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Formulation of bi-layer matrix tablets of tramadol hydrochloride: Comparison of rate retarding ability of the incorporated hydrophilic polymers.
Pak J Pharm Sci. 2015 May; 28(3):855-61.PJ

Abstract

Bi-layer tablets of tramadol hydrochloride were prepared by direct compression technique. Each tablet contains an instant release layer with a sustained release layer. The instant release layer was found to release the initial dose immediately within minutes. The instant release layer was combined with sustained release matrix made of varying quantity of Methocel K4M, Methocel K15MCR and Carbomer 974P. Bi-layer tablets were evaluated for various physical tests including weight variation, thickness and diameter, hardness and percent friability. Drug release from bi-layer tablet was studied in acidic medium and buffer medium for two and six hours respectively. Sustained release of tramadol hydrochloride was observed with a controlled fashion that was characteristic to the type and extent of polymer used. % Drug release from eight-hour dissolution study was fitted with several kinetic models. Mean dissolution time (MDT) and fractional dissolution values (T25%, T50% and T80%) were also calculated as well, to compare the retarding ability of the polymers. Methocel K15MCR was found to be the most effective in rate retardation of freely water-soluble tramadol hydrochloride compared to Methocel K4M and Capbomer 974P, when incorporated at equal ratio in the formulation.

Authors+Show Affiliations

Arif H
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh.
Al-Masum A
Research & Development Formulation Department, Incepta Pharmaceuticals Ltd., Savar, Dhaka, Bangladesh.
Sharmin F
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh.
Reza S
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Sm Islam SA
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh.

MeSH

Acrylic ResinsAnalgesics, OpioidDelayed-Action PreparationsDrug CompoundingHardnessMethylcelluloseTabletsTramadol

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26004717

Citation

Arif, Hasanul, et al. "Formulation of Bi-layer Matrix Tablets of Tramadol Hydrochloride: Comparison of Rate Retarding Ability of the Incorporated Hydrophilic Polymers." Pakistan Journal of Pharmaceutical Sciences, vol. 28, no. 3, 2015, pp. 855-61.
Arif H, Al-Masum A, Sharmin F, et al. Formulation of bi-layer matrix tablets of tramadol hydrochloride: Comparison of rate retarding ability of the incorporated hydrophilic polymers. Pak J Pharm Sci. 2015;28(3):855-61.
Arif, H., Al-Masum, A., Sharmin, F., Reza, S., & Sm Islam, S. A. (2015). Formulation of bi-layer matrix tablets of tramadol hydrochloride: Comparison of rate retarding ability of the incorporated hydrophilic polymers. Pakistan Journal of Pharmaceutical Sciences, 28(3), 855-61.
Arif H, et al. Formulation of Bi-layer Matrix Tablets of Tramadol Hydrochloride: Comparison of Rate Retarding Ability of the Incorporated Hydrophilic Polymers. Pak J Pharm Sci. 2015;28(3):855-61. PubMed PMID: 26004717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation of bi-layer matrix tablets of tramadol hydrochloride: Comparison of rate retarding ability of the incorporated hydrophilic polymers. AU - Arif,Hasanul, AU - Al-Masum,Abdullah, AU - Sharmin,Florida, AU - Reza,Selim, AU - Sm Islam,Sm Ashraful, PY - 2015/5/26/entrez PY - 2015/5/26/pubmed PY - 2015/8/11/medline SP - 855 EP - 61 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 28 IS - 3 N2 - Bi-layer tablets of tramadol hydrochloride were prepared by direct compression technique. Each tablet contains an instant release layer with a sustained release layer. The instant release layer was found to release the initial dose immediately within minutes. The instant release layer was combined with sustained release matrix made of varying quantity of Methocel K4M, Methocel K15MCR and Carbomer 974P. Bi-layer tablets were evaluated for various physical tests including weight variation, thickness and diameter, hardness and percent friability. Drug release from bi-layer tablet was studied in acidic medium and buffer medium for two and six hours respectively. Sustained release of tramadol hydrochloride was observed with a controlled fashion that was characteristic to the type and extent of polymer used. % Drug release from eight-hour dissolution study was fitted with several kinetic models. Mean dissolution time (MDT) and fractional dissolution values (T25%, T50% and T80%) were also calculated as well, to compare the retarding ability of the polymers. Methocel K15MCR was found to be the most effective in rate retardation of freely water-soluble tramadol hydrochloride compared to Methocel K4M and Capbomer 974P, when incorporated at equal ratio in the formulation. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/26004717/Formulation_of_bi_layer_matrix_tablets_of_tramadol_hydrochloride:_Comparison_of_rate_retarding_ability_of_the_incorporated_hydrophilic_polymers_ DB - PRIME DP - Unbound Medicine ER -