24/pubmed PY - 2016/7/7/medline KW - Distal radius fracture KW - Dual-energy x-ray absorptiometry (DXA) KW - Musculoskeletal properties KW - Peripheral quantitative computed tomography (pQCT) SP - 2461 EP - 9 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 26 IS - 10 N2 - UNLABELLED: Distal radius (wrist) fracture (DRF) in women over age 50 years is an early sign of bone fragility. Women with a recent DRF compared to women without DRF demonstrated lower bone strength, muscle density, and strength, but no difference in dual-energy x-ray absorptiometry (DXA) measures, suggesting DXA alone may not be a sufficient predictor for DRF risk. INTRODUCTION: The objective of this study was to investigate differences in bone and muscle properties between women with and without a recent DRF. METHODS: One hundred sixty-six postmenopausal women (50-78 years) were recruited. Participants were excluded if they had taken bone-altering medications in the past 6 months or had medical conditions that severely affected daily living or the upper extremity. Seventy-seven age-matched women with a fracture in the past 6-24 months (Fx, n = 32) and without fracture (NFx, n = 45) were measured for bone and muscle properties using the nondominant (NFx) or non-fractured limb (Fx). Peripheral quantitative computed tomography (pQCT) was used to estimate bone strength in compression (BSIc) at the distal radius and tibia, bone strength in torsion (SSIp) at the shaft sites, muscle density, and area at the forearm and lower leg. Areal bone mineral density at the ultradistal forearm, spine, and femoral neck was measured by DXA. Grip strength and the 30-s chair stand test were used as estimates of upper and lower extremity muscle strength. Limb-specific between-group differences were compared using multivariate analysis of variance (MANOVA). RESULTS: There was a significant group difference (p < 0.05) for the forearm and lower leg, with the Fx group demonstrating 16 and 19% lower BSIc, 3 and 6% lower muscle density, and 20 and 21% lower muscle strength at the upper and lower extremities, respectively. There were no differences between groups for DXA measures. CONCLUSIONS: Women with recent DRF had lower pQCT-derived estimated bone strength at the distal radius and tibia and lower muscle density and strength at both extremities. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/26001559/Bone_strength_and_muscle_properties_in_postmenopausal_women_with_and_without_a_recent_distal_radius_fracture_ L2 - https://doi.org/10.1007/s00198-015-3160-8 DB - PRIME DP - Unbound Medicine ER -