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Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test.
Regul Toxicol Pharmacol. 2015 Aug; 72(3):506-13.RT

Abstract

In the neotropical savannah, Astronium species are used in popular medicine to treat allergies, inflammation, diarrhea and ulcers. Given that natural products are promising starting points for the discovery of novel potentially therapeutic agents, the aim of the present study was to investigate the mutagenic and antimutagenic activities of hydroalcoholic extracts of Astronium spp. The mutagenicity was determined by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102. The antimutagenicity was tested against the direct-acting and indirect-acting mutagens. The results showed that none of the extracts induce any increase in the number of revertants, demonstrating the absence of mutagenic activity. On the other hand, the results on the antimutagenic potential showed a moderate inhibitory effect against NPD and a strong protective effect against B[a]P and AFB1. This study highlights the importance of screening species of Astronium for new medicinal compounds. The promising results obtained open up new avenues for further study and provide a better understanding the mechanisms by which these species act in protecting DNA from damage. However, further pharmacological and toxicological investigations of crude extracts of Astronium spp., as well as of its secondary metabolites, are necessary to determine the mechanism(s) of action to guarantee their safer and more effective application to human health.

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Authors+Show Affiliations

Resende FA
Department of Biological Sciences and Health, Centro Universitário de Araraquara, UNIARA, CEP 14801-340 Araraquara, São Paulo, Brazil; Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil. Electronic address: flaviabiomed@yahoo.com.br.
Campos DL
Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil.
da Silva VC
Department of Organic Chemistry, Chemistry Institute of Araraquara, UNESP-São Paulo State University, CEP 14801-970 Araraquara, São Paulo, Brazil.
De Grandis RA
Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil.
Souza LP
Department of Organic Chemistry, Chemistry Institute of Araraquara, UNESP-São Paulo State University, CEP 14801-970 Araraquara, São Paulo, Brazil.
Leonardo Junior CS
Department of Organic Chemistry, Chemistry Institute of Araraquara, UNESP-São Paulo State University, CEP 14801-970 Araraquara, São Paulo, Brazil.
da Rocha CQ
UNESP-São Paulo State University, Experimental Campus of the Paulista Coast, CEP 11330-900 São Vicente, São Paulo, Brazil.
dos Santos LC
Department of Organic Chemistry, Chemistry Institute of Araraquara, UNESP-São Paulo State University, CEP 14801-970 Araraquara, São Paulo, Brazil.
Vilegas W
UNESP-São Paulo State University, Experimental Campus of the Paulista Coast, CEP 11330-900 São Vicente, São Paulo, Brazil.
Varanda EA
Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil.

MeSH

AnacardiaceaeAntimutagenic AgentsMutagenicity TestsMutagensPlant ExtractsSalmonella typhimurium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26002624

Citation

Resende, Flávia Aparecida, et al. "Mutagenicity and Chemopreventive Activities of Astronium Species Assessed By Ames Test." Regulatory Toxicology and Pharmacology : RTP, vol. 72, no. 3, 2015, pp. 506-13.
Resende FA, Campos DL, da Silva VC, et al. Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test. Regul Toxicol Pharmacol. 2015;72(3):506-13.
Resende, F. A., Campos, D. L., da Silva, V. C., De Grandis, R. A., Souza, L. P., Leonardo Junior, C. S., da Rocha, C. Q., dos Santos, L. C., Vilegas, W., & Varanda, E. A. (2015). Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test. Regulatory Toxicology and Pharmacology : RTP, 72(3), 506-13. https://doi.org/10.1016/j.yrtph.2015.05.014
Resende FA, et al. Mutagenicity and Chemopreventive Activities of Astronium Species Assessed By Ames Test. Regul Toxicol Pharmacol. 2015;72(3):506-13. PubMed PMID: 26002624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test. AU - Resende,Flávia Aparecida, AU - Campos,Debora Leite, AU - da Silva,Viviane Cândida, AU - De Grandis,Rone Aparecido, AU - Souza,Leonardo Perez, AU - Leonardo Junior,Carlos Sérgio, AU - da Rocha,Cláudia Quintino, AU - dos Santos,Lourdes Campaner, AU - Vilegas,Wagner, AU - Varanda,Eliana Aparecida, Y1 - 2015/05/19/ PY - 2015/01/26/received PY - 2015/05/12/revised PY - 2015/05/13/accepted PY - 2015/5/24/entrez PY - 2015/5/24/pubmed PY - 2016/5/25/medline KW - Ames test KW - Antimutagenicity KW - Astronium spp. KW - Mutagenicity SP - 506 EP - 13 JF - Regulatory toxicology and pharmacology : RTP JO - Regul Toxicol Pharmacol VL - 72 IS - 3 N2 - In the neotropical savannah, Astronium species are used in popular medicine to treat allergies, inflammation, diarrhea and ulcers. Given that natural products are promising starting points for the discovery of novel potentially therapeutic agents, the aim of the present study was to investigate the mutagenic and antimutagenic activities of hydroalcoholic extracts of Astronium spp. The mutagenicity was determined by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102. The antimutagenicity was tested against the direct-acting and indirect-acting mutagens. The results showed that none of the extracts induce any increase in the number of revertants, demonstrating the absence of mutagenic activity. On the other hand, the results on the antimutagenic potential showed a moderate inhibitory effect against NPD and a strong protective effect against B[a]P and AFB1. This study highlights the importance of screening species of Astronium for new medicinal compounds. The promising results obtained open up new avenues for further study and provide a better understanding the mechanisms by which these species act in protecting DNA from damage. However, further pharmacological and toxicological investigations of crude extracts of Astronium spp., as well as of its secondary metabolites, are necessary to determine the mechanism(s) of action to guarantee their safer and more effective application to human health. SN - 1096-0295 UR - https://www.unboundmedicine.com/medline/citation/26002624/Mutagenicity_and_chemopreventive_activities_of_Astronium_species_assessed_by_Ames_test_ DB - PRIME DP - Unbound Medicine ER -